Propylene glycol

Manufactured by Samchun

Propylene glycol is a colorless, odorless, and viscous liquid. It is a common chemical compound used in various industrial and commercial applications. Propylene glycol serves as a core functional ingredient in laboratory equipment, providing essential properties such as solubility and stabilization.

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Lab products found in correlation

4 protocols using propylene glycol

Timolol Maleate Topical Formulation

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Timolol maleate as active pharmaceutical ingredient (API (was purchased from Sina darou Laboratories (Tehran, Iran). Polyethylene glycol 4000 and propylene glycol 99.0% were provided by Samchun Chemicals (Gyeonggi-do, Korea). Poly (1-carboxyethylene) or carbopol® 934 as a thickener were purchased from Serva FeinBiochemica (Heidelberg, Germany). Furthermore, triethanolamine as pH adjusters was supplied by Merck (Darmstadt, Germany).

Nabi-Meybodi M., Sahebnasagh A., Hakimi Z., Shabani M., Shakeri A.A, & Saghafi F. (2022). Effects of topical timolol for the prevention of radiation-induced dermatitis in breast cancer: a pilot triple-blind, placebo-controlled trial. BMC Cancer, 22, 1079.

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Formulation Ingredients for Topical Applications

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Niacinamide 99.5% (nicotinamide, NAC), hexadecyltrimethylammonium bromide 98.0%, benzalkonium chloride 95.0%, alkyltrimethylammonium bromide 95.0%, dodecylamine 98.0%, cetylpyridinium chloride 98.0%, sodium dodecyl sulfate (SDS) 98.5%, Tween®80 (polysorbate 80), Tween®20 (polysorbate 20), Span®20 (sorbitan laurate), phosphate-buffered saline (PBS pH 7.4) powder, and Strat-M® Membrane (25 mm) were purchased from Sigma-Aldrich Inc. (St. Louis, MO, USA). TEGOSOFT® CT was obtained from Evonik (Essen, Germany). Butylene glycol 99.0% (BG), dipropylene glycol 97.0% (DPG), and propylene glycol 99.0% (PG) were purchased from Samchun Pure Chemical Co., Ltd. (Pyeongtaek, Korea). Polyethylene glycol 400 was purchased from Junsei Chemical Co., Ltd. (Tokyo, Japan). Polyoxyethylene (1 6 0) and polyoxylpropylene (30) glycol (Kolliphor® P188), polyoxyethylene (1 9 6) and polyoxylpropylene (67) glycol (Kolliphor® P407), Polyethylene glycol 6000 (PEG6000), polyvinyl alcohol-polyethylene glycol graft copolymer (Kollicoat® IR), polyvinylpyrrolidone (Kollidon® K12), macrogol 15 hydroxystearate (Kolliphor® HS 15), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®), and D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) were obtained from BASF (Ludwigshafen, Germany). PVP/VA S-630 was obtained from ISP Technologies Inc. (Wayne, NJ, USA).

Sohn J.S, & Choi J.S. (2023). Development and evaluation of niacinamide transdermal formulation by artificial membrane permeability. Saudi Pharmaceutical Journal : SPJ, 31(7), 1229-1236.

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Formulation and Characterization of Lipid-based Delivery Systems

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SMM was purchased from Sigma Chemical Co (St. Louis, MO, USA). Propylene glycol (PG) was purchased from Samchun Chemical Co., Ltd (Pyeongtaek, Korea). Isopropyl myristate (IPM), oleic acid, and limonene were purchased from Sigma Chemical Co. HPLC grade m ethanol, ethanol and acetonitrile were purchased from Thermo Fisher Scientific Co (Pittsburgh, PA, USA).

Kim K.T., Kim J.S., Kim M.H., Park J.H., Lee J.Y., Lee W., Min K.K., Song M.G., Choi C.Y., Kim W.S., Oh H.K, & Kim D.D. (2017). Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-l-Methionine. Biomolecules & Therapeutics, 25(4), 434-440.

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Synthesis and Formulation of ZPF Compounds

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(S)-ZPF, (R)-ZPF and (RS)-ZPF were synthesized from the laboratory of Prof. S.H. Jung (Chungnam National University, Daejeon, Korea). d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS) and 2-hydroxypropyl-β-cyclodextrin (HPCD) were purchased from Sigma-Aldrich (Steinheim, Switzerland). Poloxamer 188 and poloxamer 407 were purchased from BASF SE (Ludwigshafen, Germany). Cremophor EL, polyethylene glycol (PEG) 400, PEG 600, Tween 80, and propylene glycol (PG) were purchased from Samchun Chemical Co., Ltd. (Pyungtaek, Korea). HPLC-grade acetonitrile, methanol, n-hexane, and 2-propanol were from JT Baker (Phillipsburg, NJ, USA). Distilled water (DW) was used in this study. All solvents were analytical grade and used without further purification.

Pham C.V., Baek J.S., Park J.H., Jung S.H., Kang J.S, & Cho C.W. (2018). A thorough analysis of the effect of surfactant/s on the solubility and pharmacokinetics of (S)-zaltoprofen. Asian Journal of Pharmaceutical Sciences, 14(4), 435-444.

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