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Mel 80 excimer laser

Manufactured by Zeiss
Sourced in Germany

The Mel 80 excimer laser is a medical device designed for ophthalmic procedures. It utilizes ultraviolet laser light to precisely reshape the cornea, a process known as photorefractive keratectomy (PRK) or laser-assisted in-situ keratomileusis (LASIK). The Mel 80 excimer laser operates at a wavelength of 193 nanometers and is capable of delivering controlled pulses of laser energy to the corneal surface.

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11 protocols using mel 80 excimer laser

1

Femtosecond-Assisted Customized LASIK

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First, corneal flaps, with a super-hinge length of 4.0 mm, located at 12 o’clock, were created using the VisuMax femtosecond laser system. Laser settings were similar to those of SMILE. Once the flap scanning was finished, it was manually lifted using a spatula and gently positioned in the upper cornea. Subsequently, stromal ablation was performed using the MEL 80 excimer laser (Carl Zeiss Meditec AG, Germany) system, with parameters programmed as 500 Hz repetition rate. The diameter and thickness of the flap were 7.5 mm and 110 μm, respectively. The optical zone varied from 5.75 to 6.25 due to the corneal thickness and refractive errors. Bandage soft contact lenses were placed to protect each eye for 1 day and removed at the following day. The same surgeon completed all the procedures uneventfully (XZ).
The postoperative medication regimen included the administration of topical levofloxacin (Santen Pharmaceutical, Osaka, Japan) four times per day for 1 week and then 0.1% fluorometholone eye drops (Santen Pharmaceutical, Osaka, Japan) from eight times to one time per day over 24 days in a sequential decreasing order. Lacrimal substitutes were also used four times per day from 1 to 3 months, as required.
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2

Corneal Refractive Surgery Protocols

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All surgeries were performed under local anesthesia by one surgeon (Hao Zhou) with patients undergoing either SMILE or FS-LASIK.
SMILE was performed using the VisuMax femtosecond laser system (Carl Zeiss Meditec) with a repetition rate of 500 kHz, pulse energy of 185–190 nJ, intended cap thickness of 100–120 μm, cap diameter of 7.5 mm, lenticule diameter of 6.1 to 6.6 mm (depending on the refractive error), and a 90°-angle side cut with a circumferential length of 2.1 mm at the superior position.
FS-LASIK was performed with the VisuMax system for flap creation followed by Mel 80 excimer laser (Carl Zeiss Meditec) for stromal ablation, with an intended flap thickness of 95 μm and pulse energy of 185 nJ. The hinge was located at the superior position.
A standard postoperative topical steroid (Fluorometholone 0.1%) was tapered over 30 days; topical antibiotic (Tobramycin 0.003%) QID for 7 days, and unpreserved ocular lubricant 4 times a day was prescribed for a month.
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3

Corneal Refractive Surgery Techniques

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SMILE was performed using a 500 kHz VisuMax femtosecond laser system (Carl Zeiss Meditec AG, Jena, Germany) in expert mode at the following settings for all the eyes: pulse energy of 130 nJ, corneal cap thickness of 100 μm, and optical zone diameter of 6.2–6.8 mm (depending on the preoperative corneal thickness and the refractive error to be corrected). The side cuts were set to 90° (12-o'clock position) with 2.0-mm circumferential width at the superior position. The technical procedure was conducted as previously described (11 (link)).
FS-LASIK was performed using a 500 kHz VisuMax femtosecond laser (Carl Zeiss Meditec AG, Jena, Germany) for flap creation and a 250 Hz MEL-80 excimer laser (Carl Zeiss Meditec AG, Jena, Germany) for stromal ablation at the following settings for all the eyes: pulse energy of 185 nJ, flap diameter of 8.0 mm, flap thickness of 90 μm, hinge length of 4.0 mm, and optical zone diameter of 6.2–6.8 mm. In all patients, bandage soft contact lenses (ACUVE OASYS, Inc., FL, USA) were applied for 1 day after surgery.
All surgeries were performed by the same skilled surgeon in both procedures (XZ).
Both groups received the same postoperative topical medications: levofloxacin 4 times per day for 7 days; 0.1% fluorometholone 8 times per day tapered to 1 time per day over 24 days, and artificial tears 4 times per day for 1 month.
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4

Femtosecond Laser-Assisted SMILE and LASIK Procedures

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SMILE was performed using VisuMax femtosecond laser system (Carl Zeiss Meditec, Jena, Germany) with a repetition rate of 500 kHz and a pulse energy of 130 nJ. Lenticule diameter was set to 6 mm. The intended corneal cap thickness was set to 100–120 μm with a diameter of 7.5 mm. The procedure is described previously.10 (link)
In the FS-LASIK procedures, the same femtosecond laser system was used for flap creation with a pulse energy of 185 nJ, followed by a MEL 80 excimer laser (Carl Zeiss Meditec, Oberkochen, Germany) for stromal ablation with a repetition rate of 250 Hz and a pulse energy of 1.00±0.15 mJ. The intended flap thickness was set to 100 μm with a diameter of 8 mm. The hinges were located at a superior 12 o’clock with a length of 4.0 mm.
All surgeries were performed by an experienced surgeon (XTZ). Prior to surgery, 0.5% topical levofloxacin (Cravit; Santen, Osaka, Japan) was applied four to six times daily for 3 days. A bandage soft contact lens was applied for 1 day after FS-LASIK. After both procedures, 0.5% topical levofloxacin, 0.1% fluorometholone solution and non-preserved artificial tears (carboxymethylcellulose sodium eye drops; Allergan, Irvine, California, USA) were applied.
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5

Femtosecond Laser-Assisted LASIK Protocol

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Before surgery, patients were instructed to use antibiotic drops (levofloxacin 0.5%; Santen, Ishikawa, Japan) four times daily for 3 day. VisuMax femtosecond laser (Carl Zeiss Meditec, Inc., Jena, Germany) was the laser platform of the choice to create LASIK flap in all patients. A single surgeon (X.T.Z.) carried out laser ablation using MEL 80 excimer laser (Carl Zeiss Meditec, Inc.) after flap lifting. The optical zone was set at 6.50 mm in 20 eyes and 6.75 mm in 4 eyes, with a transition zone of 1 mm (total ablation zone of 8.5 or 8.75 mm). Then the flap was repositioned using standard techniques. A bandage contact lens was placed on the surgically treated eye for 1 day. Immediately after surgery, a combination of antibiotics (levofloxacin 0.5%; Santen) and steroids (fluorometholone 0.1%; Santen) drops was applied. levofloxacin 0.5% was applied four times daily in the first week, and fluorometholone 0.1% was used six times daily in the first postoperative 3 days and were gradually tapered every week to once a day. In addition, nonpreserved artificial tears (sodium carboxymethyl cellulose 0.5%; Allergan, Irvine, CA) were applied for 6 months.
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6

Comparison of LASIK and SMILE Procedures

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Surgical techniques were the same for all patients of one group. In the LASIK group, a hinged corneal flap with a thickness of 110 μm and a diameter of 8.4 to 8.5 mm was created with the VisuMax® femtosecond laser (Carl Zeiss Meditec, Jena, Germany). The Mel 80 excimer laser (Carl Zeiss Meditec, Jena, Germany) with iris recognition software was used for photoablation within a 6.5–6.75 treatment area. In contrast to LASIK, SMILE is a flapless procedure. Before starting the surgery, the patient was asked to fixate on a blinking target. When adequate centration was achieved, the eye was fixated using a curved suction contact glass. A lenticule was produced using the VisuMax® femtosecond laser system (Carl Zeiss Meditec, Jena, Germany) that was set at an intended cap thickness of 120 μm and optical zone of 6.25–6.5 mm. The lenticule was then grasped and removed through a small incision. All surgeries were uneventful and no severe postoperative complications occurred.
Postoperatively, patients in both groups received polymyxin/ neomycin/ dexamethasone eye-drops (Isopto-Max, Alcon) 4 times daily for 5 days. For 4 weeks, artificial tear supplements were prescribed, starting hourly the first week and reduced to weekly as needed.
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7

Refractive Laser Procedures: SMILE and LASEK

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All the procedures were performed by one surgeon (XTZ). All the target diopters were set to 0D. SMILE procedures were performed using a VisuMax femtosecond laser system (Carl Zeiss Meditec, Jena, Germany) with a pulse energy of 130 nJ. The cap was set to 120-μm thickness and 7.5-mm diameter. The side cut was set to 2 mm. The superior surface and the inferior surface of the lenticule were separated from the anterior stroma. The lenticule was then extracted through the side cut. LASEK was performed using a Mel 80 excimer laser (Carl Zeiss Meditec, Jena, Germany) system. Corneal epithelial trephines (Model 52503B; 66 Vision Tech Co., Ltd., Suzhou, China) with an inner diameter of 8.5 mm and a 20% ethanol-aqueous solution were employed to create an epithelial flap. The excimer laser with a repetition rate of 250 kHz and pulse energy of 150 nJ was used to ablate the corneal stroma. The epithelial flap was repositioned after the excimer laser treatment (9 (link)).
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8

Comparison of LASEK and Epi-LASIK Procedures

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LASEK treatments began with 20% alcohol-assisted epithelial removal, followed by standard excimer laser ablation with a Mel-80 excimer laser (software version: 3.6, Carl Zeiss Meditec AG; tissue-saving ablation profiles; standard nomogram). As the patient focused on a fixation light, the excimer laser energy was delivered to the cornea centred on the optical axis. The epithelium was repositioned after laser ablation, and a bandage contact lens was applied.
During Epi-LASIK, the rotational Epi-LASIK microkeratome (KM-5000D, Wuxi Kangming Medical Device Corp, Wuxi, China) was used to create the epithelial sheet.9 The remainder of the procedure closely mirrored the LASEK procedure.
Mitomycin C was not used in either LASEK or Epi-LASIK cases. Bandage contact lenses were removed when epithelialisation was complete (usually between postoperative days 3 and 7).
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9

Corneal Refractive Surgery Techniques

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The surgeries were all performed by the same surgeon (XZ). In the SMILE procedure, a 500 kHz VisuMax femtosecond laser system (Carl Zeiss Meditec, Jena, Germany) was used with pulse energy of 130 nJ. The lenticule diameter was set between 5.5 mm and 6.70 mm; the cap diameter was set to 7.5 mm at a 100 μm depth. A 90° single side cut with a length of 2.0 mm was created during the procedure. In the FS-LASIK group, the same femtosecond laser system was used for flap creation, followed by a Mel 80 excimer laser (Carl Zeiss Meditec) for stroma ablation, with a pulse energy of 185 nJ. The flaps had diameters of 8.5 mm and a thickness of 100 μm, with standard 90° hinges.
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10

SMILE and FS-LASIK Procedures Compared

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SMILE was performed using the VisuMax femtosecond laser system (Carl Zeiss Meditec) with a repetition rate of 500 kHz, pulse energy of 185-190 nJ, intended cap thickness of 100-120 mm, cap diameter of 7.5 mm, lenticule diameter of 6.1 to 6.6 mm (depending on the refractive error), and a 90 -angle side cut with a circumferential length of 2.1 mm at the superior position.
FS-LASIK was performed with the VisuMax system for flap creation followed by Mel 80 excimer laser (Carl Zeiss Meditec) for stromal ablation, with an intended flap thickness of 95 mm, optical zone size of 5.75-6.50 mm and pulse energy of 185 nJ. The hinge was located at the superior position. All procedures were performed by one surgeon experienced in both types of procedures. (H.Z).
A standard postoperative topical steroid (Flurometholone 0.1%) tapered over 30 days (or longer if deemed necessary), and topical antibiotic (Tobramycin 0.003%) QID for 7 days was given.
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