Vereos pet ct

All digital [¹⁸F]FDG PET/CT scans of the lower abdomen were acquired on the same scanner, a Vereos PET/CT (Philips Healthcare, Best, the Netherlands). All acquisitions and reconstructions were in accordance with European Association of Nuclear Medicine (EANM) guidelines for tumor PET imaging version 2.0 [22 (link)]. Prior to PET/CT scanning, patients fasted for 6 h and were prehydrated using 1 L of water. [¹⁸F]FDG was dosed using the quadratic formula: 379 (MBq·min·bed⁻¹·kg⁻²) × [patient weight (kg)/75]²/emission acquisition duration per bed position (min·bed⁻¹) with a factor of 379 MBq·min·bed⁻¹·kg⁻². Patients received 20 mg intravenous furosemide 15 min post-injection. Patients underwent a low-dose CT scan for attenuation correction 60 (55–65) min post-injection (120 kV, 35 mA_eff), followed by a PET scan of 5 min per bed position. Reconstructed PET images had a voxel size of 4 × 4 × 4 mm. Multiparametric MRI of the lower abdomen was made on various systems, and included T2- and diffusion-weighted imaging (DWI) sequences. Patients underwent bowel preparation using a 5 ml Microlax enema three hours before imaging (Johnson and Johnson, New Brunswick, New Jersey, USA). Further details are described in Supplementary Table 1, Supplemental digital content 1, http://links.lww.com/NMC/A246.

PET/CT scans were acquired on a Vereos PET/CT (Philips Healthcare) or Ingenuity TF PET/CT (Philips Healthcare). The injected FDG activity (A, MBq) was based on the body weight of the patients (w, kg) and the acquisition time per bed position (t in seconds) using the following quadratic equation: $A=5.2\frac{w^2}{t}$ (MBq). Patients were scanned 60 min after FDG injection. Images were acquired over 10–16-bed positions—taking 72/144 s each—based on a scan from the crown to mid-thigh or the crown to the middle of the lower leg. PET data were reconstructed in a 144 × 144 matrix size with a voxel size of 4 × 4 × 4 mm³ (representing a default transaxial field of view of 576 mm), using a default 3D ordered-subset iterative time-of-flight (TOF) reconstruction technique (Vereos PET/CT reconstitution settings: 3 iterations, 15 subsets, and a 3 mm Gaussian post-smoothing filter; Ingenuity TF PET/CT reconstitution settings: 3 iterations, 43 subsets, and a relaxation parameter of 1.0), fulfilling EANM Research Ltd (EARL) accreditation specifications [10 (link)]. A non-contrast CT scan that was used for attenuation correction was obtained using the following parameters: 120 kV, 40–200 mAs rotation time of 0.5 s, and 4 mm slice thickness.