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Clodrosome encapsome

Manufactured by Encapsula Nanosciences
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Sourced in United States

Clodrosome and Encapsome are advanced laboratory equipment developed by Encapsula Nanosciences. Clodrosome is a device used for the preparation of liposomal drug formulations, while Encapsome is an instrument designed for the characterization and analysis of various nanoparticle systems. Both products are intended for use in research and development settings, but a detailed description of their core functions is not available at this time.

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Lab products found in correlation

Nanoject 2 injector, by Drummond (1 mentions)

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Clodrosome (38 citations) Encapsome (15 citations)

2 protocols using clodrosome encapsome

1

Macrophage Depletion for Infection Study

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Macrophage depletion was based on a protocol previously described (56 (link)). Briefly, 200 µL Clodronate containing liposomes and control liposomes (Clodrosome + Encapsome [Encapsula Nano Sciences]) were administered to the mice i.p. 2 d and 4 h prior to infection with bacteria. At 18 h prior to infection, IFN-γ–depleting or control antibodies were also administered to the mice.
Tuffs S.W., Goncheva M.I., Xu S.X., Craig H.C., Kasper K.J., Choi J., Flannagan R.S., Kerfoot S.M., Heinrichs D.E, & McCormick J.K. (2022). Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production. Proceedings of the National Academy of Sciences of the United States of America, 119(8), e2115987119.
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2

Clodronate Liposomes Depletion of Mosquito Hemocytes

Cited 1 time
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The day prior to CSPmut infection, naïve female mosquitoes (3–5 days old) were injected intrathoracically with either 69 nL of control liposomes or CLDs (Standard Macrophage Depletion Kit; Clodrosome® + Encapsome®; Encapsula Nano Sciences, Brentwood, TN, USA) using a Nanoject II injector (Drummond Scientific Co.). As previously described22 (link), 1:5 dilutions of liposomes and CLDs in 1 × PBS were used for the experiments. Following liposome injection, mosquitoes were infected with CSPmut parasites. The effect of clodronate liposomes on the depletion of mosquito hemocytes was determined by the expression of cell markers NimB2 (hemocytes), LRIM15 (granulocytes), and SCRB9 (oenocytoids) with real-time PCR as previously reported26 (link). The change in oocyst melanization, the number of sporozoites, and relative expression of TEP1 were determined as described above.
Zhu F., Zheng H., Chen S., Zhang K., Qin X., Zhang J., liu T., Fan Y., Wang L., Li X., Zhang J, & Xu W. (2022). Malaria oocysts require circumsporozoite protein to evade mosquito immunity. Nature Communications, 13, 3208.
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