Idebenone

Manufactured by Cayman Chemical

Sourced in United States

Idebenone is a synthetic analogue of coenzyme Q10 that functions as an antioxidant. It is primarily used in biochemical and cell biology research applications.

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Lab products found in correlation

4 protocols using idebenone

Chemical Compounds for Cell Death Study

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1S,3R-RSL3 (referred to as RSL3) (#19288), Ferrostatin-1 (#17729), idebenone (#15475), Deferoxamine (DFO, #14595), Erastin2 (#27087), ML162 (#20455), ZVAD(OMe)-FMK (#27421), Necrostatin-1 (#11658), IKE (Imidazole Ketone Erastin, #27088), Tocopherol (#25985) Auranofin(#15316), Sulfasalazine(#15025) were all purchased from Cayman Chemical. Etoposide (#E1383), chloroquine (#C6628), and sodium selenite (#S5261), were all purchased from Sigma-Aldrich. Blasticidin S HCl (A1113903), Puromycin (A1113803), Hygromycin B (#10687010), SYTOX Green Dead Cell Stain (#34860), and MitoTracker Deep Red FM (M22426) were all purchased from Thermo Fisher Scientific.

Li Z., Ferguson L., Deol K.K., Roberts M.A., Magtanong L., Hendricks J.M., Mousa G.A., Kilinc S., Schaefer K., Wells J.A., Bassik M.C., Goga A., Dixon S.J., Ingolia N.T, & Olzmann J.A. (2022). Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability. Nature chemical biology, 18(7), 751-761.

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Biochemical Reagents for Cell Studies

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Bacterial lipopolysaccharide (LPS), iodoacetic acid (IAA), 2-deoxyglucose (2DG), indomethacin, 2-thenoyltrifluoroacetone (TTFA), oligomycin, rotenone, antimycin A and myxothiazol were from Sigma Aldrich (St. Louis, MO, USA). GKT137831, zileuton, PD146176, idebenone, piericidin A, trifluoromethoxy carbonylcyanide phenylhydroazone (FCCP), S-ethyl isothiourea (SEITU) and 1400W were from Cayman Chemical (Ann Arbor, MI, USA). GSK2795039 was from MedChem Express (Monmouth Junction, NJ, USA). All other chemicals were from Sigma Aldrich.

, & Maher P. (2021). Investigations into the Role of Metabolism in the Inflammatory Response of BV2 Microglial Cells. Antioxidants, 10(1), 109.

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Comprehensive Chemical Reagent Library

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Bafilomycin (11038), BI-6C9 (17265), bisindoylmaleimide III (11072),
chlorgyline (15925), erastin (17754), trifluoromethoxycarbonylcyanide
phenylhydrazone (FCCP; 15218), (ferrostatin (17729), Flt 3 inhibitor (21193),
GKT137831 (17764), idebenone (15475), liproxstatin (17730), LY83583 (70230),
mitoquinol (mitoQ; 89950), Nullscript (16433), PD146176 (10010518), PI3K
inhibitor VIII (10009210), RSL3 (19288), Scriptaid (10572), STY-BODIPY (27089),
2-theonyl trifluoroacetone (TTFA; 15517) and troglitazone (71750) were purchased
from Cayman Chemical (Ann Arbor, MI USA). GSK2795039 (HX18950) was from MedChem
Express (Monmouth Junction, NJ USA). Cisplatin (2251) was from Tocris
(Minneapolis, MN USA). Antimycin A (A8674), (aminooxy)acetic acid
hemihydrochloride (AOA; C13408), apomorphine (A4393), CdCl₂ (202908),
8-(4-chlorophenylthio)-guanosine 3’,5’-cyclic monophosphate
(pCPT-cGMP; C5438), CoCl₂ (C2644), deferiprone (379409), glutamate
(G5889), glutaminase inhibitor 968 (SML1327), hydrogen peroxide
(H₂O₂; H1009), 6-hydroxydopamine (6OHDA; H4391),
iodoacetic acid (I4386), myxothiazol (T5580), paraquat (36541), rotenone
(45656), sodium azide (S8032), tert-butyl hydroperoxide (tBOOH; B2633) and all
other chemicals were purchased from Sigma-Aldrich (St. Louis, MO USA) unless
otherwise stated.

Soriano-Castell D., Currais A, & Maher P. (2021). Defining a Pharmacological Inhibitor Fingerprint for Oxytosis/Ferroptosis. Free radical biology & medicine, 171, 219-231.

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High-throughput screening of chemical library

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Prestwick FDA Approved Chemical Library was provided by MSU Assay Development and Drug Repurposing Core (ADDRC). R-(−)-apomorphine hydrochloride, raloxifene hydrochloride, fosinopril, nifedipine, nisoldipine, idebenone, itraconazole, prednicarbate, carmofur, diazepam, flurazepam, temazepam, prazepam, nitrazepam, nimetazepam, nordiazepam and oxazepam were from Cayman Chemical (Ann Arbor, MI). Devazepide was purchased from Santa Cruz Biotechnology (Dallas, Texas). Fluorescein diacetate, propidium iodide, clofazimine, hexachlorophene, hydralazine hydrochloride, thioflavin S and Amicon Centrifugal Filter Unit were purchased from Sigma Aldrich (St. Louis, MO). Gibco Dulbecco’s Modified Eagle Medium (DMEM), HyClone™ Fetal Bovine Serum, Optical Adhesive Film and FITC-Annexin V were purchased from Thermo Fisher Scientific (Waltham, MA). All other chemicals for common buffers and solutions were from Sigma Aldrich.

Liu M., Dexheimer T., Sui D., Hovde S., Deng X., Kwok R., Bochar D.A, & Kuo M.H. (2020). Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions. Scientific Reports, 10, 16551.

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