Wild type w1118

Manufactured by Bloomington Drosophila Stock Center

Sourced in United States, France

The wild type w1118 is a common fruit fly (Drosophila melanogaster) strain used in research. It is a widely utilized control strain with a white eye phenotype. The w1118 strain serves as a standard reference point for various genetic and molecular studies conducted with Drosophila.

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Lab products found in correlation

Uas α syn, by Bloomington Drosophila Stock Center (1 mentions) Th gal4, by Bloomington Drosophila Stock Center (1 mentions) Fmr1het mice, by Jackson ImmunoResearch (1 mentions)

Spelling variants of this product

W1118 (165 citations) Wild type (w1118 stock #5905) (2 citations) Wild-type w1118 flies (2 citations) Wild-type isogenic w1118 strain (2 citations)

3 protocols using wild type w1118

Drosophila Larval Strains for Neuroscience

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Flies were raised on standard cornmeal and molasses medium at 25^°C. Drosophila melanogaster male 3rd instar larvae of the following strains were used for experiments:
Wildtype: w¹¹¹⁸ [Bloomington Drosophila Stock Center (BDSC), Bloomington, IN, United States]. unc-13^GFSTF: y[1] w[*]; Mi{PT-GFSTF.0}unc-13[MI00468-GFSTF.0] (stock sent out to BDSC). Original MiMIC-strain (MI00468): y[1] w[*]; Mi{y[+ mDint2] = MIC}unc-13[MI00468]/In(4)ci[D], ci[D] pan[ciD] (BDSC #31015).

Dannhäuser S., Mrestani A., Gundelach F., Pauli M., Komma F., Kollmannsberger P., Sauer M., Heckmann M, & Paul M.M. (2022). Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation. Frontiers in Cellular Neuroscience, 16, 1074304.

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Drosophila Model of Parkinson's Disease

Cited 1 time

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Flies were grown in standard cornmeal/agar media with 0.4% propionic acid on a 12-hour light/dark cycle at 25°C. Fly strains used were: wild type w1118 (from Bloomington Stock Center), TH-Gal4 (a kind gift from Dr S. Birman at ESPCI, France) [18 (link)], UAS-α-Syn (A53T) (A53T, a gift from Dr. L. Pallanck, University of Washington, USA) [19 (link)]. In this study, we used a fly line carrying TH-Gal4 and UAS-α-Syn (A53T) on chromosome 3, designated as A53T. Flies were allowed to lay eggs onto an agar plate for an hour. Each plate had roughly 50 eggs on its surface. The plate was then incubated at 25°C for locomotion assay.

Blosser J.A., Podolsky E, & Lee D. (2020). L-DOPA-Induced Dyskinesia in a Genetic Drosophila Model of Parkinson’s Disease. Experimental Neurobiology, 29(4), 273-284.

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Generating Fmr1 and Centg1 Mutant Mice and Flies

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Mice were generated by crossing female Fmr1^HET mice (The Jackson Laboratory) with male Centg1 heterozygous mice (Chan et al., 2010 (link)), and were genotyped by PCR. The animal protocol was approved by the Institutional Animal Care and Use Committees of Emory University, UT Southwestern, NYU and CCHMC, and complied with the Guide for the Care and Use of Laboratory Animals. Flies were maintained at 25°C under standard conditions. Wild type Oregon-R, wild type w1118 (for behavioral analyses), dFmr1 (dFmr1^Δ50M/TM6B) (Zhang et al., 2001 (link)) and CenG1A (CenG1A^EY01217/CyO) alleles were obtained from the Bloomington Drosophila Stock Center. For details, see Supplemental Experimental Procedures.

Gross C., Chang C.W., Kelly S.M., Bhattacharya A., McBride S.M., Danielson S.W., Jiang M.Q., Chan C.B., Ye K., Gibson J.R., Klann E., Jongens T.A., Moberg K.H., Huber K.M, & Bassell G.J. (2015). Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in Fragile X syndrome. Cell reports, 11(5), 727-736.

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