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Etonogestrel

Manufactured by Merck Group
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Sourced in France

Etonogestrel is a synthetic progestin used in various pharmaceutical products. It is a chemical compound that functions as a contraceptive agent. The core function of Etonogestrel is to prevent pregnancy by inhibiting ovulation and thickening the cervical mucus.

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Lab products found in correlation

Levonorgestrel, by Merck Group (1 mentions) Medroxyprogesterone acetate, by Merck Group (1 mentions) Norethindrone, by Merck Group (1 mentions) Ethinyl estradiol, by Merck Group (1 mentions) Progesterone, by Abbott (1 mentions) Dansyl chloride, by Merck Group (1 mentions) Acetonitrile, by Thermo Fisher Scientific (1 mentions) Progesterone, by Merck Group (1 mentions) Methanol, by Thermo Fisher Scientific (1 mentions) Testosterone d3, by Merck Group (1 mentions) N butylchloride, by Thermo Fisher Scientific (1 mentions) Sodium hydroxide (naoh), by Thermo Fisher Scientific (1 mentions) Estradiol, by Merck Group (1 mentions) Ammonium acetate, by Merck Group (1 mentions) Formic acid, by Merck Group (1 mentions) Sodium bicarbonate, by Merck Group (1 mentions) Letrozole, by Merck Group (1 mentions) Exemestane, by Merck Group (1 mentions) Ammonium hydroxide, by Avantor (1 mentions) Medroxyprogesterone, by Merck Group (1 mentions)

3 protocols using etonogestrel

1

Quantitative Analysis of Steroid Hormones

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We purchased etonogestrel, levonorgestrel, medroxyprogesterone acetate, norethindrone, progesterone, testosterone-d3, estradiol, ethinyl estradiol, dansyl chloride, sodium bicarbonate, ammonium acetate and formic acid from Sigma-Aldrich. estradiol-d5 was purchased from CDN Isotopes. progesterone and estradiol stock solutions were purchased from Abbott Laboratories. Water, methanol, acetonitrile, N-butylchloride, and sodium hydroxide were purchased from Fisher Scientific. We purchased double-stripped human serum from Golden West Biologicals.
Zhang J., Tang C., Oberly P.J., Minnigh M.B., Achilles S.L, & Poloyac S.M. (2019). A Sensitive and Robust UPLC-MS/MS Method for Quantitation of Estrogens and Progestogens in Human Serum. Contraception, 99(4), 244-250.
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2

Etonogestrel and Fluoxetine Preparation

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Etonogestrel (3-ketodesogestrel and fluoxetine were purchased from Sigma-Aldrich (Saint-Quentin Fallavier, France). For in vivo experiments, Etonogestrel was dissolved in oil. For ex vivo experiments, fluoxetine was prepared in saline and for Etonogestrel was dissolved in dimethylsulfoxide with a final concentration dimethylsulfoxide at 0.01%.
Casciato A., Bianchi L., Reverdy M., Joubert F., Delucenay-Clarke R., Parrot S., Ramanantsoa N., Sizun E., Matrot B., Straus C., Similowski T., Cayetanot F, & Bodineau L. (2023). Serotonin and the ventilatory effects of etonogestrel, a gonane progestin, in a murine model of congenital central hypoventilation syndrome. Frontiers in Endocrinology, 14, 1077798.
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3

Comprehensive LC-MS/MS Steroid Analysis

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Estrone-2,3,4-13C3, BCR576, 17-α-estradiol, E2 (E1024), E1 (E9750 and E1274), desogestrel, etonogestrel, medroxyprogesterone, fulvestrant, tamoxifen, exemestane, and letrozole were from Sigma Aldrich. All estrogen analytes had chemical and isotopic purity greater than 99%. Tam-N-ox, Z-4′Endoxifen, Z-Endoxifen, NDtam, NNDDtam, 4′OHtam, z-α-OHtam, cis-β-OHtam, and 17β-hydroxy exemestane were from Toronto Research Chemicals Inc. Z-4OHtam was from Santa Cruz Biotechnology. E2 (L03801) was from Alfa Aeser. 17-β-Estradiol-2,3,4-13C3, CRM E075 for E1, and CRM-E060 for E2 were from Cerillant. Methanol, ammonium hydroxide, and methyl tert-butyl ether (MTBE) were from VWR. Hexane was from Fischer Scientific.
Steroid-depleted human serum (SDHS) SF236-7 was from BBI Solutions (Crumlin, UK), or was prepared in-house from pooled serum using dextran-coated charcoal. Intralipid was from Fresenius Kabi.
Bertelsen B.E., Kellmann R., Viste K., Bjørnevik A.T., Eikesdal H.P., Lønning P.E., Sagen J.V, & Almås B. (2020). An Ultrasensitive Routine LC-MS/MS Method for Estradiol and Estrone in the Clinically Relevant Sub-Picomolar Range. Journal of the Endocrine Society, 4(6), bvaa047.
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