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Inveon research workspace 4

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Inveon Research Workspace 4.2 is a software suite designed to facilitate the operation and analysis of pre-clinical imaging data. It provides a comprehensive platform for managing and analyzing data from various imaging modalities such as PET, SPECT, CT, and MRI. The software offers a user-friendly interface and a range of tools for image reconstruction, visualization, and quantitative analysis.

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Lab products found in correlation

Inveon acquisition workspace, by Siemens (3 mentions) Prism 8, by GraphPad (2 mentions) Automatic gamma counter, by PerkinElmer (1 mentions) Asipro, by Siemens (1 mentions) Imagej, by Leica (1 mentions) Las x, by Leica (1 mentions) Inveon hybrid micro pet ct scanner, by Siemens (1 mentions)

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Inveon Research Workspace Inveon

5 protocols using inveon research workspace 4

1

PET/CT Imaging of Candida Infection in Mice

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Three mice from each group were anaesthetized by intraperitoneal injection of 1% pentobarbital and tails were intravenously injected with [18F]FDG (Guangzhou HTA Isotope Medical Co. Ltd) (10–11 MBq) at 24, 48 and 72 h after infection with C. albicans (5 × 105 CFU). Forty minutes after the injection, the mice were scanned with a small-animal PET/CT scanner (Inveon) for 20 min. All PET images were reconstructed with the maximum a posteriori (MAP) reconstruction algorithm in Inveon Acquisition Workspace (Siemens Medical Solutions Inc.) and analysed with Inveon Research Workspace 4.2 (Siemens Medical Solutions Inc.) after the coregistration of the PET/CT images. Regions of interest (ROIs) were drawn in the kidneys. The radioactivity density from image analysis is presented as the percent injected dose per gram (% ID/g). After the final imaging time point, the mice were sacrificed. The blood, brain, heart, lungs, liver, spleen, kidneys, stomach, colon and muscle were harvested for ex vivo biodistribution analysis. The radioactivity in each organ was measured with an automatic gamma counter (Perkin-Elmer) after which the organ weights were determined with a balance. The biodistribution is presented as a percent of the injected dose per gram (% ID/g)45 (link),46 (link).
Li S., Zhao Y., Zhang Y., Zhang Y., Zhang Z., Tang C., Weng L., Chen X., Zhang G, & Zhang H. (2021). The δ subunit of F1Fo-ATP synthase is required for pathogenicity of Candida albicans. Nature Communications, 12, 6041.
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Quantitative PET/CT Imaging Analysis

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All PET images were reconstructed with the maximum a posteriori (MAP) reconstruction algorithm in Inveon Acquisition Workspace (Siemens Medical Solutions Inc., USA) and analyzed with Inveon Research Workspace 4.2 (Siemens Medical Solutions Inc., USA) after the co-registration of PET/CT images. Regions of interest (ROIs) were drawn in the heart chamber for blood, whole brain, and liver. The time-activity curves (TAC) of blood, brain, and liver radioactivities at 0, 4, and 21 h were analyzed with Prism 8 (Graphpad). Blood TACs were fitted with one phase decay. Radioactivity density from image analysis is presented as percent injected dose per cubic centimeter (% ID/cc).
Seo J.W., Ingham E.S., Mahakian L., Tumbale S., Wu B., Aghevlian S., Shams S., Baikoghli M., Jain P., Ding X., Goeden N., Dobreva T., Flytzanis N.C., Chavez M., Singhal K., Leib R., James M.L., Segal D.J., Cheng R.H., Silva E.A., Gradinaru V, & Ferrara K.W. (2020). Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nature Communications, 11, 2102.
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3

PET Imaging and Quantification of Tumor Metabolism

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All PET images were reconstructed with the maximum a posteriori (MAP) reconstruction algorithm and analyzed with AsiPro software (Siemens Medical Solutions Inc., USA) and Inveon Research Workspace 4.2 (Siemens Medical Solutions Inc., USA). Regions of interest (ROIs) of bilateral tumors and blood were drawn after the co-registration of PET/CT images. To obtain the time-activity curve (TAC) of blood, blood radioactivity at 0 (30 min segmented to 6 frames), 5, and 24 h were fitted with one-phase decay curve with Prism 6 for Mac OS. Radioactivity density was presented as percent injected dose per cubic centimeter (%ID/cc)
Seo J.W., Tavaré R., Mahakian L.M., Silvestrini M.T., Tam S., Ingham E.S., Salazar F.B., Borowsky A.D., Wu A.M, & Ferrara K.W. (2018). CD8+ T-cell density imaging with 64Cu-labeled cys-diabody informs immunotherapy protocols. Clinical cancer research : an official journal of the American Association for Cancer Research, 24(20), 4976-4987.
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4

Comprehensive Multimodal Image Analysis

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Microscopic image process and ROI analyses were performed using ImageJ, LAS X (Leica) and SlidBook6 (3i). For PET/CT data and image processing, Inveon Acquisition Workspace (Siemens) and Inveon Research Workspace 4.2 (Siemens) was used, respectively. Microsoft Excel (ver. 16.35), and GraphPad Prism 8 for macOS were used for general data and statistical analysis. PyMOL 2.0 (Molecular Graphics System) was used to process the structure of capsid. FlowJo v10.1 (Treestar) was used for data analyses of results from flow cytometry. Gating/sorting strategy is presented at Supplementary Fig. 11 and reporting summary.
Seo J.W., Ingham E.S., Mahakian L., Tumbale S., Wu B., Aghevlian S., Shams S., Baikoghli M., Jain P., Ding X., Goeden N., Dobreva T., Flytzanis N.C., Chavez M., Singhal K., Leib R., James M.L., Segal D.J., Cheng R.H., Silva E.A., Gradinaru V, & Ferrara K.W. (2020). Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nature Communications, 11, 2102.
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5

In Vivo Bone Formation Evaluation

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hMSCs (1 × 106/cm3) were induced with osteoinduction medium for 7 days in vitro, embedded into 3D PCL scaffolds, followed by implanting subcutaneously into the dorsal surface of 8- to 10-week-old male non-obese diabetic (NSD) mice. The whole mice were subjected to in vivo micro-CT scanning after 4 or 8 weeks of implantation using Inveon hybrid microPET/CT scanner (Siemens). The region of interest (ROI) of the implanted scaffold was defined for analysis in Inveon Research workspace 4.2 (Siemens Healthineers). Mineralization was evaluated by calculating the volume and intensity of mineralized tissue in the ROI.
Chan N.T., Lee M.S., Wang Y., Galipeau J., Li W.J, & Xu W. (2022). CTR9 drives osteochondral lineage differentiation of human mesenchymal stem cells via epigenetic regulation of BMP-2 signaling. Science Advances, 8(46), eadc9222.
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