Macular cube

Manufactured by Zeiss

The Macular Cube is a specialized optical device used for diagnostic imaging of the macula, the central part of the retina. It provides high-resolution, three-dimensional visualization of the macular structure. The Macular Cube employs advanced imaging technology to capture detailed information about the layers and features of the macula, which is essential for the assessment and management of various macular disorders.

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Lab products found in correlation

Cirrus hd oct, by Zeiss (2 mentions) Optic disc cube, by Zeiss (1 mentions)

2 protocols using macular cube

Quantifying Retinal Nerve Changes After Surgery

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Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) was used to acquire one macular (Macular Cube 200 × 200 protocol) and one optic disc (Optic Disc Cube 200 × 200 protocol) scan in each qualifying eye, after pupil dilation with 1% tropicamide and 2.5% phenylephrine. The ganglion cell analysis (GCA) algorithm used to process these data from 6.0 software version of Cirrus OCT; the algorithm detects and measures the thickness of the macular GCIPL within a 14.13-mm² elliptical annulus area centered on the fovea. The size and shape of the annulus was chosen because it conforms more closely to actual anatomy, and this annulus corresponds to the area where the RGC layer (RGCL) is thickest in normal eyes. The GCA algorithm processes data from three-dimensional volume scans using the Cirrus macular 512 × 128 × 1024 or 200 × 200 × 1024 acquisition protocol. Processing is performed in three dimensions. Data were obtained 1 month and 12 months after surgery. Changes in thinning of retinal neurofiber layer (RNFL) and GCA at 12 months post surgery were compared with those noted at 1 month.

, & Munemasa Y. (2020). Histone H2B induces retinal ganglion cell death through toll-like receptor 4 in the vitreous of acute primary angle closure patients. Laboratory Investigation; a Journal of Technical Methods and Pathology, 100(8), 1080-1089.

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Retinal Imaging with Spectral-Domain OCT

Cited 2 times

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Retinal imaging was performed using spectral-domain OCT (Cirrus HD-OCT,
Carl Zeiss Meditec, Dublin, CA), as previously described.^{16 (link)} Briefly, peri-papillary and macular
scans were obtained with the Optic Disc Cube 200×200 protocol and Macular
Cube 512×128 protocol, respectively. Scans with signal strength below
7/10, or with artifact, were excluded, in accordance with OSCAR-IB
criteria.^{15 (link),17 (link)}Peri-papillary RNFL thickness values were generated by conventional
Cirrus HD-OCT software, as described elsewhere.^{16 (link)} Segmentation of the GCIPL, inner nuclear
layer (INL) and outer nuclear layer (ONL) was performed utilizing an
open-source, validated segmentation algorithm, as previously
described.^{18 (link),19} Average thicknesses of the GCIPL, INL
and ONL were calculated within an annulus centered on the fovea, with an
internal diameter of 1mm and an external diameter of 5mm. Retinal layer
segmentation was visually inspected and verified for all scans.
OCT methods and results are reported in accordance with consensus
APOSTEL recommendations.^{20 (link)}

Filippatou A.G., Lambe J., Sotirchos E.S., Fitzgerald K.C., Aston A., Murphy O.C., Pellegrini N., Fioravante N., Risher H., Ogbuokiri E., Kwakyi O., Toliver B., Davis S., Luciano N., Crainiceanu C., Prince J.L., Mowry E.M., Calabresi P.A, & Saidha S. (2020). Association of body mass index with longitudinal rates of retinal atrophy in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England), 26(7), 843-854.

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