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Chondroitin 4 sulfate sodium salt

Manufactured by Merck Group
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Chondroitin 4-sulfate sodium salt is a chemical compound used in various laboratory applications. It is a naturally occurring sulfated glycosaminoglycan found in the extracellular matrix of various connective tissues. The compound is utilized in research and analysis, particularly in the fields of biochemistry and cell biology.

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Lab products found in correlation

Sodium hyaluronate, by Lifecore Biomedical (1 mentions) Lovastatin, by Merck Group (1 mentions) Acetonitrile, by Thermo Fisher Scientific (1 mentions) Methanol, by Thermo Fisher Scientific (1 mentions) Carboxymethylcellulose, by Merck Group (1 mentions) Milli q water purifier, by Merck Group (1 mentions) Rhodamine b isothiocyanate rbitc, by Merck Group (1 mentions) Phosphoric acid hplc grade, by Thermo Fisher Scientific (1 mentions) Chitosan, by Merck Group (1 mentions)

2 protocols using chondroitin 4 sulfate sodium salt

1

Hyaluronate and Chondroitin Sulfate Synthesis

Cited 1 time
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Sodium hyaluronate was
obtained from Lifecore Biomedical (82 kDa as measured with GPC, Chaska,
MN). Chondroitin 4-sulfate sodium salt (bovine trachea, lyophilized
powder suitable for cell culture, molecular weight 19.9 kDa as measured
previously34 (link)) was purchased from Sigma-Aldrich
(Zwijndrecht, the Netherlands). All other reagents were obtained from
either Sigma-Aldrich (Zwijndrecht, the Netherlands) or TCI Europe
N.V. and were used as received. All organic solvents were purchased
from Biosolve (Valkenswaard, the Netherlands) and used without further
purification.
Mihajlovic M., Rikkers M., Mihajlovic M., Viola M., Schuiringa G., Ilochonwu B.C., Masereeuw R., Vonk L., Malda J., Ito K, & Vermonden T. (2022). Viscoelastic Chondroitin Sulfate and Hyaluronic Acid Double-Network Hydrogels with Reversible Cross-Links. Biomacromolecules, 23(3), 1350-1365.
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2

Simvastatin-Chitosan Nanoparticles for Drug Delivery

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The simvastatin (SV) used in this study was a generous gift from the Riyadh Pharma Co., Saudi Arabia. Low-molecular-weight chitosan (viscosity 20,000 cps) (degree of deacetylation [DD] of 92%), chondroitin 4-sulfate sodium salt (ChS, sodium content 5.6% w/w, molecular weight 59 kDa), simvastatin hydroxy acid ammonium salt sodium (SVA), lovastatin, lovastatin hydroxy acid sodium salt, rhodamine B isothiocyanate (RBITC), and carboxymethylcellulose were purchased from Sigma Aldrich Chemical Co. Ltd. (St. Louis, MO, USA). Sodium tripolyphosphate (TPP) and glacial acetic acid were obtained from BDH Organic (Poole, Dorset, UK). Ethanol, methanol, acetonitrile, and phosphoric acid (HPLC grade) were obtained from Fisher Scientific Co., (Loughborough, UK). phosphate buffer solution (PBS) (pH 7.4) solution (8 g NaCl (137 mM), 0.2 g KCl (2.7 mM), 1.15 g Na2HPO4··7H2O (8.1 mM), and 0.2 g KH2PO4 (1.47 mM) in 1000 mL deionized water. Deionized water was obtained using a Milli-Q® water purifier (Millipore, France) and used throughout the study.
Faris T.M., Harisa G.I., Alanazi F.K., Samy A.M, & Nasr F.A. (2020). Developed simvastatin chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate for ASGPR-mediated targeted HCC delivery with enhanced oral bioavailability. Saudi Pharmaceutical Journal : SPJ, 28(12), 1851-1867.
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