Scirocco 2000 dry powder module

Laser diffraction (Mastersizer 2000, Malvern Instruments Ltd., UK) was used to measure the particle size distribution of spray dried formulations. Powders were loaded onto Scirocco 2000 dry powder module (Malvern Instruments, UK) and dispersed using compressed air at 4.0 bars. Volumetric diameters (D₁₀, D_50, and D₉₀) and span ((D₉₀–D₁₀)/D₅₀) were reported. All measurements were performed in triplicate.

Optical particle size distributions of the powder formulations were measured using a Malvern Mastersizer 2000 (Malvern Instruments, UK). The powders were dispersed through the measurement window with compressed air at 350 kPa using a Scirocco 2000 dry powder module (Malvern Instruments, UK). The real, imaginary and dispersant (air) refractive indices were set at 1.52, 0.1 and 1.0, respectively. All measurements were done in triplicate. The size distribution was expressed by the volume median diameter (VMD), and span defined as the difference in the particle diameters at 10% and 90% cumulative volume divided by the VMD.

The particle size distribution was measured on a Malvern Mastersizer 2000 (Malvern Instruments, UK). The powder was loaded onto Scirocco 2000 dry powder module (Malvern Instruments, UK) and then dispersed using compressed air at 4.0 bar. The results were reported as volumetric diameters at the 10^th, 50^th and 90^th percentiles (D₁₀, D₅₀, and D₉₀) and span (defined as (D₉₀-D₁₀)/D₅₀). All measurements were conducted in triplicate.