Signa hdxt 3.0 t mri system

A Signa HDxt 3.0 T MRI system (GE Healthcare Life Sciences, Chicago, IL, USA) was used to perform the breast examinations of all patients with the prone position. A dedicated eight-channel double-breast coil was used for the DCE-MRI scans of all patients, which were transverse. For each scan, a pre-contrast series was initially performed and eight post-contrast series were then conducted after an intravenous injection of the contrast agent [0.5 mmol/mL of Omniscan™ (gadodiamide); GE Healthcare, Berlin, Germany] at 4 mL/s (0.15 mmol/kg body weight) with an equal volume of saline. The parameters of the scan were as follows: repetition time = 7.42 ms, echo time = 4.25 ms, flip angle = 15°, slice thickness = 2.20 mm, spacing between slices = 2.20 mm, inversion time = 20 ms, image matrix = 1024 × 1024, time per volume = 80 s, slice number = 78, and field of view = 340 × 340 mm². Eight post-contrast images subtracted the pre-contrast images to obtain the images of eight subtraction.

Neuroimaging data from patients with HFS and healthy controls were acquired using the GE Signa HDxt 3.0-T MRI system with an eight-channel head coil. Three-dimensional anatomical images were acquired using a magnetization-prepared rapid acquisition gradient echo (MPRAGE) sequence [time of repetition (TR) = 10.7 ms, time of echo (TE) = 4.9 ms, flip angle (FA) = 15°, in-plane resolution = 1 × 1 × 1 mm, matrix size = 256 × 256, field of view (FOV) = 256 × 256 mm, scan duration = 4 min and 51 s]. Next, a resting-state fMRI scan was collected for each subject using gradient echo–echo planar imaging (GRE-EPI; 150 volumes per slice, TR = 2,000 ms, TE = 35 ms, FA = 90°, in-plane resolution = 3.75 × 3.75 × 4 mm, matrix size = 64 × 64, FOV = 240 × 240 mm). Participants were asked to keep their eyes closed and to remain awake during resting-state fMRI. Finally, diffusion-tensor imaging was also collected after the T1-weighted and resting-state fMRI, but was not discussed in this study.

Routine MRI and enhanced gradient echo T2 star weighted angiography (ESWAN) were performed using the GE signa HDXT 3.0T MRI system with 8-channel head coil. All the scan sequence parameters were set the same. The specific scanning sequence and parameters are shown in Table 1.