Rabbit anti p rb

Manufactured by R&D Systems

Rabbit anti-P-Rb is an antibody that recognizes the phosphorylated form of the retinoblastoma protein (Rb). Rb is a key regulator of the cell cycle, and its phosphorylation status is important for the control of cell proliferation. This antibody can be used to detect the phosphorylated state of Rb in various cell and tissue samples.

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Lab products found in correlation

2 protocols using rabbit anti p rb

Targeting Survivin and mTOR Signaling

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Sources were: YM155, BEZ-235 (Selleck Chemicals); rabbit anti-Survivin IgG (#AF886) (R&D Systems); rabbit anti-P-Rb (S807/811, #9308), mouse anti-Cyclin D1 (#2926), rabbit anti-Mcl-1(#5453), rabbit anti-P-p70S6K1 (T389, #9205), rabbit anti-Raptor (#4978, #4972) rabbit anti-P-Raptor (S792, #2083), rabbit anit-HIF-1α (#3716), rabbit anti-HIF-2α (#7096), rabbit anti-VHL (#2738), rabbit anti-P-AMPKα (T172, #2535), rabbit anti-Cyclin D1 (sc-753), rabbit anti-Cyclin D2 (sc-593), mouse anti-P-rS6 (S240, sc-293143), mouse anti-rS6 (sc-74459), mouse anti-GAPDH (sc-51907), mouse anti-AMPK-α1 (39881) (Santa Cruz Biotechnologies, Inc.); mouse anti-β-actin (#A-5441), dimethyoxalylglycine (400091), deferoxamine mesylate (D9533) (Sigma-Aldrich, Inc.); DMEM/F12 (Media Tech); characterized fetal bovine serum (FBS) (HyClone); Roscovitine (LC labs).

Danielpour D., Corum S., Welford S.M, & Shankar E. (2021). Hypoxia represses early responses of prostate and renal cancer cells to YM155 independent of HIF-1α and HIF-2α. Current Research in Pharmacology and Drug Discovery, 3, 100076.

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Regulation of Survivin and Cell Cycle Proteins

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Sources were: YM155 (Selleck Chemicals); rabbit anti-Survivin IgG (#AF886) (R&D Systems); rabbit anti-P-Rb (S807/811, #9308), rabbit anti-P-Cyclin D1 (T286, #3300), mouse anti-Cyclin D1 (#2926), rabbit anti-Mcl-1(#5453), mouse anti-Cyclin D3 (#2936), rabbit anti-P-Akt (T308, #6955), rabbit anti-Akt (S473, #9271), rabbit anti-rS6 (#2217), rabbit anti-P-rS6 (S235/236, #2211), rabbit anti-P-p70S6K1 (T389, #9205), rabbit anti-mTOR (#2972), rabbit anti-P-mTOR (S2448, #2971), rabbit anti-Raptor (#4978, #4972) rabbit anti-P-Raptor (S792, #2083) rabbit anti-Rictor (#2140), rabbit anti-P-Rictor (T1135, #3806), rabbit anti-AMPKα (#5831), rabbit anti-P-AMPKα (T172, #2535) rabbit anti-AMPKα1 (#2795), rabbit anti-AMPKα2 (#2757), rabbit anti-4E-BP1 (#9644), rabbit anti-P-4E-BP1 (S65) (Cell Signaling Technologies); rabbit anti-Rb (sc-50), rabbit anti-Cyclin D1 (sc-753), rabbit anti-Cyclin D2 (sc-593), mouse anti-GAPDH (sc-51907), mouse anti-α-tubulin (sc-5386), mouse anti-P-rS6 (S240, sc-293143), mouse anti-rS6 (sc-74459), mouse anti-p70S6Kα (sc-39367) (Santa Cruz Biotechnologies, Inc.); mouse anti-β-actin (#A-5441), cycloheximide (CHX), actinomycin D (Act D), MG132, curcumin, (Sigma-Aldrich, Inc.); calyculin A, rapamycin and Compound C (LC labs, Inc.) DMEM/F12 (Media Tech); characterized fetal bovine serum (FBS) (HyClone).

Danielpour D., Gao Z., Zmina P.M., Shankar E., Shultes B.C., Jobava R., Welford S.M, & Hatzoglou M. (2019). Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK. Scientific Reports, 9, 11541.

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