Anti ifnar2 antibody clone mmhar 2

Manufactured by PBL Assay Science

The Anti-IFNAR2 antibody (clone MMHAR-2) is a laboratory reagent used for research purposes. It is a monoclonal antibody that specifically binds to the IFNAR2 subunit of the type I interferon receptor.

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Lab products found in correlation

Anti pd 1 clone eh12.2h7, by BioLegend (1 mentions)

Close spelling variants of this product

MMHAR-2 Anti-IFNAR2

2 protocols using anti ifnar2 antibody clone mmhar 2

Immune Checkpoint Blockade Modulation

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PBMCs were stimulated with PFA-fixed E. coli in the presence of anti–PD-1 (clone EH12.2H7; BioLegend), anti–LAG-3 (clone 17B4; Abcam), anti-IFNAR2 antibody (clone MMHAR-2; PBL Assay Science), or purified anti–IL-10R antibody (clone 3F9; BioLegend) at 10 μg/ml. Mouse IgG2a κ and rat IgG2a κ isotype control antibodies were used as controls.

Tang X., Zhang S., Peng Q., Ling L., Shi H., Liu Y., Cheng L., Xu L., Cheng L., Chakrabarti L.A., Chen Z., Wang H, & Zhang Z. (2020). Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection. Science Advances, 6(8), eaaz0374.

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Anti-IFNAR2 Antibody Effects on IFN-β Signaling

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Indicated cell lines were seeded 24 h prior to treatment with 1 µg/ml anti-IFNAR2 antibody (clone MMHAR-2, PBL Assay Science). After 24 h, cells were analyzed using Western Blotting. As positive control, cells were pre-treated with 1 µg/ml anti-IFNAR2 antibody for 1 h, followed by 0.05 ng/ml recombinant human IFN-β for 1 h.

Karlowitz R., Stanifer M.L., Roedig J., Andrieux G., Bojkova D., Bechtel M., Smith S., Kowald L., Schubert R., Boerries M., Cinatl J J.r., Boulant S, & van Wijk S.J. (2022). USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING. Cell Death & Disease, 13(8), 684.

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