Spss statistical analysis software version 20

The characteristics of the study group were expressed as median and interquartile range or number and frequency (%). Mann–Whitney U test (not normally distributed data) was employed for the comparison of TDD, C₀, and C₀/D with respect to the CYP3A5 genotype. In addition, Mann–Whitney U test was used to compare eGFR, Tac IPV, and C0/D between Tac formulation, whereas Chi square test was performed to compare the frequency of AR and presence of CYP3A5*1/*3 genotype. Linear regression analysis was performed to evaluate the potential influence of independent predictors on eGFR. All analyses were performed with SPSS statistical analysis software, version 20.0 (SPSS, Chicago, IL, United States) at the significance level set at p < 0.05. MATLAB R2017b (MathWorks) software was used to perform the MC simulation.

Descriptive statistics were used to summarize clinical characteristics of the study group. The Shapiro–Wilk test (p > 0.05, normal distribution of data assumed) and Q-Q plots were used to confirm the assumption of normal distribution. Numerical variables were expressed as the mean ± SD in case of normal distribution, median (interquartile range) if a variable did not follow normal distribution, and as a percentage for categorical data. If normal distribution was met, the one-way ANOVA with the Tukey correction was used for group comparisons; otherwise, the non-parametric Kruskal–Wallis test was applied. The Chi-squared test was used to compare categorical variables. The correlation between two quantitative variables was determined by Spearman’s correlation test. ROC analysis was used to determine AUC parameters and cut off values. A p-value below 0.05 was considered significant. All analyses were performed by means of the SPSS statistical analysis software, Version 20.0 (SPSS, Chicago, IL, USA).