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Cobas mira plus bio analyzer

Manufactured by Roche
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The Cobas Mira Plus Bio-analyzer is an automated clinical chemistry analyzer designed for in vitro diagnostic testing. It is capable of performing a variety of routine clinical chemistry assays. The instrument provides automated sample handling, reagent management, and data processing capabilities to support efficient laboratory workflows.

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Lab products found in correlation

Microparticle enzyme immunoassay, by Abbott (3 mentions) Hepcidin 25 human eia kit, by Bachem (3 mentions)

Spelling variants of this product

Cobas Mira Plus (115 citations) Cobas Mira (115 citations) Cobas analyzer (113 citations) Cobas Mira analyzer (20 citations) Cobas Mira Plus analyzer (14 citations) Mira Plus (6 citations) Cobas-Bio (3 citations)

3 protocols using cobas mira plus bio analyzer

1

Cross-Sectional Study of Malaria, Anemia, and Hepcidin in Gambian Children

Cited 2 times
Check if the same lab product or an alternative is used in the 5 most similar protocols
All children aged 2–6 years old were recruited from ten rural villages in the West Kiang region of The Gambia during the malaria season (July to August 2001)42 (link). We used cross-sectional data collected at the start of the malaria season. All children had a clinical examination, anthropometric measurements and a 3-d course of mebendazole for possible hookworm infection. A blood sample was collected for complete blood count, observations with a malaria slide, measurements of ferritin (Microparticle Enzyme Immunoassay (Abbott Architect)), hepcidin (Hepcidin-25 (human) EIA Kit (Bachem) and ACT (immunoturbidimetry, Cobas Mira Plus Bio-analyzer, Roche) levels and DNA extraction. Children with a temperature >37.5°C had a malaria blood film, appropriate clinical treatment and a blood sample 2 weeks later after recovery from illness. Genotyping of sickle cell was performed on amplified DNA as detailed elsewhere42 (link). The Gambian Bachem hepcidin values were harmonized by converting to the old DRG hepcidin assay values ((0.266×Bachem values)+1.633) and then to the new High Sensitive DRG hepcidin assay values ((1.989× old DRG values)-3.24) as previously validated43 (link).
Muriuki J.M., Mentzer A.J., Mitchell R., Webb E.L., Etyang A.O., Kyobutungi C., Morovat A., Kimita W., Ndungu F.M., Macharia A.W., Ngetsa C.J., Makale J., Lule S.A., Musani S.K., Raffield L.M., Cutland C.L., Sirima S.B., Diarra A., Tiono A.B., Fried M., Gwamaka M., Seth A.A., Wirth J.P., Wegmüller R., Madhi S.A., Snow R.W., Hill A.V., Rockett K.A., Sandhu M.S., Kwiatkowski D.P., Prentice A.M., Byrd K.A., Ndjebayi A., Stewart C.P., Engle-Stone R., Green T.J., Karakochuk C.D., Suchdev P.S., Bejon P., Duffy P.E., Smith G.D., Elliott A.M., Williams T.N, & Atkinson S.H. (2021). Malaria is a cause of iron deficiency in African children. Nature medicine, 27(4), 653-658.
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2

Comprehensive Hematological Biomarker Profiling

Check if the same lab product or an alternative is used in the 5 most similar protocols
Haemoglobin (Medonic CA 530 Haemoglobinometer) and zinc protoporphyrin (ZnPP) levels (Aviv Biomedical Hematoflurometer) were measured within 24 hours of sample collection. Hepcidin (Hepcidin-25 [human] EIA kit; Bachem), ferritin (IMx ferritin assay, Microparticle Enzyme Immunoassay; Abbot Laboratories), soluble transferrin receptor (sTfR, Human sTfR ELISA; R&D Systems), serum iron, unsaturated iron binding capacity (UIBC, Ferrozine-based photometry and colorimetry; Hitachi 911 automated analyzer), and α
1-antichymotrypsin (ACT, immunoturbidimetry, Cobas Mira Plus Bioanalyzer, Roche) were assayed according to the manufacturers’ instructions from plasma samples stored at -80°C. Transferrin saturation (TSAT) was calculated from plasma iron and UIBC (TSAT = [plasma iron/ (UIBC + plasma iron)] X 100)
27 (link). Hepcidin/ferritin and TSAT/hepcidin ratios were also calculated
28 (link). Giemsa-stained thick and thin blood films were examined for
Plasmodium falciparum and other
Plasmodium species at the start and end of the malaria season.
Abuga K.M., Rockett K.A., Muriuki J.M., Koch O., Nairz M., Sirugo G., Bejon P., Kwiatkowski D.P., Prentice A.M, & Atkinson S.H. (2020). Interferon-gamma polymorphisms and risk of iron deficiency and anaemia in Gambian children. Wellcome Open Research, 5, 40.
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3

Cross-Sectional Study of Malaria, Anemia, and Hepcidin in Gambian Children

Cited 2 times
Check if the same lab product or an alternative is used in the 5 most similar protocols
All children aged 2–6 years old were recruited from ten rural villages in the West Kiang region of The Gambia during the malaria season (July to August 2001)42 (link). We used cross-sectional data collected at the start of the malaria season. All children had a clinical examination, anthropometric measurements and a 3-d course of mebendazole for possible hookworm infection. A blood sample was collected for complete blood count, observations with a malaria slide, measurements of ferritin (Microparticle Enzyme Immunoassay (Abbott Architect)), hepcidin (Hepcidin-25 (human) EIA Kit (Bachem) and ACT (immunoturbidimetry, Cobas Mira Plus Bio-analyzer, Roche) levels and DNA extraction. Children with a temperature >37.5°C had a malaria blood film, appropriate clinical treatment and a blood sample 2 weeks later after recovery from illness. Genotyping of sickle cell was performed on amplified DNA as detailed elsewhere42 (link). The Gambian Bachem hepcidin values were harmonized by converting to the old DRG hepcidin assay values ((0.266×Bachem values)+1.633) and then to the new High Sensitive DRG hepcidin assay values ((1.989× old DRG values)-3.24) as previously validated43 (link).
Muriuki J.M., Mentzer A.J., Mitchell R., Webb E.L., Etyang A.O., Kyobutungi C., Morovat A., Kimita W., Ndungu F.M., Macharia A.W., Ngetsa C.J., Makale J., Lule S.A., Musani S.K., Raffield L.M., Cutland C.L., Sirima S.B., Diarra A., Tiono A.B., Fried M., Gwamaka M., Seth A.A., Wirth J.P., Wegmüller R., Madhi S.A., Snow R.W., Hill A.V., Rockett K.A., Sandhu M.S., Kwiatkowski D.P., Prentice A.M., Byrd K.A., Ndjebayi A., Stewart C.P., Engle-Stone R., Green T.J., Karakochuk C.D., Suchdev P.S., Bejon P., Duffy P.E., Smith G.D., Elliott A.M., Williams T.N, & Atkinson S.H. (2021). Malaria is a cause of iron deficiency in African children. Nature medicine, 27(4), 653-658.
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