1100 series lc msd ion trap mass spectrometer

Manufactured by Agilent Technologies

Sourced in United States

The 1100 series LC/MSD ion trap mass spectrometer is a laboratory instrument designed for the analysis of chemical compounds. It combines liquid chromatography (LC) with mass spectrometry (MS) to separate, detect, and identify various substances. The core function of this device is to provide high-sensitivity, high-resolution mass analysis capabilities for a wide range of applications.

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Lab products found in correlation

Rp 18, by YMC (1 mentions) Ods a column, by YMC (1 mentions) Lc 10at, by Shimadzu (1 mentions) Diaion hp 20, by Mitsubishi (1 mentions) P 2000 polarimeter, by Jasco (1 mentions) Am 400, by Bruker (1 mentions) Lh 20, by GE Healthcare (1 mentions) Lc 6ad instrument, by Shimadzu (1 mentions) 7890a instrument, by Agilent Technologies (1 mentions) Ods a column, by Shimadzu (1 mentions) Aviii hd 600, by Bruker (1 mentions) V 650 spectrophotometer, by Jasco (1 mentions) Chiralpak ad h column, by Daicel (1 mentions)

Close spelling variants of this product

Agilent 1100 Series LC/MSD high-performance ion trap mass spectrometer Agilent 1100 series LC/MSD ion trap mass spectrometer Agilent 1100 series LC/MSD XCT plus ion trap mass spectrometer 1100 series ion trap mass spectrometer LC/MSD ion trap mass spectrometer 1100 Series LC/MSD Trap 1100 ion trap MSD spectrometer MSD ion trap mass spectrometer 1100 Series LC/MSD spectrometer LC/MSD ion trap

4 protocols using 1100 series lc msd ion trap mass spectrometer

Synthesis and Administration of PEG-Pam2Cys

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Pam₂Cys is insoluble in physiological media and was therefore synthesized with a polyethylene glycol molecule attached to confer solubility for intravenous (i.v.) administration. Synthesis was performed in house using Fmoc-based chemistry as described previously (Tan et al., 2012 (link)). Fidelity of synthesis and the purification process was monitored by mass analysis (mass value found 1502.2 Da; expected mass 1502.1 Da) using an Agilent 1100 Series LC/MSD ion-trap mass spectrometer (Agilent, Palo Alto, CA, USA).
PEG-Pam₂Cys was administered to mice at varying doses in 100  μL of PBS by the i.v. route via the tail vein. The lowest effective dose of Pam₂Cys was used for each experiment, according to calibration in pilot studies.

Ernest M., Hunja C., Arakura Y., Haraga Y., Abkallo H.M., Zeng W., Jackson D.C., Chua B, & Culleton R. (2018). The Toll-Like Receptor 2 agonist PEG-Pam2Cys as an immunochemoprophylactic and immunochemotherapeutic against the liver and transmission stages of malaria parasites. International Journal for Parasitology: Drugs and Drug Resistance, 8(3), 451-458.

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Spectroscopic Characterization of Compounds

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The IR spectra were obtained using an IMPACT 400 (KBr) spectrometer. ¹H NMR (500 MHz), ¹³C NMR (125 MHz), and 2D-NMR spectra were recorded with an INOVA-500 spectrometer with TMS as an internal standard. Values were given in ppm. HRESIMS were obtained using an Agilent 1100 series LC/MSD ion trap mass spectrometer. The optical rotations were measured with a Jasco P-2000 polarimeter. Column chromatography was performed on macroporous resin (Diaion HP-20, Mitsubishi Chemical Corp., Tokyo, Japan), Rp-18 (50 μm, YMC, Kyoto, Japan), and Sephadex LH-20 (Pharmacia Fine Chemicals, Uppsala, Sweden). Preparative HPLC separation was performed using a Shimadzu LC-10AT instrument with an SPD-10A detector using a YMC-Pack ODS-A column (250 mm × 20 mm, 5 μm).

Feng Z.M., Zhan Z.L., Yang Y.N., Jiang J.S, & Zhang P.C. (2016). Naturally occurring hybrids derived from γ-amino acids and sugars with potential tail to tail ether-bonds. Scientific Reports, 6, 25443.

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Characterization of Organic Compounds

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¹H NMR spectra
were recorded on Bruker AM 400 and 600 MHz spectrometers with tetramethylsilane
(TMS) as the internal standard. Electrospray ionization mass spectra
(ESI-MS) were recorded using an Agilent 1100 series LC/MSD ion trap
mass spectrometer. Melting points (m.p.) were recorded on a SRS OptiMelt-100
full automatic micro melting point instrument. Column chromatography
(CC): silica gel (200–300 mesh; Qingdao Makall Group Co., Ltd;
Qingdao; China). All reactions were monitored using thin-layer chromatography
(TLC) on silica gel plates. Reaction reagents were of analytical reagent
grade and purchased from Aladdin.

Li D.D., Yu P., Wang Z.Z., Xiao W., Zhou X.H, & Zhao L.G. (2020). Discovery of 7,9-Disulfatetrahydroberberine as Novel Lipid-Lowering Agents. ACS Omega, 5(48), 30836-30848.

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Comprehensive Analytical Techniques for Chemical Analysis

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Optical rotations were measured on a JASCO P2000 automatic digital polarimeter. UV spectra were recorded on a JASCO V-650 spectrophotometer. IR spectra were recorded on a Nicolet 5700 spectrometer using an FT-IR microscope transmission method. NMR spectra were acquired with Bruker AVIIIHD 600, VNS-600, or Mercury-400 spectrometers in DMSO-d₆. HRESIMS spectra were collected on an Agilent 1100 series LC/MSD ion trap mass spectrometer. MPLC system was composed of two C-605 pumps (Büchi), a C-635 UV detector (Büchi), a C-660 fraction collector (Büchi), and an ODS column (450 mm×60 mm, 50 μm, 400 g; YMC). Semi-preparative HPLC was conducted using a Shimadzu LC-6AD instrument with an SPD-20A detector and a Daicel Chiralpak AD-H column (250 mm×10 mm, 5 μm). Preparative HPLC was also performed on a Shimadzu LC-6AD instrument with a YMC-Pack ODS-A column (250 mm×20 mm, 5 μm). Column chromatography (CC) was performed with silica gel (200–300 mesh, Qingdao Haiyang Chemical Inc., Qingdao, China), SF-PRP 512 A (100–200 mesh, Beijing Sunflower and Technology Development Co., Beijing, China), ODS (50 μm, YMC, Japan), and Sephadex LH-20 (GE, Sweden). TLC was carried out on glass precoated silica gel GF254 plates. Spots were visualized under UV light or by spraying with 10% sulfuric acid in EtOH followed by heating. GC analyses were obtained using an Agilent Technologies 7890A instrument.

Zhang C., Zhou J., Yang J., Li C., Ma J., Zhang D, & Zhang D. (2016). Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata. Acta Pharmaceutica Sinica. B, 6(6), 564-567.

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