Micro‐CT was performed using a Siemens Inveon CT scanner (Siemens Medical Solutions, Knoxville, TN, USA). The parameters for histomorphometric analysis were as follows: 80 kV voltage, 500 μA current, 1500ms exposure time, 360° rotation, 360 projections and effective pixel size 9.29 μm. Acquisitions were collected using built‐in machine software and reconstructed using a filtered back projection algorithm.
Inveon ct scanner
Manufactured by Siemens
Sourced in United States, Germany
The Inveon CT scanner is a preclinical imaging system designed for small animal research. It provides high-resolution, three-dimensional imaging of small animals such as mice and rats. The Inveon CT scanner allows researchers to visualize and analyze the internal structures of these animals non-invasively.
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Lab products found in correlation
17 protocols using inveon ct scanner
1
Micro-CT Analysis of Bone Structure
2
Imaging Mouse Anatomy via CT
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Mice were anesthetized with 2% Isoflurane in oxygen. CT imaging was performed using Siemens Inveon CT scanner and Inveon Acquisition Workplace software (Siemens Medical Solutions USA Inc.). The datasets were loaded into Amira 5.2.2 and viewed using the Voltex display and the VolrenRed pseudo-color scale (Visage Imaging Inc).
3
In vivo Bone Mineral Density Measurement
4
Bone Regeneration Assessment via μCT
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The bone defects were evaluated by microcomputed tomography (μCT) measurement (Inveon CT scanner, Siemens, Germany) with a voltage of 90 kV and a current of 55.6 μA. The sample data obtained by μCT scanning were converted to 3D images by 3D reconstruction software (VGStudio MAX, USA). The following tissue regeneration data of 3D-reconstructed μCT images were measured and calculated: the ratio of bone volume to the total defect volume (BV/TV), the ratio of residual material volume to the total defect volume (RV/TV), and the trabecular number (Tb·N).
5
Micro-CT Analysis of Spine and Ankle
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Micro-CT was performed to analyze the structures of the spine and ankle. Obtained tissues were fixed with 4% polyoxymethylene and then scanned using a Siemens Inveon CT scanner with a resolution of 19 μm. The figure data were analyzed using RadiAnt DICOM Viewer 5.0.2 software.
6
Micro-CT Analysis of Murine Rib Cage
7
Quantifying Bone Ingrowth in Spinal Implants
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After X-ray examination, each specimen underwent micro-CT scanning using Siemens micro-CT system (Inveon CT scanner, Siemens, Germany) at 80 kV, 500 μA, and a spatial resolution of 30 μm. The acquired data (DICOM format) were exported and processed using Inveon Acquisition Workplace (IAW) (Siemens, Germany). A cylinder (diameter: 6.0 mm, length: 10 mm) with a hemispherical (diameter: 6.0 mm) tip was defined as the region of interest (ROI), covering the decompressive channel in the CD group or the porous titanium rod in the rod insertion group. New bone ingrowth in the ROI of each specimen was reconstructed with the threshold of 200-1400 for bone and 1400-4095 for implant, and the ratio of new bone volume to total volume (BV/TV) and the mean bone trabecular thickness in each ROI were calculated.
8
Small-Animal PET Imaging of DPA-714
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18F-DPA-714 was prepared as previously described with more than 99% radiochemical purity (14 (link)). PET imaging was performed with a high-resolution small-animal PET scanner (32-module quadHIDAC [Oxford Positron Systems Ltd.]; spatial resolution, <1 mm in full width at half maximum) (15 (link)).
The 18F-DPA-714 PET scan was acquired from 45 to 65 min after injection of 12.1 ± 2.0 MBq (specific activity, 40–80 GBq/μmol). Immediately afterward, a CT scan was acquired using an Inveon CT scanner (Siemens Medical Solutions; spatial resolution, 80 μm).
The 18F-DPA-714 PET scan was acquired from 45 to 65 min after injection of 12.1 ± 2.0 MBq (specific activity, 40–80 GBq/μmol). Immediately afterward, a CT scan was acquired using an Inveon CT scanner (Siemens Medical Solutions; spatial resolution, 80 μm).
9
Visualizing Spleen Vascular Changes in Parasite Infection
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To study the spleen vascular changes upon parasite infection, spleen casts were prepared. Mice were euthanized with preinjection of heparin. A 22-gauge catheter (BD) was surgically inserted into the descending aorta. The spleen was first perfused with 1× PBS followed by complete Mercox II solution (Ladd Research Industries) injected through the catheter. Mice were left overnight for Mercox II polymerization and then were immersed into 10% NaOH for tissue digestion for a period of 10 to 14 days. Spleen samples were washed with distilled water, and spleen casts were air dried and collected for analysis.
The spleen casts were scanned using an Inveon CT scanner (Siemens). The scan was acquired with 2-by-2 binning at an exposure time of 7,800 ms per projection. A total of 1,200 projections for high-resolution and high-magnification image scans were performed. The acquired images were assembled using Inveon software and then processed, reconstructed, and visualized using MatLab. The vessel complexities were analyzed using FIJI software (49 (link)). Diameters of splenic veins and splenic arteries at the points where they connect with the spleen were measured, and the numbers of venous branches were quantified.
The spleen casts were scanned using an Inveon CT scanner (Siemens). The scan was acquired with 2-by-2 binning at an exposure time of 7,800 ms per projection. A total of 1,200 projections for high-resolution and high-magnification image scans were performed. The acquired images were assembled using Inveon software and then processed, reconstructed, and visualized using MatLab. The vessel complexities were analyzed using FIJI software (49 (link)). Diameters of splenic veins and splenic arteries at the points where they connect with the spleen were measured, and the numbers of venous branches were quantified.
10
Microstructural Analysis of Vessel System
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The microstructure of the newly formed vessel system was analyzed using computer tomography (CT) scans with an Inveon CT Scanner (Siemens Healthineers, Erlangen, Germany). The following scan parameters were applied: voltage of 80 kV, current of 500 µA, resolution of 24.49 µm per voxel and exposure time of 400 ms. Osirix Dicom Viewer (Aycan Osirix, New York, NY, USA) was used as imaging software.
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