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76 protocols using constellation vision system

1

Comprehensive Ophthalmic Surgical Protocol

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All surgeries were performed by two experienced surgeons (SK and HI). All patients received local anesthesia consisting of 4% lidocaine eye drops and sub-Tenon injection of ~4 mL of 2% lidocaine or 0.75% ropivacaine hydrochloride. General anesthesia was performed as necessary. Patients' skin and ocular surfaces were disinfected using 5% povidone-iodine and eight-fold diluted PA · IODO Ophthalmic and Eye washing Solution Disinfection (Nitten Pharmaceutical Co., Nagoya, Japan). The Constellation Vision System (Alcon Laboratories, Inc., Fort Worth, TX, USA) combined with a 27+ Combined Procedure Pak (Alcon Laboratories, Inc.) and a wide-angle non-contact viewing system (Resight 500 or 700, Carl Zeiss Meditec AG, Jena, Germany) were used for all surgeries. A 27G Oshima Vivid chandelier (Bausch and Lomb, St. Louis, MO) was utilized for illumination as needed. Combined cataract surgery, phacoemulsification, and intraocular lens implantation were performed using the Constellation Vision System (Alcon Laboratories) as needed. We routinely removed as much vitreous gel as possible irrespective of the purpose of the surgery.
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2

Phacoemulsification Technique for Cataract Surgery

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The method for cataract surgery was phacoemulsification using the Alcon Constellation Vision System device (Alcon Laboratories, Inc., Fort Worth, TX, USA). The procedure was performed for the right eyes by the same experienced surgeon under sterile conditions and topical anesthesia. After performing the corneal side incisions, main corneal tunnel and the capsulorhexis, the nucleus material was excreted by phacoemulsification. Following the aspiration of epinucleus and cortex, an aspheric foldable intraocular lens (IOL) was implanted into the capsular bag. The surgical procedure was completed after the injection of intracameral antibiotic and confirmation of adequate ACD with normal globe tonus. Topical ophthalmic steroids and antibiotics were prescribed for postoperative treatment. The patients had control visits at postoperative day 1, week 1, and month 1. Considerable peri- or postoperative complications were planned to be recorded, and fortunately no remarkable peri- or postoperative complications were observed. Topical moxifloxacin and prednisolone were prescribed 5 times a day for 2 weeks in the postoperative period.
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3

Vitreous Collection and Processing for Biomarker Analysis

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PPV was performed by five experienced vitreoretinal surgeons (H.T., K.S., T.K., K.S., and A.H.) at the Kyorin Eye Center. The surgical procedure was described previously [58 (link)]. Briefly, a 25-gauge vitrectomy system (Alcon Constellation® Vision System, Alcon Laboratories, Fort Worth, TX, USA) with a cutting rate of 5000 cuts/min and aspiration pressure of 650 mmHg was used. The lens was extracted from patients if the eye was phakic followed by phacoemulsification with simultaneous implantation of an intraocular lens. Before starting PPV, a 25G trocar was inserted 3.5 mm posterior to the corneal limbus by a transconjunctival one-step incision. The vitreous (0.5–2.0 mL) was collected before the infusion, and it was immediately centrifuged at 400× g (1500 rpm) for 10 min to remove any cell debris. All samples were preserved at −80 °C until assayed.
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4

Phacoemulsification Instrument Settings for Cortical-Capsular Cleavage

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To ensure that the irrigation dynamic pressure is sufficient for achieving an effective cortical-capsular cleavage, the phaco instrument settings for iH are very important. The two different phaco machines used in this study were: 1) the Constellation Vision System (Alcon Laboratories, Inc., Fort Worth, TX, USA), which contains a 0.9 mm diameter phaco tip with a micro-sleeve and 2) the Centurion Vision System (Alcon Laboratories, Inc.), which contains a 0.9 mm diameter phaco tip with an ultra-sleeve. The phacoemulsification parameters used by the Constellation Vision System included the following: vacuum system, Venturi pump; vacuum pressure, 200 mmHg; irrigation pressure, 60 cm H2O; and ultrasound power, 0. The phacoemulsification parameters used by the Centurion Vision System included the following: vacuum system, peristaltic pump; vacuum pressure, 350 mmHg; irrigation pressure, 36 mmHg; aspiration flow rate, 45 cc/min, and ultrasound power, 0.
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5

Brilliant Blue G-Guided ILM Peeling

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All surgeries were performed by two surgeons (F.O., Y.S.), using standard pars plana vitrectomy with 25 gauge probes (Alcon Constellation vision system) under sub-Tenon local anaesthesia. When a clinically significant cataract was observed, it was simultaneously operated. After inducing posterior vitreous detachment and performing core vitrectomy, we injected 0.2 ml of 0.025% brilliant blue G solution gently over the macula for 15 seconds and washed it out with an irrigation solution. Internal limiting membrane (ILM) peeling and fluid/air exchange were performed in all cases. For the next 1–3 days, the patients were instructed to maintain a face-down position8 (link).
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6

Vitreoretinal Surgery for Vitreous Hemorrhage

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All surgeries were performed by experienced vitreoretinal specialists. After retrobulbar block using a 4 ml mixture of 0.75% bupivacaine and 2% lidocaine in a 1 : 1 ratio, a standard three-port 23-gauge, or 25-gauge vitrectomy with a wide-angle, noncontact viewing system (Resight®; Carl Zeiss Meditec AG, Jena, Germany) was performed using the constellation vision system (Alcon Laboratories Inc., Fort Worth, TX, USA). For phakic eyes, combined surgery involving phacoemulsification and intraocular lens implantation was performed using the same machine before vitrectomy. During vitrectomy, thick vitreous blood around the vitreous cutting head and optical fiber was initially removed. Subsequently, the anterior and posterior vitreous cavities were removed. If necessary, triamcinolone acetonide was injected to mark the residual vitreous cortex. Using assisted scleral indentation, clear and meticulous shaving of the vitreous base was performed using a wide-angle viewing system. Next, the organized vitreoretinal bands as well as proliferative and neovascular membranes were carefully separated and resected. Hemostasis was achieved by raising the IOP or using endodiathermy. Laser photocoagulation was performed for ischemic areas or holes. At the end of surgery, a balanced salt solution, air, or silicone oil was used to fill the vitreous cavity, as appropriate.
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7

Surgical Interventions for Retinal Detachment

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On the basis of the surgeon’s judgment, each patient underwent PPV or SB. PPV involved a 25-gauge transconjunctival microincision and was performed using the Constellation Vision System (Alcon Laboratories, Inc., Fort Worth, TX, USA). The vitreous traction around the retinal breaks was released and the SRF was drained from a posterior drainage retinotomy. Then, fluid-20% sulfur hexafluoride gas exchange and endolaser photocoagulation of the retinal breaks and intentional retinal hole were performed. The epiretinal membrane or internal limiting membrane were not peeled. Patients over 50 years old also underwent simultaneous cataract extraction with posterior chamber intraocular lens implantation19 (link).When SB was performed, chorioretinal adhesions were created with cryopexy around the retinal breaks. A silicone explant was used to close the peripheral retinal breaks, and external drainage of SRF was performed when necessary. No patients were administered intravitreal injections of gas.
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8

Intracameral Dexamethasone Injection for Post-PPV

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All patients underwent 25-gauge PPV surgery using the Constellation Vision System (Alcon Laboratories, Fort Worth, Texas, USA). None of the cases required use of triamcinolone acetonide for visualisation. All cases and controls were first time vitrectomies and the surgeries were completed in under 1 hour. At the conclusion of vitreoretinal surgery for the test cases, the surgeon created a corneal paracentesis using a 15° blade and injected the dexamethasone suspension as a single 5 μL droplet by intracameral injection into the anterior chamber using a 28-gauge cannula. The ophthalmic surgeon monitored the status and placement of the drug delivery. The control groups were prescribed topical prednisolone acetate and did not receive any intracameral injection at the end of surgery. All patients received topical moxifloxacin 0.5% (Lupin Pharmaceuticals, Baltimore, Maryland, USA) four times per day for 1 week starting POD 1. No cycloplegics or topical NSAIDs were prescribed for any patient postoperatively.
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9

Silicone Oil Removal After 23G Vitrectomy

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This is a retrospective, interventional study, evaluating consecutive cases that underwent SIO removal after primary 23G vitrectomy for complex retinal detachments. All cases were operated by the same surgeon using local anesthesia. Alcon CONSTELLATION® Vision System was used at both primary vitrectomy and later on to actively remove the silicone oil. Oxane 5700 silicone oil was used for endotamponade in all cases.
The anatomical result was the main followed parameter. Intra and postoperative complications and also intraocular pressure changes were evaluated. Cases were followed-up for at least 12 months.
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10

Vitrectomy with Subretinal Fluid Drainage

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For vitrectomy, total vitrectomy was performed using the 25-gauge (Constellation® vision system, Alcon® Laboratories, Inc.) and then was followed by internal subretinal fluid drainage through fluid-air exchange and laser photocoagulation applied around retinal tears. Fluid-gas exchange (C3F8 or SF6) was performed on all eyes. If there was clinically significant lens opacity preoperatively, phacoemulsification and intraocular lens implantation were performed. All surgeries were performed by only one vitreoretinal surgeon (YHL).
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