Milli q advantage system

Manufactured by Merck Group

Sourced in United States, Japan

The Milli-Q Advantage system is a water purification solution that produces high-quality ultrapure water. It utilizes a combination of filtration and ion exchange technologies to remove impurities and deliver consistently pure water for laboratory applications.

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Milli-Q system (3101 citations) Milli-Q (1428 citations) Milli-Q Advantage A10 system (119 citations) Milli-Q Advantage A10 water purification system (57 citations) Milli-Q Advantage (24 citations) Milli-Q Advantage A10 purification system (17 citations) Milli-Q Advantage A10 ultrapure water purification system (11 citations) Milli-Q Advantage A10 System apparatus (7 citations) Milli-Q Advantage Water Purification System (4 citations) Milli-Q Advantage-0.10 purification system (4 citations)

17 protocols using milli q advantage system

Comprehensive Phytochemical Analysis Protocol

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Standards quinic acid (1), caffeic acid (2), gallic acid (4), vanillic acid (5), catechin (7), epicatechin (9), ferulic acid (13), chrysin (15), rutin (16), quercetin-3,4′-di-O-glucoside (26), kaempferol-3-O-rutinoside (28), ellagic acid (35), coumaric acid (37), eriodictyol (39), methy-O-ellagic acid (42), protocatechuic acid (44), quercetin (45), luteolin (46), kaempferol (48) betulinic acid (50) and oleanolic acid (51) were purchased from Sigma-Aldrich (St. Louis, MO, USA) (Fig. 1). LC–MS grade solvents (acetonitrile methanol and formic acid) were also purchased from Sigma–Aldrich (St. Louis, MO, USA) and used throughout the study. Ultra-pure water was produced by Milli-Q Advantage system (Millipore, Milford, MA, USA). AR grade ethanol (Merck, Darmstadt, Germany) was used in the preparation of the ethanolic extracts.Fig. 1

Chemical structures of standard compounds.

Fig. 1.

Kumar S., Singh A, & Kumar B. (2017). Identification and characterization of phenolics and terpenoids from ethanolic extracts of Phyllanthus species by HPLC-ESI-QTOF-MS/MS. Journal of Pharmaceutical Analysis, 7(4), 214-222.

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Analytical Standards for PFASs

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Analytical standards of 9 isotope-labeled
PFASs and 18 native PFASs,
including C4–C14 perfluorocarboxylic acids (PFCAs), C4–C12
perfluorosulfonic acids (PFSAs), fluorotelomer sulfonic acids (FTSAs),
and polyfluoroalkyl phosphoric acid diesters (diPAPs) (see full list
in Table S3) were obtained from Wellington
Laboratories (Guelph, ON, Canada). Ultrapure water was prepared using
a Milli-Q Advantage system (Millipore, Billerica, USA). Glacial acetic
acid (100%) was obtained from Merck (Darmstad, Germany), ammonium
acetate from Fluka (Buchs, Switzerland), and ammonium hydroxide and
hydrochloric acid from J.T. Baker (Phillipsburg, NJ, United States).
Methanol was purchased from Fisher Scientific (Leicestershire, UK)
and sodium hydroxide from VWR International (Radnor, PA, USA). Activated
carbon discs (47 mm × 2 mm) were supplied by Futamura Chemical
Co., Ltd. (Nagoya, Aichi, Japan), GF/A filters (47 mm diameter, 1.6
μm pore size) by VWR International (Radnor, PA, USA), and Sartolon
polyamide filters (47 mm diameter, pore size 0.45 μm) from Sartorius
(Göttingen, Germany). Polyurethane foam filters (47 mm diameter,
50 mm height) were obtained from Sunde Skumplast AS (Gan, Norway).
Weak anion exchange solid-phase extraction (WAX-SPE) cartridges (Oasis
WAX, 6 cc, 150 mg sorbent, 30 μm particle size) were purchased
from Waters Corp. (Milford, MA, USA).

Björklund S., Weidemann E, & Jansson S. (2024). Distribution of Per- and Polyfluoroalkyl Substances (PFASs) in a Waste-to-Energy Plant—Tracking PFASs in Internal Residual Streams. Environmental Science & Technology, 58(19), 8457-8463.

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Synthesis and Characterization of Silver Nanoparticles

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A silver nitrate standard solution (AgNO₃, 0.1 M) was purchased from Anpel Laboratory Technologies Co., Ltd. (Shanghai, China). Sodium citrate dihydrate (C₆H₅Na₃O₇·2H₂O, 99.0%), sodium borohydride (NaBH₄, 98%), R6G (C₂₈H₃₁N₂O₃Cl, 98%), ammonium molybdate tetrahydrate (H₂₄Mo₇N₆O₂₄·4H₂O, 99.9%), sodium phosphate dodecahydrate (Pi: Na₃PO₄·12H₂O, 99.9%), and sodium chloride (NaCl, 99.9%) were purchased from Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai, China). Sulfuric acid (H₂SO₄, 98%) was obtained from Shanghai Chemical Reagent Co., Ltd. (Shanghai, China). All reagents were of analytical grade and were used without further purification. All aqueous solutions were prepared using deionized water with a specific resistance of 18.2 MΩ·cm, as obtained from a Milli-Q Advantage system (Millipore, Billerica, MA, USA).

Jiang Y., Wang X., Zhao G., Shi Y., Thuy N.T, & Yang H. (2022). SERS Determination of Trace Phosphate in Aquaculture Water Based on a Rhodamine 6G Molecular Probe Association Reaction. Biosensors, 12(5), 319.

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Quantification of miRNA Expression

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Milli-Q Advantage system was purchased from Millipore (Martillac, France). CO₂ incubator was obtained from Thermo (Waltham, MA). FBS was bought from Gibco (Grand Island, NY). RPMI-1640 medium was purchased from Hyclone (Logan, UT). Lipofectamine2000 transfection reagents and TRIzol were purchased from Invitrogen (Grand Island, NY). RNA extraction kit and SYBR Green PCR kit were purchased from Tiangen Biotech co., Ltd. (Beijing, China), and MiR-200a and negative control (NC) sequences were synthesized by Ambion (Grand Island, NY). The Boyden chamber was purchase from Kylin-Bell Lab Instruments Co., Ltd. (Haimen, China).

Chen C., Yang D., Wang Q, & Wang X. (2015). Expression and Clinical Pathological Significance of miR-200a in Concurrent Cholangiocarcinoma Associated with Hepatolithiasis. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 21, 3585-3590.

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Standards of 18 Native PFASs

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Standards of 18 native PFASs,
including C4–C14 perfluorocarboxylic
acids (PFCAs), C4–C12 perfluorosulfonic acids (PFSAs), fluorotelomer
sulfonic acids (FTSAs), and polyfluoroalkyl phosphoric acid diesters
(diPAPs) as well as 9 isotope-labeled PFASs (see full list in Table S2) were obtained from Wellington Laboratories
(Guelph, ON, Canada). Methanol was obtained from Fisher Scientific
(Leicestershire, U.K.), ammonium acetate from Fluka (Buchs, Switzerland),
acetic acid from Merck (Darmstadt, Germany), ammonium hydroxide and
hydrochloric acid from J.T. Baker (Phillipsburg, NJ), and sodium hydroxide
from VWR International (Radnor, PA). Ultrapure water was prepared
using a Milli-Q Advantage system (Millipore, Billerica). Weak anion
exchange solid-phase extraction (WAX-SPE) cartridges (Oasis WAX, 6
cc, 150 mg sorbent, 30 mm particle size) were purchased from Waters
Corp. (Milford, MA). Activated carbon disks (47 mm × 2 mm) were
supplied by Futamura Chemical Co., Ltd. (Nagoya, Aichi, Japan) and
GF/A filters (47 mm diameter, pore size 1.6 μm) from VWR International
(Radnor, PA).

Björklund S., Weidemann E, & Jansson S. (2023). Emission of Per- and Polyfluoroalkyl Substances from a Waste-to-Energy Plant—Occurrence in Ashes, Treated Process Water, and First Observation in Flue Gas. Environmental Science & Technology, 57(27), 10089-10095.

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Environmental Behavior of Functionalized CNTs

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All reagents were analytical grade. NaOH and HCl were purchased from Sinopharm Chemical Reagent Co., Ltd., (Shanghai, China). Multiwall CNTs (MWNTs) and hydroxylated MWNTs (HMWNTs) were purchased from Chengdu Organic Chemistry Co., Ltd., Chinese Academy of Sciences. MWNTs and HMWNTs with outer tube diameters of 4–6 nm (named MWNT-1 and HMWNT-1), 5–15 nm (named MWNT-2 and HMWNT-2) and 20–30 nm (named MWNT-3 and HMWNT-3) were used to study the impact of diameters on their environmental behaviors. Humic acid (HA) was purchased from the International Humic Substances Society (IHSS). The chemical compositions, functional groups and results of the NMR analysis of HA (Elliott Soil, 1S102H) are presented in Table 1 [27 ]. Deionized water (DI water) was supplied by an ultra-pure water system (Milli-Q Advantage System, Millipore, Boston, MA, USA). The water resistance value was ≥18.3 MΩ·cm, and the conductivity was ≤10 us·cm⁻¹.

Fang M., Zhao T., Zhao X., Tang Z., Liu S., Wang J., Niu L, & Wu F. (2022). Effect of Tube Diameters and Functional Groups on Adsorption and Suspension Behaviors of Carbon Nanotubes in Presence of Humic Acid. Nanomaterials, 12(9), 1592.

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Transferrin Labeling and Characterization

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Sucrose (BioXtra, ≥99.5%), ammonium acetate (anhydrous, for molecular biology, ≥99%), ammonium hydroxide, titanium(IV) isopropoxide (99.999% trace metals basis), nitric acid (≥99.999% trace metals basis), and transferrin (human, powder, BioReagent) were purchased from Sigma-Aldrich (Saint Louis, MO, USA). Fluorescent transferrin (Tf680, Alexa Fluor 680 Conjugate) was purchased from ThermoFisher Scientific (Waltham, MA, USA). The electron microscopy stain Nano-W was purchased from Nanoprobes Inc. (Upton, NY, USA). Ultrapure water (Milli-Q Advantage System, Millipore, USA) was used in all solutions and suspensions and had a resistivity of 18.3 MΩ-cm prior to the addition of chemicals and precursors.

Reed N.A., Raliya R., Tang R., Xu B., Mixdorf M., Achilefu S, & Biswas P. (2019). Electrospray Functionalization of Titanium Dioxide Nanoparticles with Transferrin for Cerenkov Radiation Induced Cancer Therapy. ACS applied bio materials, 2(3), 1141-1147.

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HPLC-MS Analysis of Indole Alkaloids

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LC–MS grade solvents were purchased from Sigma-Aldrich (St. Louis, MO, USA). Ultra-pure water was produced by Milli-Q Advantage system (Millipore, USA). AR grade ethanol, purchased from Merck Millipore (Darmstadt, Germany), was used in the preparation of ethanolic extracts. Reserpine, ajmalicine, ajmaline and serpentine were purchased from Sigma-Aldrich (St. Louis, MO, USA) and yohimbine was purchased from Chem. Faces (Wuhan, Hubei, China).

Kumar S., Singh A., Bajpai V., Srivastava M., Singh B.P, & Kumar B. (2016). Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry. Journal of Pharmaceutical Analysis, 6(6), 363-373.

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Quantitative Analysis of Pharmaceutical Impurities

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All of the reference pharmaceutical standards were classified as analytical grade (>98 %). ²H₆-amitriptyline, ²H₁₀-carbamazepine, ¹³C₃¹⁵N-ciprofloxacin, ¹³C₂-ethinyl estradiol, ²H₅-fluoxetine, ¹³C₆-sulfamethoxazole, ¹³C²H₃-tramadol, and ¹³C₃-trimethoprim were obtained from Cambridge Isotope Laboratories (USA). ²H₅-oxazepam, ²H₄-risperidone, and ¹³C₂¹⁵N-tamoxifen were purchased from Sigma-Aldrich (Germany). ²H₆-codeine, ²H₄-diclofenac, ²H₄-flecainide, ²H₃-ketoprofen, ¹³C₃²H₃-naproxen, and ²H₃-paracetamol were purchased from CDN-Isotopes (Canada).
LC/MS grade methanol and acetonitrile (LiChrosolv–hypergrade) were purchased from Merck (Germany). Purified water was prepared using a Milli-Q Advantage system, including an ultraviolet radiation source (Millipore, USA).

Gentili F.G, & Fick J. (2016). Algal cultivation in urban wastewater: an efficient way to reduce pharmaceutical pollutants. Journal of Applied Phycology, 29(1), 255-262.

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Luminol Chemiluminescence Assay Protocol

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(5-amino-2,3-dihydro-1,4-phthalazinedione) was purchased from TCI (Tokyo, Japan). A luminol stock solution was prepared at a concentration of 20 mM by dissolving luminol (0.355 g) in sodium carbonate buffer (100 mL, 0.5 M, pH 10.0). The luminol stock solution was stored at 4°C in the dark. All chemicals used in this study were of analytical reagent grade or higher, and were used without further purification. The ultrapure water used in this study was obtained using an Elix 5 UV water purification system (Millipore, Tokyo, Japan) followed by a Milli-Q Advantage system (Millipore, Tokyo, Japan).

Kodamatani H., Sugihara K., Tanisue T., Kanzaki R, & Tomiyasu T. (2020). Contamination, Decomposition, and Formation of N-Nitrosodimethylamine in Water Samples at the ng/L Level of Determination. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 36(11).

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