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I stat 1

Manufactured by Abbott
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Sourced in United States, Australia

The I-STAT 1 is a portable, handheld blood analysis system designed for point-of-care testing. The device is capable of performing a range of diagnostic tests on small volume blood samples, providing rapid results to support clinical decision-making.

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Lab products found in correlation

Bupivacaine, by Pfizer (2 mentions) Ret 2, by Physitemp (2 mentions) Coagucheck, by Roche (2 mentions) Precision xceed, by Abbott (1 mentions) Au2700 chemistry analyzer, by Beckman Coulter (1 mentions) Unicel dxh 800 coulter cellular analysis system, by Beckman Coulter (1 mentions) Cg8 test cartridges, by Abbott (1 mentions) Biosen c line, by EKF Diagnostics (1 mentions) Istat g3 cartridges, by Abbott (1 mentions) Bupivacaine, by GlaxoSmithKline (1 mentions) Paracetamol, by GlaxoSmithKline (1 mentions) Au480 chemistry analyzer, by Beckman Coulter (1 mentions) Cobas c501 chemistry analyzer, by Roche (1 mentions) Force fx 8c, by Medtronic (1 mentions) I stat cg8 cartridge, by Abbott (1 mentions) I stat, by Abbott (1 mentions)

22 protocols using i stat 1

1

Broiler Hen Blood Chemical Analysis

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After the hens were subjected to HS for 4 h (38 wk of age), 12 breeder hens from each treatment group were randomly selected for blood chemical analysis using an Abbott i-STAT 1 handheld blood gas analyzer (Abbott Point of Care Inc., IL) equipped with a CG8+ cartridge (Abaxis item number 600-9001). This CG8+ cartridge performed various parameters such as partial pressure of carbon dioxide (PCO2) and oxygen (PO2), pH, saturation of oxygen (sO2), concentration of bicarbonate ions (HCO3−), total concentration carbon dioxide (TCO2), concentration ionized calcium (iCa), sodium (Na), potassium (K), glucose (Glu), hematocrit (Hct), hemoglobin (Hgb), and base excess (BE). Blood from each breeder hen was collected and quickly placed in a lithium heparin tube that should be used for analysis within 3 min. One hundred μL of blood was dropped into the CG8+ cartridge, which was subsequently inserted into the Abbott i-STAT 1 handheld blood gas analyzer (Barrett et al., 2019 (link)).
Pasri P., Rakngam S., Gérard N., Mermillod P, & Khempaka S. (2023). Synthetic and phytogenic antioxidants improve productive performance, antioxidant activity, gene expression, and offspring quality in breeder hens subjected to heat stress. Poultry Science, 103(3), 103390.
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2

Apnea-Induced Cardiac Arrest Protocol

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After intracranial monitors had equilibrated to steady state (approximately 60 minutes), we discontinued propofol and collected a baseline arterial blood gas (ABG) sample (i-Stat 1, Abbott Point of Care, Inc.). We administered a rapid IV bolus of fentanyl (30mcg/kg) and vecuronium (10mg) to induce apnea, disconnected the ventilator and occluded the ETT. We recorded the total instrumentation from initial intramuscular sedation to ETT occlusion, and the time from ETT occlusion to cardiac arrest. We defined cardiac arrest as either degeneration to ventricular fibrillation or pulseless electrical activity below an arterial systolic pressure of 40mmHg.
Elmer J., Flickinger K.L., Anderson M.W., Koller A., Sundermann M., Dezfulian C., Okonkwo D.O., Shutter L.A., Salcido D., Callaway C.W, & Menegazzi J.J. (2018). Effect of neuromonitor-guided titrated care on brain tissue hypoxia after opioid overdose cardiac arrest. Resuscitation, 129, 121-126.
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3

Quantifying Hemolysis in Blood Samples

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Free hemoglobin was measured by photometry. Hematocrit, hemoglobin, pH and glucose were analyzed using a mobile blood gas analysis system (i-STAT 1, Abbott GmbH, Wiesbaden, Germany). For a standardized comparison of hemolysis the normalized milligram index of hemolysis (mgNIH) was calculated (14 (link)). The index is defined as free hemoglobin in mg released from 100 L of circulating blood (14 (link)).
Zieger B., Schneider D., Brixius S.J., Scherer C., Buchwald A., Trummer G., Czerny M., Beyersdorf F., Busch H.J., Benk C, & Pooth J.S. (2023). Development of an in-vitro model for extracorporeal blood pumps to study the effects of artificial pulsatility on human blood. Frontiers in Medicine, 10, 1237002.
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4

Blood Analysis after Tracheal Extubation

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Arterial blood samples of approximately 200 µL taken after each procedure or at time points after tracheal extubation were used for haematological analysis, blood gas analysis and lactate measurements. The i-STAT 1 portable analyser (Abbott Point of Care, Princeton, New Jersey, USA) and the test cartridges (CG4+; Abbott Point of Care) were used with 100 µL samples for gas analysis and lactate measurements, while 50 µL of each blood sample was analysed using the pocH-100iV Diff haematology analyser (Sysmex). Haematocrit was measured with glass capillaries.
Hashimoto R., Kohno M., Oiwa K., Onozawa H., Watanabe M., Horinouchi H., Sakai H., Kobayashi K, & Iwazaki M. (2020). Immediate effects of systemic administration of normal and high O2-affinity haemoglobin vesicles as a transfusion alternative in a rat pneumonectomy model. BMJ Open Respiratory Research, 7(1), e000476.
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5

Cardiovascular Monitoring in Anesthetized Rats

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Rats were anaesthetised with isoflurane (5% induction, 1.75–2.5% maintenance) in 50:50% N2:O2. Incision sites were subcutaneously injected with 2 mg/kg 0.05% Bupivacaine (Pfizer, Sydney, Australia). Core body temperature was regulated via a thermocoupled rectal probe (RET-2, Physitemp Instruments Inc, Clifton, NJ, USA) and heat mat.
A catheter was inserted into the saphenous branch of the femoral artery and was used to obtain mean arterial blood pressure and heart rate. Blood samples (0.1 mL) were taken from the catheter for arterial blood gas and pH measurements using a fast blood analyser (i-STAT 1; Abbott, Australia). A similar catheter was placed into the femoral vein for infusion of acetazolamide. Oxygen saturation and respiration were monitored throughout procedures.
Bothwell S.W., Omileke D., Patabendige A, & Spratt N.J. (2021). CSF Secretion Is Not Altered by NKCC1 Nor TRPV4 Antagonism in Healthy Rats. Brain Sciences, 11(9), 1117.
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6

Myocardial Ischemia Biomarker Analysis

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During the experiment, blood samples were taken at 4 different time points (Table 1). The 0-sample was collected at baseline after induction of anesthesia; the 1-sample 8 hours later, before ischemia; the 2-sample after the release of LAD ligature; and the 3-sample at the end of the experiment. Levels of interleukin-6 (IL-6) (P600B; R&D Systems, Minneapolis, MN) and cardiac troponin I (TnI) (MBS2509024; MyBiosource, San Diego, CA) were analyzed using enzyme-linked immunosorbent assay. Arterial blood gas analysis, hemoglobin, and blood cardiac troponin T (TnT) values were controlled using a point-of-care blood analyzer (i-STAT 1; Abbott Laboratories, Princeton, NJ). At the end of the experiment, the ascending aorta was clamped, the ligature on the LAD was tightened, and an injection of methylene blue to the base of the aorta was given to stain myocardium. Myocardial tissue samples from the site of ischemia, border of ischemia, and healthy myocardium were harvested and frozen after termination of the experiment.
Deomic Niittynen S., Liikamaa L., Jalkanen J., Jalkanen S., Savunen T., Gunn J., Anttila V., Virtanen L., Taimen P., Hollmén M., Pan E., Saura E, & Malmberg M. (2021). Intravenous Interferon-β1a for the Treatment of Ischemia-Reperfusion Injury in Acute Myocardial Infarct in Pigs. The heart surgery forum, 24(2).
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7

Measuring Blood Biomarkers for Hydration

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Beta-hydroxybutyrate concentrations were analyzed in whole blood samples using an
automatic analyzer (Precision Xceed, Abbott Lab.); hematocrit (Hct), Hb and BE were
measured using an automatic gas analyzer (i-STAT 1, Abbott Lab.). Changes in relative
plasma volume (rPV) were calculated from Hb and Hct, using accepted formulas [10 (link)].
TSUKANO K., KATO S., SARASHINA S., ABE I., AJITO T., OHTSUKA H, & SUZUKI K. (2017). Effect of acetate Ringer’s solution with or without 5% dextrose administered intravenously to diarrheic calves. The Journal of Veterinary Medical Science, 79(4), 795-800.
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8

Continuous Blood Composition Monitoring

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Supplementary Tables 1 and 2 online illustrate additional blood composition analyses. To assess the consistency of continuous CDI blood monitoring, blood samples were collected from the reservoir for analysis every 15 min. This included portable clinical analyses (sodium, potassium, chloride, CO2, anion gap, ionized calcium, glucose, urea nitrogen, creatinine, hematocrit and hemoglobin; I-stat 1, Abbott) and separate conventional clinical laboratory analyses of complete blood count and blood chemistry obtained after EPCC.
Shariff M., Dobariya A., Albaghdadi O., Awkal J., Moussa H., Reyes G., Syed M., Hart R., Longfellow C., Douglass D., El Ahmadieh T.Y., Good L.B., Jakkamsetti V., Kathote G., Angulo G., Ma Q., Brown R., Dunbar M., Shelton J.M., Evers B.M., Patnaik S., Hoffmann U., Hackmann A.E., Mickey B., Peltz M., Jessen M.E, & Pascual J.M. (2023). Maintenance of pig brain function under extracorporeal pulsatile circulatory control (EPCC). Scientific Reports, 13, 13942.
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9

Comprehensive Hemodynamic Analysis During Infarct

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At each haemodynamic reading, blood samples were simultaneously obtained via the peripheral and pulmonary arterial catheters for blood gas analysis with lactate (Handheld Blood Analyzer iSTAT-1, Abbott Point of Care Inc., Princeton, NJ, USA). Blood samples were also taken to determine concentration of haemoglobin (UniCel DxH 800 Coulter Cellular Analysis System, Beckman Coulter, Inc., Brea, CA, USA), cardiac troponin I by immuno-assay, ethanol and key electrolytes (Na+, K+, Cl-, Ca2+) (AU2700 chemistry analyzer and DXI600 Access Immuno-assay system, Beckman Coulter) before infarct induction and prior to sacrifice.
Rienzo M., Imbault J., El Boustani Y., Beurton A., Carlos Sampedrano C., Pasdois P., Pernot M., Bernus O., Haïssaguerre M., Couffinhal T, & Ouattara A. (2020). A total closed chest sheep model of cardiogenic shock by percutaneous intracoronary ethanol injection. Scientific Reports, 10, 12417.
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10

Whole Blood Analysis: Hb and SvO2

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An I-STAT analyser (I-STAT 1, Abbott Point of Care, Princeton, NJ, USA) was used to analyse the whole blood sample for haemoglobin and forearm venous oxygen saturation ( SvO2 ) using CG8+ test cartridges (Abbott Point of Care). All blood samples were analysed in duplicate, and averaged.
Tucker W.J., Rosenberry R., Trojacek D., Chamseddine H.H., Arena-Marshall C.A., Zhu Y., Wang J., Kellawan J.M., Haykowsky M.J., Tian F, & Nelson M.D. (2019). Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near-infrared diffuse correlation spectroscopy. The Journal of physiology, 597(11), 2887-2901.
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