Azd 3988

Manufactured by Bio-Techne

AZD-3988 is a laboratory product manufactured by Bio-Techne. It is a chemical compound used for research purposes.

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Lab products found in correlation

2 protocols using azd 3988

Synthesis and Characterization of Lipid-Lowering Compounds

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The following compounds were purchased from commercial vendors: fluvastatin (S1909, Selleck Chemicals), atorvastatin (S2077, Selleck Chemicals), lapaquistat (SC-488705, Santa Cruz Biotechnology), Ro48–8071 (10006415, Cayman Chemical), AY 9944 (14611, Cayman Chemical), NB-598 (N4536, Sigma), and AZD-3988 (4837, Tocris).
Azalanstat, SR31747, and F12511 were synthesized using previously published methods^{19 (link),49 (link)}.

Mahoney C.E., Pirman D., Chubukov V., Sleger T., Hayes S., Fan Z.P., Allen E.L., Chen Y., Huang L., Liu M., Zhang Y., McDonald G., Narayanaswamy R., Choe S., Chen Y., Gross S., Cianchetta G., Padyana A.K., Murray S., Liu W., Marks K.M., Murtie J., Dorsch M., Jin S., Nagaraja N., Biller S.A., Roddy T., Popovici-Muller J, & Smolen G.A. (2019). A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition. Nature Communications, 10, 96.

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Mitochondrial Stress Response Modulators

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Compounds were used at the following concentrations unless otherwise noted: 50 μM AZD3988 (Tocris), 30 μM A922500 (Stratech), 50 μM AZD7687 (Stratech), 70 μM T863 (Sigma), 1 μM Oligomycin (Sigma), 0.5 μM FCCP (Sigma), 1 μM Antimycin-A (Sigma), 1 μM Rotenone (Sigma), 50 μM PF-06424439 (Sigma), 5 μM Ebselen (Tocris), 1 mM Tempol, 200 μM Paraquat (Sigma), Menadione (Sigma), 100 μM Etomoxir (Sigma), 2 μM Ferrostatin-1 (Sigma), 5 μM ML385 (Selleckchem), and 1 μM ATN-224 (Cayman Chemical). Antibodies against DGAT1 (ab54037) and 4-Hydroxynonenal (ab46545) were purchased from abcam. Antibodies against Vinculin (66305-1-Ig), Beta-Tubulin (10094-1-AP), PINK1 (23274-1-AP), Parkin (14060-1-AP), SOD1 (10269-1-AP), SOD2 (24127-1-AP), SESN2 (10795-1-AP) and GAPDH (60004-1-Ig) were purchased from Proteintech. Antibodies against phospho-AMPK (50081), phospho-RAPTOR (2083), Caspase-3 (9662), phospho-ERK (4370) and GFP (2956) were purchased from Cell Signalling. The antibody against gamma-tubulin (T5326) was purchased from Sigma. The antibody against ERK2 (C-14) was from Santa Cruz Biotechnology.

Wilcock D.J., Badrock A.P., Wong C.W., Owen R., Guerin M., Southam A.D., Johnston H., Telfer B.A., Fullwood P., Watson J., Ferguson H., Ferguson J., Lloyd G.R., Jankevics A., Dunn W.B., Wellbrock C., Lorigan P., Ceol C., Francavilla C., Smith M.P, & Hurlstone A.F. (2022). Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached. Cell Reports, 39(12), 110995.

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