Patients and controls were positioned in the scanner and were told to relax with their eyes closed. They were immobilized with a custom-fit blue bag vacuum mold (Medical Intelligence, Schwabmünchen, Germany) to prevent motion artifacts. Earplugs and noise-reduction headphones were used to attenuate scanner noise. The functional run required 6 minutes to complete.
Images were acquired on a General Electric Signa 3T MR Scanner (General Electric Healthcare, Fairfield, CT) using a whole-body radiofrequency coil for signal excitation and quadrature 8-channel coil for reception. Resting-state fMRI data consisted of 120 volumes of a repeated gradient-echo echo planar imaging T2∗-weighted sequence whose parameters were repetition time = 3 seconds, echo time = 28 milliseconds, voxel dimensions = 2.7 × 2.7 × 2.8 mm, 39 oblique ACPC-oriented slices, flip angle = 90°, and 6 dummy scans.
For the structural image, a high-resolution, 3-dimensional T1-weighted gradient Echo-SPGR was acquired with the following parameters: repetition time = 9.2 milliseconds, echo time = 4.128 milliseconds, inversion time = 500 milliseconds, field of view = 240 mm, acquisition matrix = 240 × 240, slice thickness = 1 mm, full brain coverage, resolution = 1 × 1 × 1 mm, flip angle = 120°, and 166 sagittal slices.
Images were acquired on a General Electric Signa 3T MR Scanner (General Electric Healthcare, Fairfield, CT) using a whole-body radiofrequency coil for signal excitation and quadrature 8-channel coil for reception. Resting-state fMRI data consisted of 120 volumes of a repeated gradient-echo echo planar imaging T2∗-weighted sequence whose parameters were repetition time = 3 seconds, echo time = 28 milliseconds, voxel dimensions = 2.7 × 2.7 × 2.8 mm, 39 oblique ACPC-oriented slices, flip angle = 90°, and 6 dummy scans.
For the structural image, a high-resolution, 3-dimensional T1-weighted gradient Echo-SPGR was acquired with the following parameters: repetition time = 9.2 milliseconds, echo time = 4.128 milliseconds, inversion time = 500 milliseconds, field of view = 240 mm, acquisition matrix = 240 × 240, slice thickness = 1 mm, full brain coverage, resolution = 1 × 1 × 1 mm, flip angle = 120°, and 166 sagittal slices.