The Secure-C CDA manufactured by Globus Medical Inc. (Audubon, PA, USA), Mobi-C, manufactured by Zimmer Biomet (Warsaw, IN, USA), Prodisc C manufactured by Centinel Spine (West Chester, PA, USA), and Prestige LP manufactured by Medtronic Sofamor Danek (Memphis, TN, USA) were used in the study for single-level surgery [15 (link)]. Ultra-high-molecular-weight polyethylene (UHMWPE) material is used in the first three devices; however, in the Prestige LP, only metal components are used.
Prestige lp
Manufactured by Medtronic
Sourced in United States
The Prestige LP is a laboratory equipment product manufactured by Medtronic. It serves as a centrifuge, enabling the separation of different components within a liquid sample through the application of centrifugal force.
Automatically generated - may contain errors
Lab products found in correlation
6 protocols using prestige lp
1
Cervical Disc Arthroplasty Devices Comparison
2
Artificial Cervical Disc Replacement Protocol
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Following induction of general anesthesia, the patient was placed in a supine position with a cushion under the neck to maintain the normal lordosis of the cervical spine. A classical Robinson-Smith approach was adopted, and a transverse incision was made on the right side of the neck. The soft tissue was pulled to both sides and the targeted disc tissue and longitudinal ligament were removed. Surgery was performed initially on the most severely damaged level to avoid the potential risk of spinal cord injury due to the operation. The bilateral foramen and uncovertebral joints were also decompressed completely. The endplates were burred to expose the cortical endplate surface, followed by placement of a Prestige-LP artificial cervical disc (Medtronic Sofamor Danek, Memphis, TN) and use of the Zero-P system (Synthes, Oberdorf, Switzerland). The intervertebral space was filled with an appropriate provisional implant. TDR was performed before ACDF, whereas, for continuous 2-level TDR, the cephalic level underwent TDR first, because tapping during the implantation of a Prestige-LP may risk prosthesis migration and screw loosening [7 (link)]. Generally, surgery was performed so as not to increase the degree of spinal cord compression and not to affect the instability of the implanted discs.
3
Single-Level Cervical Disc Replacement Outcomes
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This was an observational, single-center study. Patients who underwent single-level cervical disc replacement using the PRESTIGE LP (Medtronic Sofamor Danek, Memphis, Tennessee, USA) from 2008 to 2017 were included in this study. All surgeries were performed by the same senior surgeon with the same surgical technique. The inclusion criteria were as follows: 1) 18–65 years old; 2) single-level cervical degenerative disc disease causing symptomatic radiculopathy or myelopathy between C3 and C7; and 3) failure of conservative treatment for at least 12 weeks. The exclusion criteria were as follows: 1) instability, irreducible kyphosis, or severe degeneration at the index level; and 2) prior cervical spine surgery. In total, 132 patients with at least 24 months follow-up were enrolled in this study.
4
Anterior Cervical Decompression and Fusion Procedures
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All the operations were conducted under the condition of general anesthesia in laminar flow operating room and conducted via a same senior surgeon. The patient underwent the standard Smith-Robinson anterior approach that exposed proper levels of symptomatic cervical spine, followed by a proper neurological structures decompression and complete discectomy. In group ACDF, the patients were fused with an anterior titanium structure (Zero-P device) and an allograft structure. And in group CDA, in accordance with intraoperative fluoroscopy guidance, the Prestige LP (Medtronic, Memphis, TN) artificial disc was implanted in the patients in this series. Afterward, the closed drainage catheter was placed, and wound of each patient was sealed layer by layer.
5
Multicenter Cervical Disc Replacement Study
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The FDA granted final approval of an IDE application (G050202) for this study in January 2006, and surgeries occurred between June 2006 and November 2007 (clinical trial registration no.: NCT00637156 [clinicaltrials. gov]). The study protocol and informed consent form were reviewed by independent IRBs at each investigational site (30 sites) and received IRB approval before the study began (Appendix). The prospective, randomized, multicenter, controlled study was designed to assess the safety and effectiveness of the investigational treatment (2-level Prestige LP artificial cervical disc replacement) compared with the control treatment (2-level ACDF procedure involving a cortical ring allograft and the Atlantis Cervical Plate System, Medtronic, Inc.) in patients with intractable radiculopathy and/or myelopathy at 2 adjacent levels of the cervical spine. Blinding of patients and surgeon investigators was not feasible or considered appropriate beyond the screening and informed consent process. Informed consent was obtained from all patients. The specific methods and procedures for the clinical trial have been described in detail elsewhere 10 and are similar to those reported for the single-level study, 9 but are summarized here.
6
Anterior Cervical Spine Procedure Protocol
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All operations were performed by the same senior spine surgeon. The patient was placed with the neck in a neutral position after general anesthesia. A standard right-side incision was performed along the skin crease to access the anterior cervical spine. Discectomy and decompression were performed using an anterior approach. The more severe degenerative segment should be decompressed primarily. CDA procedures were performed using a proper size Prestige-LP (Medtronic Sofamor Danek, Memphis, TN). For ACDF procedures, the Zero-P (Synthes, Oberdorf, Switzerland) implants packed with β-tricalcium phosphate or local excised bone were inserted into the well-prepared intervertebral space. All prostheses were placed under fluoroscopic guidance. After surgery, all patients were instructed to perform neck function training within the first 3 weeks and immobilized with a collar for 4 to 12 weeks.
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