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2 protocols using 2 ethyl 2 oxazoline

1

Synthesis of Fluorescent Poly(2-Ethyl-2-Oxazoline)

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Methyl p-toluenesulfonate, ethylenediamine, and super dehydrated acetonitrile were purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). 2-Ethyl-2-oxazoline was purchased from Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (WSC) was purchased from Dojindo Molecular Technologies, Inc. (Kumamoto, Japan). 4-Dimethylaminopyridine (DMAP) and 2 mol/l-hydrochloric acid were purchased from Nacalai Tesque, Inc. (Kyoto, Japan). Poly(2-Ethyl-2-oxazoline) (molecular weight: 25, 50, and 200 kDa) was purchased from Sigma-Aldrich Japan (Tokyo, Japan). 1H-Benz[e]indolium, 2-[7-[3-(5-carboxypentyl)-1,3-dihydro-1,1-dimethyl-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrien-1-yl]-1,1-dimethyl-3-(4-sulfobutyl), inner salt (ICCA) was synthesized according to previously reported method32 (link). All other chemicals of highest purity available were used.
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2

Radiopharmaceutical Synthesis Protocols

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Methyl p-toluenesulfonate, ethylenediamine, and super-dehydrated acetonitrile were purchased from Wako Pure Chemical Industries, Ltd. 2-ethyl-2-oxazoline, 2-isopropyl-2-oxazoline, and 2-propyl-2oxazoline were purchased from Tokyo Chemical Industry Co., Ltd. S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid (p-SCN-Bn-DOTA) was purchased from Macrocyclics Inc. 111 In chloride ( 111 InCl 3 ) was kindly supplied by Nihon Medi-Physics. 90 Y-chloride ( 90 YCl 3 ) was purchased from Eckert & Zieglr Radiopharma GmbH. Other reagents were of reagent grade and were used without further purification unless otherwise indicated.
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