Trpa1 ko

Manufactured by Jackson ImmunoResearch

Trpa1-KO is a knockout mouse model that lacks the Trpa1 gene, which encodes the Transient Receptor Potential Ankyrin 1 ion channel. This model is used for research purposes to investigate the physiological functions of the Trpa1 channel.

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Lab products found in correlation

Trpv1 ko, by Jackson ImmunoResearch (2 mentions) C57bl 6j, by Jackson ImmunoResearch (2 mentions) Mafia, by Jackson ImmunoResearch (1 mentions)

Close spelling variants of this product

TRPA1-KO mice (5 citations) TRPA1 (8 citations)

2 protocols using trpa1 ko

Postmortem Skin and Transgenic Mouse Analysis

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We obtained approval from the National Institutes of Health Office of Human Subjects Research and Protection to obtain and analyze fully deidentified postmortem donor skin specimens provided by the Washington Regional Transplant Community (Falls Church, VA). All animal experiments were approved by the Institutional Animal Care and Use Committee at NC State University (Raleigh, NC) (Institutional Animal Care and Use Committee number 19-167-B) and the National Institutes of Health (Institutional Animal Care and Use Committee number 1402-17). Mice and rats were housed in standard conditions with a 12/12-hour light‒dark cycle with ad libitum access to food and water. Trpv1-KO (stock number 003770), Trpa1-KO (stock number 006401), and C57Bl6/J (stock number 000664) mice were ordered from the Jackson Laboratory (Bar Habor, ME). Trpv1- and Trpa1-KO mice were maintained on the C57Bl6/J background.

Wheeler J.J., Domenichiello A.F., Jensen J.R., Keyes G.S., Maiden K.M., Davis J.M., Ramsden C.E, & Mishra S.K. (2022). Endogenous Derivatives of Linoleic Acid and their Stable Analogs Are Potential Pain Mediators. JID Innovations, 3(2), 100177.

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Mice Handling and Housing for Experiments

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All experiments involving mice and the procedures used therein were approved by the University of Iowa Institutional Animal Care and Use Committee and were carried out in strict accordance with the NIH Guide for the Care and Use of Laboratory Animals. Every effort was made to minimize the number of mice used and their suffering. Mice (6–10 weeks of age) were housed with food and water ad libitum under a 12-hr light/dark cycle. C57BL/6J, TRPV1 KO (Jackson Labs #003770; C57BL/6J), TRPA1 KO (Jackson Labs #006401; mixed B6;129) and MAFIA (Jackson Labs #005070; C57BL/6J) mice were obtained from The Jackson Laboratory (Farmington, CT).

Warwick C.A., Shutov L.P., Shepherd A.J., Mohapatra D.P, & Usachev Y.M. (2019). Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1 and CGRP receptors. Pain, 160(3), 702-711.

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