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23 protocols using somatom edge plus

1

Ultra-Low-Dose Pelvic CT with Tin Filtration

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The standard non-contrast CT of the osseous pelvis without tin filtration was part of the clinical routine imaging workup at Balgrist University Hospital either on a 64-slice CT scanner (SOMATOM Definition AS, Siemens Healthineers) or on a 128-slice CT scanner (SOMATOM Edge Plus, Siemens Healthineers). On both CT scanners, images were acquired with automated tube voltage selection (CARE kV, reference 120kV) and tube current modulation (CARE Dose4D, reference 147mAs), a collimation width of 0.6 mm, a rotation time of 0.5 s, and a pitch of 0.8.
After the standard CT, all study participants received a non-contrast ultra-low-dose pelvic CT with tin filtration (protocol Sn140kV/50mAs) of the same coverage in the z-axis on the 128-slice CT scanner (SOMATOM Edge Plus, Siemens Healthineers) either at Balgrist University Hospital or at the Swiss Center for Musculoskeletal Imaging. The ULD-CT protocol was developed in pelvic cadavers, which is shown in the supplementary material. Settings of the ULD-CT protocol were as follows: a fixed tube voltage of 140 kV with tin filtration (Sn), fixed tube current of 50mAs, collimation width of 0.6 mm, rotation time of 1 s, and a pitch of 0.8.
Both the standard CT and ULD-CT were acquired in supine position with 15° internal rotation of the legs.
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2

Standardized CT Imaging Protocol for Evaluation

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CT scan was performed based on the clinical judgment of the attending physician and was performed in the supine position, and the image was taken in the craniocaudal direction. In total, 47 of the CT examinations were conducted at our institution, and SOMATOM Edge Plus (Siemens Healthcare GmbH, Erlangen, Germany) with 64-detector rows was utilized. Conversely, 32 CT examinations were conducted outside our institutions, and several CTs with 4- to 320-detector rows were utilized. The acquisition parameters at our hospital were as follows: 120-kV tube voltage with automatic tube current modulation (150 mAs); tube rotation time, 0.28 s; beam collimation, 128 ch × 0.6 mm; and beam pitch, 1.5. By default, 2.0 mm chest CT images without interslice gap were reconstructed using a sharp tissue kernel (Bl57) and the filtered back-projection technique. Outside institutions, the slice thickness of the reconstructed images ranged from 1.25 to 5 mm.
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3

COVID-19 Chest CT Imaging Protocol

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Chest CT studies were performed using a variety of vendors and systems: SOMATOM Definition AS (Siemens Healthineers, Erlangen, Germany [n = 50]); SOMATOM Edge Plus (Siemens Healthineers, Erlangen, Germany [n = 35]); SOMATOM Perspective (Siemens Healthineers, Erlangen, Germany [n = 2]); LightSpeed VCT (GE Healthcare, Chicago, United States [n = 33]); Revolution HD (GE Healthcare, Chicago, United States [n = 13]); Revolution EVO (GE Healthcare, Chicago, United States [n = 6]); and Aquilion Prime (Canon Medical Systems, Otawara, Japan [n = 13]). A non-contrast chest CT was performed on patients with COVID-19 symptoms to evaluate for potential pneumonia lesions (n = 46), and a chest CT angiogram with iodine contrast [100–200 mL of Iopamidol (Isovue, Bracco Diagnostics), depending on patient's weight, administered by bolus injection] was performed in patients in whom pulmonary embolic disease was suspected (n = 106). CT acquisition parameters are listed in Supplementary Table 1.
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4

Evaluating Cervical Spine Revision Surgery

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One year postoperatively, a spiral 128-slice multidetector CT image (SOMATOM Edge Plus, Siemens Healthcare GmbH, Erlangen, Germany) with a slice thickness of < 1 mm was obtained from all revised cervical spines. Detection of a solid bone bridge on CT scan one year postoperatively was defined as radiological success of revision surgery. Because of the higher sensitivity and specificity for assessing the internal and external bone bridge compared with conventional radiographs or dynamic flexion-extension radiographs [5 (link)], the success of the revision procedure was evaluated primarily on the basis of postoperative CT scans in the sagittal, transverse, and coronal planes using Merlin 5.2. (Phoenix-PACS, Freiburg, Germany) by a board-certified musculoskeletal radiologist and a fellowship-trained orthopaedic surgeon.
Furthermore, operative time, radiographic exposure, blood loss, and hospitalization time were analyzed.
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5

Knee Joint Calcification Detection via CT

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CT was chosen as imaging reference standard for detection of calcification based on (1) the high contrast between calcifications and cartilage and (2) the three-dimensional tomographic nature, thereby offering a more appropriate reference standard (as opposed to two-dimensional radiographs) when evaluating MRI as index test. After inclusion, each patient underwent a CT of the respective knee joint on a 128-detector row CT scanner (SOMATOM Edge Plus, Siemens Healthcare). The image datasets were acquired with a slice thickness of 0.5 mm and a pitch of 0.8, followed by a reconstruction in the axial (2 mm), coronal (2 mm), and sagittal plane (2 mm) using a dedicated bone kernel (Br60). Advanced Modeled Iterative Reconstruction (ADMIRE) level 3 was used for image reconstructions.
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6

DECT Shoulder Imaging Protocol

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All patients received a dual energy CT scan of the shoulder at Balgrist University Hospital either on a 128-slice CT scanner (SOMATOM Edge Plus, Siemens Healthineers, Erlangen, Germany; CT 1) or on a 64-slice CT scanner (SOMATOM Definition AS, Siemens Healthineers, Erlangen, Germany; CT 2) within 15 min after arthrography. The scan protocol was adapted from the protocol for the liver VNC application since no shoulder-specific manufacturer settings were available: All scans were performed in sequential technique with a 80 kV scan followed by a second scan with 140 kV of the same coverage in z-axis. Both CT scanners operated with automated tube current modulation (CARE Dose4D, reference 240 mAs for 80 kV and 57 mAs for 140 kV), a collimation width of 0.6 mm, a rotation time of 0.5 s, and a pitch of 0.8. The dose settings of the DECT scan were adjusted to the parameters of a single energy scan of the shoulder at 120 kV (reference 150 mAs). The applied total dose was split automatically between the 80 kV and the 140 kV scan by the CT machine.
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7

Augmented Reality Spine Surgery Navigation

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Preoperative CT scans (SOMATOM Edge Plus, Siemens Healthcare GmbH, Erlangen, Germany) with a slice thickness of 1 mm were acquired. 3D triangular surface models were reconstructed from the segmented vertebrae using a commercial segmentation software (Mimics 19.0, Materialise NV, Leuven, Belgium).
Pedicle screw insertion points and trajectories were planned in 3D using our in-house developed preoperative planning software (CASPA, University Hospital Balgrist, Zurich, Switzerland). In the planning software, the screw trajectories were represented as cylinder primitives which were brought into the desired positions and orientations by an experienced spine surgeon. The entry points of the screws were defined at the intersection between the superior articular process and the transverse process. The trajectories of the screws were planned to be centrally within the pedicles.
The data about entry points (3D points), trajectories (3D direction vectors) and 3D bone models were loaded on the Hololens 2 application and served as the basis for our navigation approach which is described in the following section.
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8

Single-source EID-CT Phantom Scans

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For reference, the same chest phantom was scanned four times in the sequential mode on a single-source EID-CT (SOMATOM Edge Plus; Siemens Healthineers; Forchheim, Germany) at 120 kV. The tube current-time product was adjusted to achieve an identical CTDIvol of 2.0, 3.8, 6.4, and 8.6 mGy as with PCD-CT. Images were reconstructed as follows: FBP, Sa36 kernel, 3 mm slice thickness, and 1.5 mm increment.
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9

Evaluating Extranodal Extension in HPV+ Oropharyngeal Cancer

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Twenty-four patients with a pathologically confirmed diagnosis of HPV+ OPC were included in this analysis. Demographic characteristics of patients used in this study are shown in Table 1. All patients received lymph node dissection confirming the presence or absence of pathological ENE. Specifically, lymph nodes from 17 patients exhibited the presence of histopathological ENE, while lymph nodes from the 7 remaining patients did not (ENE absent). Pre-surgery contrast-enhanced CT images for these patients were retrospectively acquired from The University of Texas MD Anderson Cancer Center picture archiving system. All images were collected in Digital Imaging and Communications in Medicine (DICOM) format. Data were collected under a HIPAA-compliant protocol approved by The University of Texas MD Anderson Cancer Center Institutional Review Board (RCR03-0800 and PA19-0491) which gave ethical approval for this work. CT images were acquired on various scanner devices (GE Discovery CT750 HD = 16; GE Revolution HD = 3; GE LightSpeed VCT = 3; GE Revolution GSI = 1; Siemens SOMATOM Edge Plus = 1) using a diagnostic head and neck CT imaging protocol with intravenous contrast administration. CT acquisition parameters are shown in Table 2.
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10

Tin-Filtered Low-Dose CT of Instrumented Spine

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The clinically indicated non-contrast standard CT without tin filtration of the instrumented lumbar spine was performed on a 128-slice CT scanner (SOMATOM Edge Plus, Siemens Healthineers, Erlangen, Germany). For all standard CT scans automated tube current modulation (CARE Dose4D, reference 250 mAs) was activated, tube voltage was set to 120 kV and further parameters were a collimation width of 0.6 mm, a rotation time of 1 s and a pitch of 0.8.
Immediately following the standard CT, all study participants were additionally scanned over the identical coverage in z-axis with the non-contrast tin-filtered low-dose CT protocol on the same CT machine. Parameters of the tin-filtered LD-CT scan protocol were: fixed tube voltage (Sn 140 kV), active automated tube current modulation (CARE Dose4D, reference 250 mAs), a collimation width of 0.6 mm, a rotation time of 1 s and a pitch of 0.8.
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