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B6 cg thy1a cy tg tcratcrb 8rest j pmel 1

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B6.Cg-Thy1a/Cy Tg (TcraTcrb)8Rest/J (Pmel-1) is a transgenic mouse strain that expresses the T cell receptor (TCR) chains from the Pmel-1 T cell clone, which recognizes the melanoma-associated antigen gp100. This mouse strain is commonly used in research related to melanoma and immune responses.

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Lab products found in correlation

B6.129s1 cd36tm1mfe j, by Jackson ImmunoResearch (1 mentions) C57bl 6 female, by Charles River Laboratories (1 mentions) C57bl 6 tg tcratcrb 1100mjb j ot 1, by Jackson ImmunoResearch (1 mentions) Apoe b6.129p2 apoetm1unc j, by Jackson ImmunoResearch (1 mentions)

Spelling variants of this product

B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J (27 citations) Pmel-1 (7 citations) B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J (Pmel), (4 citations) B6.Cg Thy1a-Tg(TcraTcrb)8Rest/J (4 citations) B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest) (2 citations) Pmel-1/Thy1.1 mice (B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J), (2 citations)

3 protocols using b6 cg thy1a cy tg tcratcrb 8rest j pmel 1

1

Mice Strains for Immunological Research

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B6 mice were purchased from the National Cancer Institute. B6.Cg-Thy1a/Cy Tg (TcraTcrb)8Rest/J (Pmel-1) and B6.129S1-Cd36tm1Mfe/J (CD36−/−) mice were purchased from the Jackson Laboratory. CD36−/− Pmel mice were generated by crossing Pmel-1 mice with CD36−/− mice. All experiments complied with protocols approved by the Institutional Animal Care and Use Committee at the Houston Methodist Research Institute.
Ma X., Xiao L., Liu L., Ye L., Su P., Bi E., Wang Q., Yang M., Qian J, & Yi Q. (2021). CD36-mediated ferroptosis dampens intratumoral CD8+ T-cell effector function and impairs their antitumor ability. Cell metabolism, 33(5), 1001-1012.e5.
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Transgenic Mouse Model for T Cell Biology

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Animal care and experimental procedures were performed in accordance with Swedish guidelines and regulations after approval from the local ethical committee. C57BL/6-Tg(TcraTcrb)1100Mjb/J (OT-I, The Jackson Laboratory), B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J (pmel-1, The Jackson Laboratory), and B6.129S(C)-BATF3tm1Kmm (BATF3 KO, The Jackson Laboratory) mice were bred in-house and C57BL/6 females aged 6-10 weeks were purchased from Charles River. NOD-Prkdcscid-IL2rgTm1/Rj (NXG) females aged 6-7 weeks were purchased from Janvier. All mice were kept under a fixed 12-hour light/dark cycle with free access to food and water.
Zimmermannova O., Ferreira A.G., Ascic E., Santiago M.V., Kurochkin I., Hansen M., Met Ö., Caiado I., Shapiro I.E., Michaux J., Humbert M., Soto-Cabrera D., Benonisson H., Silvério-Alves R., Gomez-Jimenez D., Bernardo C., Bauden M., Andersson R., Höglund M., Miharada K., Nakamura Y., Hugues S., Greiff L., Lindstedt M., Rosa F.F., Pires C.F., Bassani-Sternberg M., Svane I.M, & Pereira C.F. (2023). Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science immunology, 8(85), eadd4817.
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Genetically modified mouse models

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C57BL/6 mice were purchased from the National Cancer Institute. B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J (Pmel-1), B6.129P2-Apoetm1Unc/J (Apoe−/−), and B6.129S6-Nr1h3tm1Djm/J (Lxra−/−) were purchased from the Jackson Laboratory. Pmel-1-Il9−/− mice and Pmel-1-Il9r−/− mice were produced by crossing Pmel-1 mice with Il9−/− mice or Il9r−/− mice. All experiments complied with protocols approved by the Institutional Animal Care and Use Committee at the Cleveland Clinic.
Ma X., Bi E., Huang C., Lu Y., Xue G., Guo X., Wang A., Yang M., Qian J., Dong C, & Yi Q. (2018). Cholesterol negatively regulates IL-9–producing CD8+ T cell differentiation and antitumor activity. The Journal of Experimental Medicine, 215(6), 1555-1569.
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