Ps 1145

Manufactured by Bio-Techne

Sourced in United States

PS 1145 is a laboratory equipment product offered by Bio-Techne. It is a precision pipette system designed for accurate liquid handling in various laboratory applications.

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Lab products found in correlation

3 protocols using ps 1145

Modulation of Inflammatory Pathways

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Cells were treated with 680C91 and CH223191 (TOCRIS Bioscience, Bristol, United Kingdom) prepared in dimethyl sulfoxide (DMSO). Alpha-naphthoflavone (Sigma-Aldrich) was diluted in methanol:ethyl acetate (3:1), and 1-D,L-methyl-tryptophan and crystalline L-kynurenine (Sigma-Aldrich) were prepared in 0.25N HCl. PS 1145 (TOCRIS Bioscience) was prepared in DMSO. IL-1β and TNF-α were obtained from eBioscience (San Diego, CA).

D’Amato N.C., Rogers T.J., Gordon M.A., Greene L.I., Cochrane D.R., Spoelstra N.S., Nemkov T.G., D’Alessandro A., Hansen K.C, & Richer J.K. (2015). A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer. Cancer research, 75(21), 4651-4664.

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Apoptosis Pathway Modulation Protocol

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Recombinant human TNFα was purchased from PeproTech (Rocky Hill, NJ, USA; Cat. #300-01A), cycloheximide from Sigma-Aldrich (St Louis, MO, USA; Cat. #C-6255), monodansylcadaverine from Sigma-Alridch (Cat. #30432), caspase-8 and 9 inhibitors from BD Pharmingen (San Jose, CA, USA; Cat. #Z-IETD-FMK-550380 and Z-LEHD-FMK-550381), and the IKK inhibitor, PS-1145 (Cat. #4569) from Tocris Bioscience (Minneapolis, MN, USA).

Gari H.H., DeGala G.D., Lucia M.S, & Lambert J.R. (2016). Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth. Oncogenesis, 5(8), e255-.

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Inhibitor Compounds for Cell Studies

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N-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK, # T4376), N-α-tosyl-L-lysine chloromethyl ketone hydrochloride (TLCK, #90182), suberoylanilide hydroxamic acid (SAHA, #SML0061), anacardic acid (#A7236), decitabine (#A3656), lipopolysaccharide (LPS from Escherichia coli O111:B4, #L4391) were purchased from Sigma-Aldrich. Carfilzomib (#S2853) and tocilizumab (#A2012) were purchased from Selleckchem. Ro-106-9920 (#1178), TPCA-1 (#2559), PS1145 (#4569), Bay11-7082 (#1744), Ruxolinitib (#7048) and Stattic (#2798) were purchased from TOCRIS bioscience. TAK-242 (# 614316) was purchased from Millipore. Etanercept was supplied by Pfizer.

Clanchy F.I., Huang Y.S., Ogbechi J., Darlington L.G., Williams R.O, & Stone T.W. (2022). Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?. Frontiers in Immunology, 13, 832989.

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