19f nmr spectra

All chemicals were provided by Enamine Ltd. (www.enamine.net). All solvents were treated according to standard methods. All reactions were monitored by thin-layer chromatography (TLC) and were visualized using UV light. Product purification was performed using silica gel column chromatography. TLC characterization was performed with precoated silica gel GF254 (0.2 mm), while column chromatography characterization was performed with silica gel (100-200 mesh). ¹H NMR spectra were recorded at 400, 500, or 600 MHz (Varian); ¹⁹ F NMR spectra were recorded at 376 MHz (Varian); and ¹³ C NMR spectra were recorded at 100, 126, or 151 MHz (Varian). ¹H NMR chemical shifts are calibrated using residual undeuterated solvents CHCl3 (δ = 7.26 ppm) or DMSO (δ = 2.50 ppm). ¹³ C NMR chemical shifts for ¹³ C NMR are reported relative to the central CHCl3 (δ = 77.16 ppm) or DMSO (δ = 39.52 ppm). ¹⁹ F NMR chemical shifts are calibrated using CFCl₃ as an internal standard. Coupling constants are given in Hz. High-resolution mass spectra (HRMS) were recorded on an Agilent LC/MSD TOF mass spectrometer by electrospray ionization time-of-flight reflectron experiments.