Fmoc gly oh

Manufactured by GL Biochem

Sourced in China

Fmoc-Gly-OH is a chemical compound used in solid-phase peptide synthesis. It is a protected amino acid derivative, where the amino group is protected by a fluorenylmethyloxycarbonyl (Fmoc) group and the carboxyl group is in the form of a hydroxyl (OH) group.

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Lab products found in correlation

2 chlorotrityl chloride resin, by GL Biochem (3 mentions) Fmoc ala oh, by GL Biochem (2 mentions) Phosphate buffered saline (pbs), by Thermo Fisher Scientific (2 mentions) Fmoc l phe oh, by GL Biochem (2 mentions) Fmoc phe oh, by GL Biochem (2 mentions) Fmoc arg pbf oh, by GL Biochem (2 mentions) Sylgard 184, by Dow (1 mentions) 10 12 pentacosadiynoic acid, by Thermo Fisher Scientific (1 mentions) Dipea, by GL Biochem (1 mentions) α mem medium, by Thermo Fisher Scientific (1 mentions) Fetal bovine serum (fbs), by Thermo Fisher Scientific (1 mentions) Dulbecco modified eagle medium (dmem), by Thermo Fisher Scientific (1 mentions) Avii 400, by Bruker (1 mentions) Fmoc l ala oh, by GL Biochem (1 mentions) Penicillin streptomycin, by Thermo Fisher Scientific (1 mentions) Trypsin, by Thermo Fisher Scientific (1 mentions) Gelatin, by Avantor (1 mentions) Acetonitrile, by Merck Group (1 mentions) 2 chlorotrityl chloride resin, by Merck Group (1 mentions) N n diisopropylcarbodiimide, by Biosynth (1 mentions)

Spelling variants of this product

Fmoc-Gly (2 citations)

6 protocols using fmoc gly oh

Multifunctional Elastomeric Nanocomposites

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Poly(dimethylsiloxane) (PDMS) elastomer was obtained from Dow Corning (Sylgard 184). Ag nanowires dispersed in ethanol (CST-NW-S50) were ordered from Suzhou ColdStones Technology Co., Ltd. Silicone liquid (CAF-3) was purchased from Bluestar Silicones France Co., Ltd. Ethanol (purity 99.7%) was obtained from Sinapharm Chemical Reagent Co., Ltd. Fmoc–Tyr(tBu)–2-chlorotrityl resin, Fmoc–Gly–OH, Fmoc–Ala–OH, HOBT, TBTU and DIPEA were obtained from GL Biochem Co., Ltd. (Shanghai, China). 10,12-Pentacosadiynoic acid was purchased from Alfa-Aesar Co., Ltd. All other regents, compounds, and chemicals were obtained from commercial suppliers and used without further purification.

Lu X., Zhang Z., Sun X., Chen P., Zhang J., Guo H., Shao Z, & Peng H. (2016). Flexible and stretchable chromatic fibers with high sensing reversibility †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc00414h. Chemical Science, 7(8), 5113-5117.

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Peptide Synthesis and Characterization

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2-chlorotrityl chloride resin (100–200 mesh; 1% DVB; 1.01 mmol/g), Fmoc-L-Phe-OH, Fmoc-Gly-OH and Fmoc-L-Ala-OH were purchased from Shanghai GL biochem (China). DMEM, α-MEM medium and Phosphate Buffered Saline (PBS, 0.0067 M) were provided by Thermo Fisher Scientific Corporation (USA). Fetal bovine serum (FBS, Gibco, South America origin) was bought from Life Technologies Corporation (USA). All the other compounds were obtained by Chengdu Best-reagent Corporation (China) and used without further purification. ¹H NMR spectra were collected on a Bruker AVII-400 (400 MHz, USA) using DMSO‑d₆ as a solvent. Liquid chromatography-mass spectrometry (LC-MS) analysis was performed on a Finnigan TSQ Quantum Ultra LC-MS system with an electrospray ionization (ESI) source.

Sun Y., Li X., Zhao M., Chen Y., Xu Y., Wang K., Bian S., Jiang Q., Fan Y, & Zhang X. (2021). Bioinspired supramolecular nanofiber hydrogel through self-assembly of biphenyl-tripeptide for tissue engineering. Bioactive Materials, 8, 396-408.

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Gelatin-Based Biomaterial Synthesis

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Gelatin was purchased from Avantor, Inc. Methacrylic anhydride (MA) was purchased from Aladdin Biochemical Technology Co., Ltd. (Shanghai, China). N, N-Diisopropylethylamine (DIPEA), 4-biphenyl acetic acid (BPAA), and trifluoroacetic acid (TFA) were purchased from Best-reagent Corporation (Chengdu, China). Fmoc-L-Phe-OH, Fmoc-Gly-Oh, and 2-chlorotrityl chloride resin were provided from Shanghai GL biochem (Shanghai, China). Phosphate buffered saline (PBS) was bought from Invitrogen. Dulbecco’s Modified Eagle Medium (DMEM), fetal bovine serum (FBS), type II collagenase, trypsin, and penicillin/streptomycin (PS) were bought from Gibco (USA). α-MEM medium was purchased from Hyclone (USA). Type I collagen was extracted and purified from new-born calf skin in our laboratory. All other chemicals were used as received unless otherwise specified.

Zhao C., Li X., Han X., Li Z., Bian S., Zeng W., Ding M., Liang J., Jiang Q., Zhou Z., Fan Y., Zhang X, & Sun Y. (2024). Molecular co-assembled strategy tuning protein conformation for cartilage regeneration. Nature Communications, 15, 1488.

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Solid-Phase Peptide Synthesis Reagents

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Iris Biotech (Marktredwitz, Germany): N,N-dimetylformamide (DMF), dichloromethane (DCM), trifluoroacetic acid (TFA), 2-chlorotrityl chloride resin (CTC), 4-methylbenzhydryl bromide resin (Br-MBH), and Oxyma-B. Merck KGaA (Darmstadt, Germany): Acetonitrile (MeCN) for mass spectrometry (MS) (>99.9%), TFA for MS (>99.9%), diisopropyl ether, ammonium iodide, triisopropylsilane (TIS), isopropylamine (IPA), tosyl chloride, tetrabutylammonium hydroxide (TBA-OH), ethanedithiol (EDT), diisopropylethylamine (DIPEA), and hexafluoroisopropanol (HFIP). Carbosynth (San Diego, CA, USA): Ethyl (hydroxyimino) cyanoacetate (OxymaPure) and N,N′-diisopropylcarbodiimide (DIC). GL Biochem (Shanghai, China): Fmoc-Ala-OH (Fmoc, fluorenyl-9-methyloxycarbonyl), Fmoc-Ser(tBu)-OH, Fmoc-Gln(Trt)-OH, Fmoc-Gly-OH, Boc-His(Trt)-OH, Fmoc-Phe-OH, Fmoc-Nal-OH, Fmoc-Asn(Trt)-OH, Fmoc-Met-OH, Fmoc-Leu-OH, Fmoc-Trp(Boc)-OH, Fmoc-Val-OH, Fmoc-Asp(tBu)-OH, Fmoc-Arg(Pbf)-OH, Fmoc-L-Asp(OtBu)-L-Ser[psi(Me,Me)pro]-OH, Fmoc-Tyr(tBu)-OH, Fmoc-Lys(Boc)-OH, and Fmoc-Thr(tBu)-OH.

Orlandin A., Guryanov I., Ferrazzano L., Biondi B., Biscaglia F., Storti C., Rancan M., Formaggio F., Ricci A, & Cabri W. (2022). Carbodiimide-Mediated Beckmann Rearrangement of Oxyma-B as a Side Reaction in Peptide Synthesis. Molecules, 27(13), 4235.

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Solid-Phase Peptide Synthesis of Fmoc-protected Amino Acids

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N-Fluorenyl-9-methoxycarbonyl (Fmoc) protected amino acids (Fmoc-Trp(Boc)-OH, Fmoc-Phe-OH, Fmoc-Arg(Pbf)-OH, Fmoc-Asp(OtBu)-OH), Fmoc-Gly-OH, 2-chlorotrityl chloride resin (100–200 mesh, loading: 0.97 mmol g⁻¹, 1% DVB), N-hydroxybenzotriazole (HOBt) and o-benzotriazole-N,N,N′,N′-tetramethyluroniumhexafluorophosphate (HBTU) were purchased from GL Biochem. Ltd (Shanghai, China) and used as received. Trifluoroacetic acid (TFA) and diisopropylethylamine (DIEA) were provided by Aladdin Reagent Co. Ltd (Shanghai, China). Piperidine, N,N-dimethylformamide (DMF) and triisopropylsilane (TIS) were obtained from Sinopharm Chemical Reagent Co., Ltd (Shanghai, China) and used as received. Rhodamine B was obtained from Aladdin. Dulbecco's Modified Eagle's Medium (DMEM), fetal bovine serum (FBS), and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetra-zoliumbromide (MTT) were provided by Invitrogen Corp. All other chemical agents were purchased from Sinopharm Chemical Reagent Co., Ltd and used without any pre-treatment.

Ding W.Q., Qin S.Y., Cheng Y.J., Ma Y.H, & Zhang A.Q. (2018). Novel oligopeptide nanoprobe for targeted cancer cell imaging. RSC Advances, 8(54), 30887-30893.

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Solid-Phase Peptide Synthesis Protocol

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Fmoc-Gly–OH, Fmoc-Lys (Fmoc)–OH, Fmoc-Lys (Boc)–OH, Fmoc-Arg (Pbf)–OH, O-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) were purchased from GL Biochem (Shanghai) Ltd, China. Rink amide resin (200–400 mesh, loading capacity 0.34 g mmol⁻¹) was purchased from Chem-impex International, Inc (USA). The solvent used throughout the synthesis was peptide grade N,N-dimethylformamide (DMF; Merck Australia), trifluoroacetic acid (TFA), N,N-diisopropylethylamine (DIEA), dichloromethane (DCM), triisopropylsilane (TIPS), piperidine, were purchased from Sigma-Aldrich (Australia).

Jing J., Tupally K.R., Kokil G.R., Qu Z., Chen S, & Parekh H.S. (2019). Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine. RSC Advances, 9(5), 2458-2463.

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