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2 protocols using gabapentin

1

Comparative Physicochemical Characterization

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In this study, 14 compounds with different physiochemical properties were selected. Antipyrine, ofloxacin, lamotrigine, digoxin, quinidine, atenolol, carbamazepine, propranolol, diltiazem, memantine, diphenhydramine, pyrilamine, and gabapentin were purchased from MedChemExpress (Monmouth Junction). Fexofenadine was purchased from Tokyo Chemical Industry. The other chemicals and reagents were of the HPLC grade or better.
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2

Evaluating Small Molecule Interactions

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The following small molecules were used: cisplatin and Leu (Sigma-Aldrich), chloroquine (CQ), rapamycin, gabapentin, and 3-methyladenine (3-MA) (MedChemExpress, Princeton, NJ, USA), Ac-Leu-NH2 (BACHEM, Switzerland), BCAAs (Anhui BBCA Pharmaceuticals Co., Ltd., China). The cisplatin, CQ, gabapentin, 3-MA, Leu, Ac-Leu-NH2, and BCAAs were dissolved in phosphate buffer saline, and rapamycin was dissolved in dimethyl sulfoxide (Sigma-Aldrich).
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