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Lcz696

Manufactured by Novartis
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Sourced in Switzerland

LCZ696 is a proprietary compound developed by Novartis for research and laboratory applications. It is a dual-acting agent that inhibits both the neprilysin and angiotensin II receptor. The core function of LCZ696 is to facilitate the study of cardiovascular and renal physiology and pathophysiology in a laboratory setting.

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Lab products found in correlation

Valsartan, by Novartis (3 mentions) Male wistar rats, by Japan SLC (1 mentions) L iso, by Merck Group (1 mentions) Valsartan, by Merck Group (1 mentions)

4 protocols using lcz696

1

Dissolution of LCZ696 and Valsartan

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LCZ696 and valsartan were purchased from Novartis, Taiwan. LCZ696 and valsartan were dissolved in normal saline. All solutions were freshly prepared on the days of experiments.
Hsu S.J., Huang H.C., Chuang C.L., Chang C.C., Hou M.C., Lee F.Y, & Lee S.D. (2020). Dual Angiotensin Receptor and Neprilysin Inhibitor Ameliorates Portal Hypertension in Portal Hypertensive Rats. Pharmaceutics, 12(4), 320.
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2

Studying LCZ696 Effects in Rats

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Male Wistar rats weighing 187–211 g were purchased from Japan SLC (Shizuoka, Japan). Rats were housed at an animal facility in a 12-h lightdark cycle and were provided with standard rat chow and water ad libitum. LCZ696 and valsartan were kindly supplied by Novartis Pharma AG (Basel, Switzerland). LCZ696 includes molecular moieties of valsartan and sacubitril at a 1:1 ratio. L-ISO was purchased from Sigma-Aldrich (St. Louis, MO, USA).
Miyoshi T., Nakamura K., Miura D., Yoshida M., Saito Y., Akagi S., Ohno Y., Kondo M, & Ito H. (2019). Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats. Cardiology Journal, 26(5), 575-583.
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3

Pharmacological Evaluation of LCZ696 and Valsartan

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LCZ696 and valsartan, an ARB, were kindly provided by Novartis Phama AG (Basel, Switzerland).
Ushijima K., Ando H., Arakawa Y., Aizawa K., Suzuki C., Shimada K., Tsuruoka S, & Fujimura A. (2017). Prevention against renal damage in rats with subtotal nephrectomy by sacubitril/valsartan (LCZ696), a dual‐acting angiotensin receptor‐neprilysin inhibitor. Pharmacology Research & Perspectives, 5(4), e00336.
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4

Oral Administration of LCZ696 and Enalapril

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LCZ696 was kindly provided by Novartis Pharma AG (Basel, Switzerland). Enalapril was purchased from Wako Pure Chemical Industries (Osaka, Japan). Both drugs were formulated in corn oil, and administered orally by gastric gavage at the beginning of the dark period once daily. Valsartan was purchased from Sigma-Aldrich (St. Louis, Missouri), and LBQ657 (an active form of sacubitril) was purchased from Toronto Research Chemicals (Toronto, Ontario, Canada), which were used in an in vitro assay.
Ishii M., Kaikita K., Sato K., Sueta D., Fujisue K., Arima Y., Oimatsu Y., Mitsuse T., Onoue Y., Araki S., Yamamuro M., Nakamura T., Izumiya Y., Yamamoto E., Kojima S., Kim-Mitsuyama S., Ogawa H, & Tsujita K. (2017). Cardioprotective Effects of LCZ696 (Sacubitril/Valsartan) After Experimental Acute Myocardial Infarction. JACC: Basic to Translational Science, 2(6), 655-668.
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