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Memantine

Manufactured by MedChemExpress

Memantine is a chemical compound used as a laboratory tool for research purposes. It functions as an N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine is commonly utilized in various scientific investigations and experiments, but its specific intended use should not be extrapolated upon.

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2 protocols using memantine

1

Comparative Physicochemical Characterization

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In this study, 14 compounds with different physiochemical properties were selected. Antipyrine, ofloxacin, lamotrigine, digoxin, quinidine, atenolol, carbamazepine, propranolol, diltiazem, memantine, diphenhydramine, pyrilamine, and gabapentin were purchased from MedChemExpress (Monmouth Junction). Fexofenadine was purchased from Tokyo Chemical Industry. The other chemicals and reagents were of the HPLC grade or better.
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2

Investigating NMDA Receptor Signaling Pathways

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The antibodies for the related proteins were listed below: GRIN2D (Abclonal A10080, 1:1000, for western blot), GAPDH (cell signaling, 5174 S, 1:2000, for western blot), p-CREB (cell signaling, 9198, 1:1000, for western blot), t-CREB (cell signaling, 9197T, 1:1000, for western blot), HMGA2 (cell signaling, 8179, 1:1000, for western blot), t-p38 (cell signaling, 8690T, 1:1000, for western blot), p-p38 (cell signaling, 4511T, 1:1000, for western blot), t-JNK (Cell signaling, 9252T, 1:1000, for western blot), p-JNK (cell signaling, 4668T, for western blot), p-MSK (Cell signaling, 9595T,1:1000, for western blot), t-MSK (Mybiosource, MBS8204177, 1:1000, for western blot). GRIN2D (Mybiosource, MBS9605541, 1:500, for immunohistology). Fluo-3AM (Beyotime, S1056, 1:1000, for calcium measurement). Memantine (MedChemExpress, HY-B0365A). NMDA (MedChemExpress, HY-17,551).
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