Ab chminaca

Manufactured by Cayman Chemical

Sourced in United States

AB-CHMINACA is a synthetic cannabinoid compound used in laboratory research. It is a chemical standard for analytical and reference purposes. The core function of AB-CHMINACA is to serve as a reference material for analytical testing and research applications.

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Lab products found in correlation

4 protocols using ab chminaca

Synthesis of Synthetic Cannabinoids

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All reagents and solvents were
high performance liquid chromatography- or analytical-grade to get
high purity compared to MS solvent. Diphenylamine (DPA), dichloromethane
(CH₂Cl₂), water (H₂O), and methanol
(CH₃OH) were obtained from Merck (AnalaR, Merck BDH, Poole,
UK). Hydrochloric acid (HCl) and ammonium hydroxide (NH₄OH 25%) were purchased from Fluka (Fluka, Buchs, Switzerland). The
SC standards of AB-FUBINACA, AB-CHMINACA, and XLR-11 were adopted
from Cayman Chemical Company (Cayman Chemical, Ann Arbor, Michigan).

AL-Eitan L.N., Asa’ad A.S., Battah A.H, & Aljamal H.A. (2020). Application of Gas Chromatography–Mass Spectrometry for the Identification and Quantitation of Three Common Synthetic Cannabinoids in Seized Materials from the Jordanian Market. ACS Omega, 5(8), 4172-4180.

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Preparation and Administration of AB-CHMINACA

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A solid form of AB-CHMINACA was purchased from Cayman Chemicals, USA. The substance was dissolved in absolute ethanol followed by dilution in normal saline (ethanol: saline 1:9) immediately before injection. Human diagnostic kits for ALT and AST were from Roche Diagnostics USA.

Mohammad S.A., Mousa R.E., Gebril S.M., Masoud K.M, & Radwan R.A. (2023). Toxic effects of AB-CHMINACA on liver and kidney and detection of its blood level in adult male mice. Forensic Toxicology, 42(1), 7-17.

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Novel Psychoactive Substance Analysis

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FDU-PB-22 (1), FUB-PB-22, AB-CHMINACA, 5-fluoro-AMB, AM-2201 indazole analog (THJ-2201), NNEI indazole analog (MN-18), 4-methylbuphedrone, DL-4662, and 3,4-EDMA were purchased from Cayman Chemical (Ann Arbor, MI, USA); 2-methylpropyl N-(naphthalen-1-yl) carbamate (5) and diphenidine from Otava Ltd. (Toronto, Canada) and Tocris Bioscience (Bristol, UK), respectively. All other common chemicals and solvents were of analytical reagent grade or high-performance liquid chromatography (HPLC) grade. As solvents for nuclear magnetic resonance (NMR) analysis, chloroform-d₃ (99.96 %), methanol-d₄ (99.96 %), methanol-d₃ (99 %), pyridine-d₅ (99.96 %), and dimethyl sulfoxide (DMSO)-d₆ (99.96 %) were purchased from the ISOTEC division of Sigma-Aldrich (St. Louis, MO, USA).

Uchiyama N., Shimokawa Y., Kikura-Hanajiri R., Demizu Y., Goda Y, & Hakamatsuka T. (2015). A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products. Forensic Toxicology, 33(2), 244-259.

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Characterization of AB-CHMINACA Metabolism

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The standard for AB-CHMINACA was obtained from Cayman Chemical Company (Ann Arbor, Michigan, USA) in neat powder. The standards for theophylline, benzamide, tramadol, 4-nitrophenol, 2,6-uridine-diphosphate glucuronic acid (UDPGA), alamethicin and NADPH (all neat, purity >99%) were obtained from Sigma-Aldrich (Diegem, Belgium).
Pooled human liver microsomes (HLMs; mix gender, n=200) were purchased from Tebu-bio (Boechout, Belgium). Baculovirus-insect cell microsomes containing expressed human CYP enzyme (CYP1A2, 2B6, 2C9, 2C19, 2D6, 2E1 or 3A4) co-expressed with human CYP oxidoreductase and human cytochrome b5 were purchased from BD Biosciences (Erembodegem, Belgium) and Tebu-Bio. Ultrapure water was prepared using a Purelab flex water system from Elga (Tienen, Belgium). Methanol, acetonitrile and formic acid were purchased from Merck (Darmstadt, Germany). All organic solvents were HPLC grade or higher.

Erratico C., Negreira N., Norouzizadeh H., Covaci A., Neels H., Maudens K, & van Nuijs A.L. (2015). In vitro and in vivo human metabolism of the synthetic cannabinoid AB-CHMINACA. Drug testing and analysis, 7(10).

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