Decitabine

Decitabine was purchased from LC laboratories (Woburn, MA, USA). Labrafac^® WL1349 (caprylic-capric acid triglycerides) and Transcutol^® HP (highly purified diethylene glycol monoethyl ether) were kindly provided by Gattefossé (Saint-Priest, France). Kolliphor^® HS15 (a mixture of free polyethylene glycol [PEG] 660 and PEG 660 hydroxystearate) was kindly supplied by BASF (Angerville, France). Sodium chloride was purchased from Prolabo (Fontenay-Sous-Bois, France). Formic acid, Tween^® 20 (sorbitan monolaurate), potassium chloride, sodium hydroxide, disodium hydrogen phosphate, dimethylsulfoxide (DMSO), potassium dihydrogen phosphate, dicyclohexylcarbodiimide (DCC), hydrochloric acid, dimethylformamide (DMF), deuterated DMSO, lauric acid, 4-(dimethylamino) pyridine (DMAP), potassium chloride, and propidium iodide were purchased from Sigma-Aldrich (St Quentin-Fallavier, France). RNAse A was obtained from Fisher Scientific (Illkirch, France). Deionized water was obtained from a Milli-Q plus system (Merck-Millipore, Darmstadt, Germany). Absolute ethanol, acetonitrile LC/MS grade, and methanol LC/MS grade were purchased from Biosolve (Dieuze, France). Methanol and dichloromethane (DCM) laboratory reagent grades were obtained from Fisher Chemical (Illkirch, France).

Decitabine was purchased from LC Laboratories^® (Woburn, MA, USA). Labrafac^® WL1349 (caprylic-capric acid triglycerides), Labrafil^® M1944CS (oleoyl macrogol-6 glycerides), Peceol^® (glycerol mono-oleates), and Transcutol^® HP (THP) (highly purified diethylene glycol monoethyl ether) were kindly provided by Gattefossé (Saint-Priest, France). Lipoïd^® S75-3 (soybean lecithin: 69% phosphatidylcholine and 10% phosphatidylethanolamine) and Kolliphor^® HS15 (mixture of free polyethylene glycol [PEG] 660 and PEG 660 hydroxystearate) were kindly supplied by Lipoïd^® and BASF, respectively (Ludwigshafen, Germany). Deionized water was obtained from a Milli-Q plus system (Merck-Millipore, Darmstadt, Germany). Sodium chloride and disodium hydrogen phosphate were purchased from Prolabo (Fontenay-Sous-Bois, France) and sucrose was purchased from Merck-Millipore. Sodium phosphate dibasic dodecahydrate, potassium dihydrogen phosphate, formic acid, ammonium acetate, Triton^® X-100, Tween^® 80, Span^® 80, and formic acid were obtained from Sigma-Aldrich (St Quentin-Fallavier, France). Captex^® 8000 (glyceryl tricaprylate) was a gift from Abitec Corp. (Saint-Quentin Fallavier, France).
Absolute ethanol, methanol ULC/MS grade, acetonitrile, and LC-MS grade water were purchased from Biosolve (Dieuze, France). Acetone was purchased from VWR (Fontenay-sous-Bois, France).