Multihance

Manufactured by Bracco

Sourced in Italy, Germany, United States, China

MultiHance is a contrast agent used in magnetic resonance imaging (MRI) procedures. It is a paramagnetic agent that enhances the visualization of internal body structures during the MRI scan. The core function of MultiHance is to improve the contrast between different tissues, allowing for better detection and evaluation of potential abnormalities.

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Lab products found in correlation

Magnevist, by Bayer (19 mentions) Dotarem, by Guerbet (12 mentions) Magnetom avanto, by Siemens (10 mentions) Achieva, by Philips (9 mentions) Gadavist, by Bayer (8 mentions) Signa hdxt, by GE Healthcare (8 mentions) Prohance, by Bracco (7 mentions) Ingenia, by Philips (6 mentions) Magnetom skyra, by Siemens (6 mentions) Gadovist, by Bayer (6 mentions) Signa hdx, by GE Healthcare (5 mentions) Espree, by Siemens (5 mentions) Tim trio, by Siemens (5 mentions) Magnetom trio, by Siemens (4 mentions) Magnetom vida, by Siemens (4 mentions) Magnetom verio, by Siemens (4 mentions) Primovist, by Bayer (4 mentions) Ingenia 3t, by Philips (3 mentions) Ingenia 1.5t, by Philips (3 mentions) Mr750, by GE Healthcare (3 mentions)

Spelling variants of this product

MultiHance 0.5 mmol/mL (3 citations) Gadolinium-BOPTA Multihance (3 citations)

222 protocols using multihance

Multiparametric Breast MRI Imaging Protocol

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MRI examinations were performed using a 1.5 T whole body imaging system (Gyroscan Intera, Philips Medical System, The Netherlands) and a breast coil. Patients were imaged in the prone position with T2-weighted and diffusion-weighted imaging (DWI) (b0, b600) sequences, and a 3D gradient echo axial T1-weighted sequence with fat suppression (SPAIR). Scan parameters were TR/TE = 4.8/2.4 ms, flip angle = 10°, FOV = 355 × 355 mm, matrix 320 × 320, slice thickness 2.5 mm, voxel size 0.65 × 0.65 × 1.25 mm after reconstruction. The anatomic study was followed by a dynamic study. Patients received 0.1 mmol/kg of gadobenate dimeglumine (Multihance, Bracco Imaging, Germany) followed by 30 mL saline flush injected at a rate of 2 mL/s with an automated injector. One pre- and five post-injection images were acquired with a temporal resolution of approximately 60 s. The total acquisition time for the protocol was about 6 min. Analyses were performed on subtracted images, i.e. the residual difference image obtained after the second post-contrast image has been subtracted from the pre-contrast image.

Michoux N., Van den Broeck S., Lacoste L., Fellah L., Galant C., Berlière M, & Leconte I. (2015). Texture analysis on MR images helps predicting non-response to NAC in breast cancer. BMC Cancer, 15, 574.

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Contrast Agents in MRI Imaging

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Contrast agents were used as supplied by the manufacturer: linear GBCAs such as gadodiamide (Omniscan; GE Healthcare Buchler, Braunschweig, Germany), gadopentetate dimeglumine (Gd-DTPA, Magnevist; Bayer-Vital, Leverkusen, Germany), and gadobenate dimeglumine (Multihance; Bracco, Konstanz, Germany) as well as macrocyclic GBCAs such as gadobutrol (Gadovist; Bayer-Vital) and gadoterate meglumine (Gd-DOTA, Dotarem; Guerbet, Sulzbach/Taunus, Germany). All reagents used were of the highest purity. Deionized water was obtained from a Milli-Q system (Waters, Eschborn, Germany).

Frenzel T., Apte C., Jost G., Schöckel L., Lohrke J, & Pietsch H. (2017). Quantification and Assessment of the Chemical Form of Residual Gadolinium in the Brain After Repeated Administration of Gadolinium-Based Contrast Agents: Comparative Study in Rats. Investigative Radiology, 52(7), 396-404.

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Quantitative Hemodynamic Assessment of Blood-Brain Barrier Modulation

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In order to achieve quantitative hemodynamic measurements of blood-brain barrier opening and permeability, a bolus of gadobenate dimeglumine (Multihance, Bracco Diagnostics Inc. Monroe Township, NJ 08831, USA) was injected and dynamic contrast enhancement (DCE) MR imaging was performed immediately, Day 1, and Day 7 post treatment (TR/ TE = 65/3 ms, average = 2, field of view 25 mm, flip angle 35°, matrix size=68×128, slice thickness=1.3 mm).
Post-contrast T1-weighted imaging (TR/ TE =720/11 milliseconds, 4 averages, field of view=25 mm, matrix size=248×512, slice thickness=0.6 mm) was obtained to depict the area of contrast-enhancement in the hippocampus.
T2*- weighted gradient echo imaging (repetition time/echo time [TR/TE]=391/20 ms, flip angle 20°, 3 averages, field of view 25 mm, matrix size=256×256, slice thickness 0.8 mm) was performed immediately after sonication to evaluate possible hemorrhagic complications.
To assess resulting lesions during the follow-up period, T2-weighted fast spin echo (FSE) images (TR/TE=4800/85 ms, 1 average, field of view=25 mm, matrix size=240×256, slice thickness 1.2 mm) were acquired at three time points: immediately, Day 1 and Day 7 after sonication.

Zhang Y., Liao C., Qu H., Huang S., Jiang H., Zhou H., Abrams E., Habte F.G., Yuan L., Bertram E.H., Lee K.S., Pauly K.B., Buckmaster P.S, & Wintermark M. (2018). Testing different combinations of acoustic pressure and doses of quinolinic acid to induce focal-neuron loss in mice using transcranial low-intensity focused ultrasound. Ultrasound in medicine & biology, 45(1), 129-136.

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MRI Breast Imaging Protocol

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All MRIs in this study were acquired using a 1.5 Tesla (Signa HDx, GE Healthcare, Little Chalfont, United Kingdom[44]; Signa HDxt, GE Healthcare[5]; MAGNETOM Avanto, Siemens, Munich, Germany[37]) or 3.0 Tesla scanner (Signa HDx, GE Healthcare[167]; MAGNETOM Trio, Siemens, Munich, Germany[25]) scanner using a breast coil (Invivo, Orlando, FL). More details were illustrated in Table 1. Each case had the following sequences: nonfat-saturated T1-weighted, fat-saturated T2-weighted sequence, and pre-contrast followed by three dynamic post-contrast T1-weighted gradient echo series with fat suppression after intravenous administration of gadopentetate dimeglumine (Magnevist, Bayer Health Care, Berlin, Germany) or gadobenate dimeglumine (MultiHance, Bracco, Milan, Italy). Contrast load was determined using a weight based dosing protocol (0.2 mL/kg). The estrogen receptor (ER), progesterone receptor (PR), and HER2-neu status were obtained from the initial breast biopsy pathology report.

Zhu Z., Albadawy E., Saha A., Zhang J., Harowicz M.R, & Mazurowski M.A. (2019). Deep Learning for identifying radiogenomic associations in breast cancer. Computers in biology and medicine, 109, 85-90.

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Dynamic Contrast-Enhanced 3D Radial Imaging

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The dynamic contrast enhanced 3D radial scan (CE VIPR) was obtained using the following imaging parameters: FOV = 22cm³, TR/TE = 3.0/0.4 ms, bandwidth = 125 kHz, 64 points from the center to the edge of the k-space for each projection, frame rate 0.5s; total acquisition window = 0.75 seconds, spatial resolution 1.7×1.7×1.7mm. Gadobenate dimeglumine (MultiHance, Bracco Diagnostics, Princeton, New Jersey) was injected at 3 mL/s, and the contrast dose was 0.1 ml/kg followed by a 20-mL saline flush.

Clark Z., Johnson K.M., Wu Y., Edjlali M., Mistretta C., Wieben O, & Turski P. (2016). Accelerated Time Resolved Contrast Enhanced MRA of Dural Arteriovenous Fistulas using Highly Constrained Reconstruction of Sparse Cerebrovascular Datasets. Investigative radiology, 51(6), 365-371.

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MRI Protocol for Prostate Cancer Evaluation

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MRI examinations were performed using 1.5‐T (n = 37) and 3‐T (n = 10) Philips MRI systems (Ingenia, Achieva; Philips Healthcare, Amsterdam, Netherlands). The acquired sequences included axial T1WI and fat‐suppressed T2WI, three‐dimensional (3D) contrast‐enhanced fat‐suppressed T1WI, and DWI using echo‐planar imaging. DWI was performed with b‐values of 0 and 1000 seconds/mm² and the following parameters: repetition time (TR) range, 5000‐9000 ms; echo time (TE) range, 58‐90 ms; number of excitations, 1; slice thickness/gap, 4‐5/0‐1 mm; field of view, 240 × 240 mm; pixel size, 1.5 × 1.5 mm, and three diffusion directions. DCE‐MRI was performed using a 3D T1‐weighted (3D‐T1) fast field echo and the following parameters: TR, 4.8 ms; TE, 2 ms; flip angle, 30°; slice thickness/gap, 5/0 mm; field of view, 200 × 200 mm²; voxel size/matrix, 1.0 × 1.0 × 5.0 mm³/240 × 240; number of excitations, 1; number of slices per dynamic scan, 30; temporal resolution, 8.4 s; and total acquisition time, 4 minutes and 23 seconds. An intravenous bolus of 20 ml gadobenate dimeglumine contrast (Multihance, Bracco Diagnostics, Milan, Italy) was administered through a peripheral arm vein using a power injector at a flow rate of 5.0 ml/second, followed by a 20‐ml saline flush.

Kurokawa R., Kurokawa M., Holmes A., Baba A., Bapuraj J., Capizzano A., Kim J., Srinivasan A, & Moritani T. (2022). Skull metastases and osseous venous malformations: The role of diffusion‐weighted and dynamic contrast‐enhanced MRI. Journal of Neuroimaging, 32(6), 1170-1176.

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In Vivo Magnetic Resonance Imaging of Mice

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Mice were anesthetized with isoflurane and restrained in a 3-point head holder. Images were acquired with a 4.7 T small-animal Agilent/Varian DirectDrive1 scanner using an actively decoupled volume coil (transmit) and 1.5 cm surface coil (receive). Before loading into the magnet, mice were given an intraperitoneal injection of 0.5 mL MultiHance (gadobenate dimeglumine, Bracco Diagnostics Inc, Princeton, NJ) contrast agent diluted 1:10 in sterile saline. All data were collected with a field of view of 15 × 15 mm², 21 contiguous slices with a thickness of 0.5 mm, imaging matrix of 128 by 128 and 4 averages. Spin-echo T2-weighted (TR = 2000 ms, TE = 50 ms), spin-echo T1-weighted (TR = 650 ms, TE =20 ms), and gradient-echo proton-density (PD) weighted (TR = 500 ms, TE = 5 ms, flip angle = 20) datasets were acquired, in this order, for each mouse at each time point.

Perez-Torres C.J., Yuan L., Schmidt R.E., Rich K.M., Drzymala R.E., Hallahan D.E., Ackerman J.J, & Garbow J.R. (2015). Specificity of Vascular Endothelial Growth Factor Treatment for Radiation Necrosis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 117(2), 382-385.

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Cervical Spine MRI with Contrast

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All but 4 patients (2%) included in this study underwent c-MRI with and without intravenous contrast administration. Of the 4 patients who underwent c-MRI without intravenous contrast, 1 underwent MR angiography of the neck with intravenous contrast, which allowed postcontrast assessment of the cervical spine.
MRI was performed on either a 3.0-T (TIM Trio, Siemens Healthcare) or 1.5-T (Avanto, Siemens Healthcare; or Intera, Phillips) using a head-neck array coil for cervical spine imaging. A standard dose (0.1 mmol/kg) of gadobenate dimeglumine (MultiHance, Bracco Diagnostics) was injected at 2–3 ml/sec. The standardized MRI protocol obtained included a precontrast sagittal T1-weighted (TE 10 msec, TR 400 msec, flip angle (FA) 90°, slice thickness 3 mm), sagittal T2-weighted (TE 90 msec, TR 2500 msec, FA 90°, slice thickness 3 mm), axial T2-weighted (TE 90 msec, TR 5300 msec, FA 90°, slice thickness 3 mm), and/or postcontrast sagittal T1-weighted (TE 10 msec, TR 400 msec, FA 90°, slice thickness 3 mm) and axial T1-weighted (TE 10 msec, TR 1600 msec, FA 90°, slice thickness 3 mm) images of the cervical spine.

Sadigh G., Holder C.A., Switchenko J.M., Dehkharghani S, & Allen J.W. (2017). Is there added value in obtaining cervical spine MRI in the assessment of nontraumatic angiographically negative subarachnoid hemorrhage? A retrospective study and meta-analysis of the literature. Journal of neurosurgery, 129(3), 670-676.

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Comprehensive Abdominal MRI Protocol

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The MRI examinations were performed in a 3T MRI scanner (Magnetom Skyra; Siemens) with the patient in a supine position using a multichannel phased-array body coil covering the whole abdomen and pelvis. Before the scan, a bellyband was wrapped around the patient’s abdomen to reduce the motion artefacts. The MRI protocol included conventional static MRE sequences and DCE-MRI sequences. First, static MRE was applied: Coronal and axial 2D fat-suppressed T2-weighted half-Fourier acquisition single-shot turbo spin echo, two axial T2-weighted True FISP (Trufi) sequences with and without fat saturation, DWI (b = 50/800), and unenhanced 3D fat-suppressed T1-weighted volumetric interpolated breath hold examination (3D-VIBE). After the intravenous administration of a gadolinium-based contrast medium (0.1 mL/kg bodyweight of gadobenate dimeglumine, MultiHance, Bracco Diagnostics) at an injection rate of 2 mL/s followed by a subsequent injection of the same amount of normal saline, the Twist VIBE-based DCE sequence was continuously applied followed by the coronal and axial T1-weighted Dixon sequence 3 min after administration. The detailed parameters of the MRI protocol are given in Table 1.

Wu Y.C., Xiao Z.B., Lin X.H., Zheng X.Y., Cao D.R, & Zhang Z.S. (2020). Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging in the activity staging of terminal ileum Crohn's disease. World Journal of Gastroenterology, 26(39), 6057-6073.

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Porcine MRI for Biomedical Research

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Pigs were scanned used a clinical 3 T Trio MRI with an integrated spine coil (Siemens Medical Solutions, Malvern, PA, USA) using standard clinical sequences including T1-weighted, T2-weighted, and T1-weighted post-gadolinium (0.1 mmol/kg intravenous, Multihance, Bracco Diagnostics, Italy). Scans were reviewed and processed using RadiAnt DICOM Viewer (Medixant, Poznań, Poland) [10 (link)].

Tora M.S., Neill S.G., Lakhina Y., Assed H., Zhang M., Nagarajan P.P., Federici T., Gutierrez J., Hoang K.B., Du Y., Lei K, & Boulis N.M. (2023). Tumor microenvironment in a minipig model of spinal cord glioma. Journal of Translational Medicine, 21, 667.

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