S dhpg

Manufactured by Bio-Techne

Sourced in Mongolia

S-DHPG is a biochemical reagent manufactured by Bio-Techne. It is a synthetic compound that serves as a structural analog of the neurotransmitter dopamine. The core function of S-DHPG is to act as a research tool for studying dopaminergic systems and related biological processes.

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Lab products found in correlation

Mg132, by Bio-Techne (2 mentions) Hli373, by Merck Group (2 mentions) Okadaic acid, by Enzo Life Sciences (1 mentions) Picrotoxin, by Bio-Techne (1 mentions) Cgp 52432, by Bio-Techne (1 mentions) L name, by Bio-Techne (1 mentions) Dpcpx, by Bio-Techne (1 mentions) Forskolin, by Thermo Fisher Scientific (1 mentions) Phospho pkcpan, by Cell Signaling Technology (1 mentions) Cdppb, by Bio-Techne (1 mentions)

Close spelling variants of this product

S)-3,5-DHPG (S)-3,5-Dihydroxyphenylglycine (DHPG)

5 protocols using s dhpg

Pharmacological Inhibition Assays

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Rapamycin (Cat. No. tlrl-rap, InvivoGen), PF-470867 (Symansis), Bisindolylmaleimide V (B5) (Cat. No. ALX-270-053, Enzo Life Sciences), and okadaic acid (Cat. No. ICN15897310, MP Biomedicals) were used as indicated in the text. okadaic acid was dissolved in ethanol (vehicle 2) for N2a cell culture experiments and DMSO when used to supplement lysis buffers. (S)-DHPG was purchased from Tocris and diluted in water.

Bartley C.M., O’Keefe R.A, & Bordey A. (2014). FMRP S499 Is Phosphorylated Independent of mTORC1-S6K1 Activity. PLoS ONE, 9(5), e96956.

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Pharmacological Modulation of Neuronal mGluR

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S-DHPG (Tocris, Mineapolis, MN) was used at 50 μM to activate mGluR in neurons.
MG132 (Tocris, Mineapolis, MN), a preoteasome inhibitor was used at concentration of 10 uM.
HLI373 (Sigma, St. Louis, MO), a Hdm2 E3 Ligase Inhibitor was used at a concentration of 5μM (Kitagaki et al., 2008 (link)).

Ifrim M.F., Janusz-Kaminska A, & Bassell G.J. (2022). Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites. Cell reports, 41(7), 111658.

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Pharmacological Agents for Neurological Research

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CGP 52432 3-[[(3,4-dichlorophenyl)methyl]amino]propyl diethoxymethylphosphinic acid, DPCPX (8-cyclopentyl-1,3-dipropylxanthine), MPPG ((RS)-α-methyl-4-phosphonophenylglycine), S-DHPG ((S)-3,5-dihydroxyphenylglycine), NMDA (N-methyl-D-aspartic acid), ODQ (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one), L-NAME (NG-nitro-L-arginine methyl ester hydrochloride), and picrotoxin were purchased from Tocris Bioscience (Bristol, UK). BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid) and SR141716 (rimonabant hydrochloride) were purchased from VWR International (Lutterworth, Leicestershire, UK). Forskolin was purchased from Fisher Scientific (Loughborough, Leicestershire, UK). Stock solutions of SR141716 and DPCPX were prepared in DMSO, with a final DMSO concentration of less than 0.5%. All other drugs were dissolved directly into the bath solution.

Dobson K.L, & Bellamy T.C. (2015). Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum. Neural Plasticity, 2015, 602356.

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Pharmacological Modulation of Neuronal mGluR

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Investigating Metabotropic Glutamate Receptor Signaling

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S-DHPG [(S)-3, 5-dihydroxyphenylglycine] and CDPPB (3-cyano-N-(1, 3-diphenyl-1H-pyrazol-5-yl) benzamide), were purchased from Tocris Bioscience (Ellisville, MO). Polyclonal antibodies against total-ERK 1/2 (Cat#9102) phospho-ERK1/2 (phosphorylated at Thr202 and Tyr204 of Erk1;Thr185 and Tyr187 of Erk2, Cat#9101), and phospho-PKC (Pan) (autophosphorylated at carboxy terminal Ser660 residue; Cat #9371) were from Cell Signaling (Beverly, Massachusetts, USA). Monoclonal antibody against mGluR1 was purchased from BD Transduction (Franklin Lakes, NJ). Polyclonal antibody for mGluR5 was obtained from Upstate Biotechnology (Lake Placid, NY). Antibody against the housekeeping protein β-actin was from Sigma (St. Louis, Missouri, USA). All other materials were purchased from commercial sources.

Bhardwaj S.K., Ryan R.T., Wong T.P, & Srivastava L.K. (2015). Loss of dysbindin-1, a risk gene for schizophrenia, leads to impaired group 1 metabotropic glutamate receptor function in mice. Frontiers in Behavioral Neuroscience, 9, 72.

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