The following drugs were used: bradykinin, diethylamine NONOate (DEA NONOate), diltiazem, 5-hydroxytryptamine (5-HT), levcromakalim, nitro-l-arginine (NLA), and NS1619 (Sigma Chemical, St. Louis, MO); BMS 191011, and iberiotoxin, (Tocris, Ellisville, MO); apelin-13, and F13A (H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala-OH trifluoroacetate salt) (Bachem, Torrance, CA). Drug solutions were prepared fresh daily, kept on ice, and protected from light until used. All drugs were dissolved in double-distilled water with the exception of BMS 191011 and NS1619, which were dissolved initially in DMSO prior to further dilution in double-distilled water. Drugs were added to the myograph chambers in volumes not greater than 0.02 ml. Drug concentrations are reported as final molar concentrations in the myograph chamber.
Bms 191011
Manufactured by Bio-Techne
Sourced in United Kingdom
BMS-191011 is a small molecule compound produced by Bio-Techne. It functions as a selective inhibitor. Detailed information on its specific applications is not available.
Automatically generated - may contain errors
Lab products found in correlation
Ns11021, by Bio-Techne (2 mentions)
Iberiotoxin, by Bio-Techne (1 mentions)
Levcromakalim, by Merck Group (1 mentions)
L nitro arginine, by Merck Group (1 mentions)
Ns1619, by Merck Group (1 mentions)
Streptozotocin (stz), by Nacalai Tesque (1 mentions)
Tetrodotoxin, by Nacalai Tesque (1 mentions)
Pentobarbital sodium, by Nacalai Tesque (1 mentions)
Methoxamine hydrochloride, by Merck Group (1 mentions)
Fluorescein sodium salt, by Merck Group (1 mentions)
L arginine, by Nacalai Tesque (1 mentions)
Pontamine sky blue 6b, by Tokyo Chemical Industry (1 mentions)
Acetylcholine, by Merck Group (1 mentions)
4 protocols using bms 191011
1
Pharmacological Modulation of Vascular Tone
2
In Vitro and In Vivo Evaluation of BMS-191011 and NS11021 in TNBC
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BMS-191011 (Tocris) and NS11021 (Tocris) were prepared in 10 mM DMSO stock. The working concentrations of 10-50 μM contained 1-5 μl of DMSO in 1 mL DMEM medium, resulting in 0.1–0.5% of DMSO, which did not affect TNBC cells (Fig. S7 ). For testing in vivo effects of MDA-MD-231, 3 μl of 10 mM (equivalent to 186.82 ng) stock was added to 1 mL PBS, 50 μl was administrated directly into the xenograft grown in mouse via during day time in the animal imaging facility. For testing adverse effects of the drug, tail-vein injection was used.
3
Reagents for Neurotransmitter Research
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Acetylcholine, fluorescein sodium salt, and methoxamine hydrochloride were purchased from Sigma-Aldrich (St. Louis, MO, USA). BMS-191011 was purchased from Tocris Bioscience (Bristol, United Kingdom). Pontamine sky blue 6B was purchased from Tokyo Chemical Industry (Tokyo, Japan). L-Arginine, pentobarbital sodium, streptozotocin, and tetrodotoxin were purchased from Nacalai Tesque (Kyoto, Japan). Hydroxyethyl cellulose (Scopisol 15®) was purchased from Senju Pharmaceutical (Osaka, Japan). L-Citrulline was provided by KYOWA HAKKO BIO CO., LTD (Tokyo, Japan).
4
In Vivo Evaluation of BMS-191011 and NS11021 in TNBC
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BMS-191011 (Tocris) and NS11021 (Tocris) were prepared in 10mM DMSO stock. The working concentrations of 10-50mM contained 1-5ml of DMSO in 1 mL DMEM medium, resulting in 0.1-0.5% of DMSO, which did not affect TNBC cells (Figure S7). For testing in vivo effects of MDA-MD-231, 3ml of 10mM (equivalent to 186.82ng) stock was added to 1mL PBS, 50ml was administrated directly into the xenograft grown in mouse via during day time in the animal imaging facility. For testing adverse effects of the drug, tail-vein injection was used.
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