Lung injury was obtained by repeated i.v. bolus administration of oleic acid emulsion with glucose solution (ratio 1:1, Oleic acid PhEur, 75,096, Sigma Aldrich, Munich, Germany and Glucose 5%, B. Braun Melsungen AG, Melsungen, Germany) until the ratio of partial pressure of oxygen in arterial blood (PaO2)/fraction of inspired oxygen (FiO2) was below 200 mmHg at an FIO2 of 1.0. Following the Acute Respiratory Distress Syndrome Clinical Network (ARDSnet) recommendations, PEEP and FiO2 were tuned such as to maintain a PaO2 > 60 mmHg: in such a case, first FiO2 was reduced to 0.8 and subsequently PEEP was reduced stepwise by 2 cm H2O in order to keep absorption atelectasis and peak pressure at a minimum.
Glucose 5
Manufactured by B. Braun
Sourced in Germany
Glucose 5% is a sterile, non-pyrogenic solution that contains 5% dextrose in water for injection. It is intended for intravenous administration as a source of water, calories, and electrolytes.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using glucose 5
1
Oleic Acid-Induced Lung Injury Model
2
Evaluation of Contrast Agents for Imaging
Check if the same lab product or an alternative is used in the 5 most similar protocols
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The following five fluids were used as contrast agents:
NaCl 5.85%; ready-to-use hypertonic (1 mmol/mL) sodium-chloride solution, clinically used for the substitution of sodium (Natriumchlorid 5.85% Braun Mpc, B. Braun Melsungen AG, Melsungen, Germany).
NaBic (sodium-bicarbonate) 8.4%, ready-to-use hypertonic buffer solution, clinically used for correction of the acid-base balance (Natriumhydrogencarbonat 8.4%, B. Braun Melsungen AG, Melsungen, Germany).
Jonosteril; ready-to-use iso-tonic, balanced crystalloid solution, clinically used for intravascular volume replacement (Jonosteril®, Fresenius Kabi, Bad Homburg, Germany).
Glucose 5%; ready-to-use ion-free isotonic glucose solution, clinically used as carrier solution for intravenous drug administration (Glucose 5%, B. Braun Melsungen AG, Melsungen, Germany).
Iomeprol 400 mg/mL; ready-to-use non-ionic but iodinated X-ray contrast medium, clinically used for angiography (Imeron® 400 MCT, Bracco Imaging Deutschland GmbH, Konstanz, Germany).
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