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Mk866

Manufactured by Cayman Chemical
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Sourced in United States

MK866 is a small molecule inhibitor of the enzyme 5-lipoxygenase activating protein (FLAP). It is a research tool used in the study of the arachidonic acid metabolic pathway and the role of leukotrienes in various biological processes.

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Lab products found in correlation

Sb203580, by Cayman Chemical (1 mentions) Birb796, by Cayman Chemical (1 mentions) Tween 80, by Kanto Chemical (1 mentions) Dimethyl sulfoxide (dmso), by Fujifilm (1 mentions) Phosphate buffered saline (pbs), by Thermo Fisher Scientific (1 mentions)

3 protocols using mk866

1

Inhibitor Screening in Cellular Assays

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Inhibitors were used where specified at the designated concentrations, including MK-866 (Cayman Chemicals catalog # 21753), BIRB-796 (Cayman Chemicals catalog # 10460), NVP-BKM120 (Cayman Chemicals catalog # 11587), and SB203580 (Cayman Chemicals catalog # 13067).
, & Weir E. (2000). Anthrax: of bison and bioterrorism. CMAJ: Canadian Medical Association Journal, 163(5), 608.
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2

OEA and PPAR-α Antagonist Study

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OEA and MK866, a PPAR-α antagonist, were purchased from Cayman Chemical (Ann Arbor, MI, USA). OEA was dissolved in dimethyl sulfoxide (DMSO, Wako Pure Chemical Industries, Osaka, Japan) for the in vitro experiments and was dissolved in a vehicle composed of Tween 80 (Kanto Chemical, Tokyo, Japan), DMSO, and phosphate-buffered saline (PBS, Life Technologies, Carlsbad, CA, USA) (1:0.5:18.5 by volume) for the in vivo experiments.
Otagiri S., Ohnishi S., Ohara M., Fu Q., Yamamoto K., Yamamoto K., Katsurada T, & Sakamoto N. (2020). Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats. Frontiers in Pharmacology, 11, 1277.
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3

Synthesis and Characterization of OEA

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OEA was synthesized in our lab as previously described [30] . MK866 was purchased from Cayman Chemical (Ann Arbor, MI, USA) while other chemicals were sourced from Sigma-Aldrich (Shanghai, China).
Fan A., Wu X., Wu H., Li L., Huang R., Zhu Y., Qiu Y., Fu J., Ren J, & Zhu C. (2014). Atheroprotective Effect of Oleoylethanolamide (OEA) Targeting Oxidized LDL. PLoS ONE, 9(1), e85337.
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