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2h9 isovalerylcarnitine

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2H9-Isovalerylcarnitine is a stable isotope-labeled compound used as an analytical standard in mass spectrometry applications. It is a deuterated version of isovalerylcarnitine, a naturally occurring metabolite. This product can be utilized for the development and validation of quantitative analytical methods for the detection and measurement of isovalerylcarnitine in biological samples.

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Lab products found in correlation

Hplc grade formic acid, by Thermo Fisher Scientific (2 mentions) Hplc grade ammonium acetate, by Merck Group (2 mentions) 2h3 octanoylcarnitine, by Cambridge Isotopes (2 mentions) 2h3 palmitoylcarnitine, by Cambridge Isotopes (2 mentions) Acetonitrile, by Thermo Fisher Scientific (2 mentions) Methanol, by Thermo Fisher Scientific (2 mentions) L arginine, by Cambridge Isotopes (1 mentions) L methionine, by Cambridge Isotopes (1 mentions) 2h9 myristoylcarnitine c14, by Cambridge Isotopes (1 mentions) L alanine, by Cambridge Isotopes (1 mentions) Dl glutamic acid, by Cambridge Isotopes (1 mentions) L citrulline, by Cambridge Isotopes (1 mentions) L phenylalanine, by Cambridge Isotopes (1 mentions) L tyrosine, by Cambridge Isotopes (1 mentions) L valine, by Cambridge Isotopes (1 mentions) L leucine, by Cambridge Isotopes (1 mentions) 2h9 carnitine, by Cambridge Isotopes (1 mentions) 2h3 acetylcarnitine, by Cambridge Isotopes (1 mentions) 2h3 propionylcarnitine, by Cambridge Isotopes (1 mentions) 2h3 butyrylcarnitine, by Cambridge Isotopes (1 mentions)

2 protocols using 2h9 isovalerylcarnitine

1

Comprehensive Lipid and Metabolite Analysis

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PC(12:0/13:0), PE(12:0/13:0), SM(d18:1/12:0) and Cer(d18:1/12:0) were purchased from Avanti Polar Lipids (Alabaster, AL, USA). Stable isotope labeled references were purchased from Cambridge Isotope Laboratories (Andover, MA, USA), including: Glycine (2-13C, 15N), L-Alanine (2,3,3,3-D4), L-Valine (D8), L-Leucine (5,5,5-D3), L-Methionine (methyl-D3), L-Phenylalanine (ring-13C6), L-Tyrosine (ring-13C6), L-Aspartic acid (2,3,3-D3), DL-Glutamic acid (2,4,4-D3), L-Ornithine: HCl (5,5-D2), L-Citrulline (5,5-D2) and L-Arginine (5-13C, 4,4,5,5-D4). Deuterium-labeled carnitine and acylcarnitines (NSK-B set) were purchased from Cambridge Isotope Laboratories (Tewksbury, MA, USA), including 2H3-Acetylcarnitine (C2), 2H3-Propionylcarnitine (C3), 2H3-Butyrylcarnitine (C4), 2H9-Isovalerylcarnitine (C5), 2H3-Octanoylcarnitine (C8), 2H9-Myristoylcarnitine (C14), and 2H3-Palmitoylcarnitine (C16). HPLC-grade ammonium acetate was purchased from Sigma-Aldrich (St. Louis, MO, USA), and HPLC-grade formic acid and acetonitrile were purchased from Thermo Fisher Scientific (Waltham, MA, USA). All solutions were prepared by LC-MS ultra-pure water.
Zhao H., Xi C., Tian M., Lu X., Cai T.J., Li S., Tian X.L., Gao L., Liu H.X., Liu K.H, & Liu Q.J. (2020). Identification of Potential Radiation Responsive Metabolic Biomarkers in Plasma of Rats Exposed to Different Doses of Cobalt-60 Gamma Rays. Dose-Response, 18(4), 1559325820979570.
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2

Analytical Reference Standards for Acyl-Carnitines

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Analytical reference standards of 29 acyl-carnitines (Sigma-Aldrich, Co., St. Louis, MO, USA) were employed for quality control of compounds in samples. We defined acyl-carnitines and major acyl-carnitine fractions as free-, short-, medium-, or long-chain acyl-carnitines according to the length of carbon chains in the molecular structure (i.e., free carnitine: C0, short-chain: C2-C5, medium-chain: C6-C12, long-chain: C14-C18)29 (link),30 (link). Deuterium-labeled carnitine and acyl-carnitines (NSK-B Set, Cambridge Isotope Laboratories, Inc., Tewksbury, MA, USA) were used as internal standards, including 2H9-carnitine (free carnitine, CN), 2H3-acetylcarnitine (C2), 2H3-propionylcarnitine (C3), 2H3-butyrylcarnitine (C4), 2H9-isovalerylcarnitine (C5), 2H3-octanoylcarnitine (C8), 2H9-myristoylcarnitine (C14), and 2H3-palmitoylcarnitine (C16). HPLC-grade ammonium acetate was purchased from Sigma-Aldrich (St. Louis, MO, USA); HPLC-grade formic acid and methanol were supplied by Thermo Fisher Scientific (Waltham, MA, USA); pure water was purchased from Wahaha Co., Ltd. (Hangzhou, China).
Cao B., Wang D., Pan Z., Brietzke E., McIntyre R.S., Musial N., Mansur R.B., Subramanieapillai M., Zeng J., Huang N, & Wang J. (2019). Characterizing acyl-carnitine biosignatures for schizophrenia: a longitudinal pre- and post-treatment study. Translational Psychiatry, 9, 19.
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