Piceatannol

Manufactured by Santa Cruz Biotechnology

Sourced in Germany

Piceatannol is a natural polyphenol compound primarily extracted from the bark of the passion flower (Passiflora incarnata). It functions as a selective inhibitor of the Syk protein tyrosine kinase, an enzyme involved in various cellular processes.

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5 protocols using piceatannol

Antimicrobial Screening of Natural Compounds

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The bacterial strains used in this study are highlighted in Table 1. Chemicals used in this study include tomatidine hydrochloride (Merck KGaA, Darmstadt, Germany), oligomycin A (Santa Cruz Biotechnology, Dallas, TX, USA), N,N′-Dicyclohexylcarbodiimide (Merck KGaA, Darmstadt, Germany), piceatannol (Santa Cruz Biotechnology, Dallas, TX, USA) and resveratrol (Santa Cruz Biotechnology, Dallas, TX, USA).
All bacterial strains and the two Candida albicans isolates were routinely cultured at 37 °C in tryptic soy broth (TSB) or on tryptic soy agar (TSA), whereas Aspergillus niger was cultured in nutrient broth (NB).

Vestergaard M., Roshanak S, & Ingmer H. (2021). Targeting the ATP Synthase in Staphylococcus aureus Small Colony Variants, Streptococcus pyogenes and Pathogenic Fungi. Antibiotics, 10(4), 376.

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Evaluating Syk Inhibitors for Malaria Treatment

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All Syk inhibitors were solubilized initially at 10 mM concentration in anhydrous DMSO (Dimethyl sulfoxide) and then serially diluted into anhydrous DMSO prior to the addition to malaria cultures. Untreated cultures were run in parallel with the same final concentration 0.01% (v/v) of DMSO as the drug-treated cultures. Cultures at the ring stage of P. falciparum were treated at 12 h post infection, from 3 to 24 h, with the indicated concentrations of dihydroartemisinin (DHA), artesunate (AS), or artemether (ATH) combined with the desired concentration of one of the following Syk inhibitors: P505-15 (Selleckchem); R406 (Calbiochem, Darmstadt, Germany), entospletinib (Selleckchem), Syk inhibitor II (henceforth abbreviated as SYK II), piceatannol, or imatinib (Santa Cruz Biotechnology).

Tsamesidis I., Reybier K., Marchetti G., Pau M.C., Virdis P., Fozza C., Nepveu F., Low P.S., Turrini F.M, & Pantaleo A. (2020). Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress in Plasmodium falciparum-Parasitized Erythrocytes. Antioxidants, 9(8), 753.

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Pharmacological Inhibitors of Cell Signaling

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Chemical inhibitors used were cytochalasin D (5 μM), amlexanox (200 μM), and wortmannin (100 nM) (all 3 from Sigma-Aldrich); UO126 (5 μM), rapamycin (10 nM), and Torin1 (10 nM) (all from Cell Signaling Technology); GDC-0941 (5 μM) and SB216763 (10 μM) (both from APExBIO); triciribine (10 μM; Calbiochem/Thermo); Akt inhibitor VIII (10 μM; Merck/Millipore); cyclosporine (10 and 50 ng/ml) and EGTA (2 mM; both from Sigma); piceatannol (25 μM; Santa Cruz Biotechnology); and VPS34-IN1 (1 μM) and SAR405 (1 μM) (both from the Division of Signal Transduction Therapy Unit, University of Dundee).

Pittini Á., Martínez-Acosta Y.E., Casaravilla C., Seoane P.I., Rückerl D., Quijano C., Allen J.E, & Díaz Á. (2019). Particles from the Echinococcus granulosus Laminated Layer Inhibit CD40 Upregulation in Dendritic Cells by Interfering with Akt Activation. Infection and Immunity, 87(12), e00641-19.

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Chemical Inhibitors in Cell Signaling

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The following chemical inhibitors were used: Z-YVAD-FMK (10 μM; Calbiochem/Merck), wortmannin (1 μM; Sigma), GDC-0941 (5 μM; Calbiochem/Thermo), piceatannol (25 μM; Santa Cruz Biotechnology), cytochalasin D (5 μM; Sigma-Aldrich), and Vps34-IN1 (1 μM) and SAR405 (1 μM) (both from the Division of Signal Transduction Therapy Unit, University of Dundee, Dundee, Scotland).

Casaravilla C., Pittini Á., Rückerl D., Allen J.E, & Díaz Á. (2020). Activation of the NLRP3 Inflammasome by Particles from the Echinococcus granulosus Laminated Layer. Infection and Immunity, 88(9), e00190-20.

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Quantitative Analysis of Polyphenol Standards

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Non-labeled kaempferol, resveratrol, quercetin, piceatannol, apigenin, luteolin, naringenin, curcumin, and ferulic acid were obtained from Santa Cruz Biotechnology, Inc. All these compounds were checked in the Mass Spectrometry & Chromatography Service of the University of Córdoba and contamination with 4HB, vanillic or protocatechuic acid was not detected at levels higher than 0.01% of solid material. PABA, 4HB, vanillin, nicotinamide (NAM), 4-hydroxyphenylacetic acid and p-cresol were purchased from Sigma-Aldrich. ¹³C-kaempferol was obtained from IsoLife and D₆-curcumin and D₃-ferulic acid were purchased from SynInnova. ¹³C₁₂-curcumin was synthesized from ¹³C₆-vanillin (Cambridge Isotopes Laboratories Inc) following a published procedure [16 (link)]. Standards of Q₄, Q₆, Q₉ and Q₁₀ were purchased from Sigma-Aldrich. Dipropoxy-Q₁₀ was synthesized essentially as described by Edlund [17 (link)] for diethoxy-Q₁₀, except 1-propanol was substituted for ethanol while maintaining the other reagents and conditions.

Fernández-del-Río L., Nag A., Casado E.G., Ariza J., Awad A.M., Joseph A.I., Kwon O., Verdin E., de Cabo R., Schneider C., Torres J.Z., Burón M.I., Clarke C.F, & Villalba J.M. (2017). Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor. Free radical biology & medicine, 110, 176-187.

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