Sra737

Manufactured by Merck Group

Sourced in United States

SRA737 is a laboratory equipment product developed by Merck Group. It is designed to perform essential functions within a laboratory setting. The core function of SRA737 is to facilitate specific laboratory procedures, but a more detailed description cannot be provided while maintaining an unbiased and factual approach.

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Lab products found in correlation

Cell counting kit 8 kit, by Beyotime (1 mentions) 2 7 dichlorodihydrofluorescein diacetate dcfh da, by Thermo Fisher Scientific (1 mentions) Calcein am pi double staining kit, by Yeasen (1 mentions) Hoechst 33258, by Thermo Fisher Scientific (1 mentions) Olaparib, by Merck Group (1 mentions) Prexasertib, by Merck Group (1 mentions) Prexasertib, by Selleck Chemicals (1 mentions) Sra 737, by Selleck Chemicals (1 mentions) Olaparib, by Selleck Chemicals (1 mentions)

2 protocols using sra737

Multifunctional Nanoparticle Drug Delivery System

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1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol (Chol), 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (P-lyso PC), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2000) were provided by Xi’an Ruixi Biological Technology Co., Ltd. (Xi’an, China). Purpurin 18 (Pp18) was supplied by Xianhui Pharmaceutical Co., Ltd. (Shanghai, China). 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and 4-(dimethylamino) pyridine (DMAP) were acquired from Aladdin (Shanghai, China). DOX and SRA737 were purchased from Sigma-Aldrich (St. Louis, MO, USA) and MedChemExpress (Monmouth Junction, NJ, USA), respectively. 2,7-Dichlorodihydrofluorescein diacetate (DCFH-DA) and Hoechst 33,258 were purchased from Invitrogen (Carlsbad, CA, USA). Calcein-AM/PI Double Staining Kit was provided by Yeasen (Shanghai, China). Cell Counting Kit-8 kit (CCK-8) was supplied by Beyotime (Shanghai, China).

Feng X., Wu C., Yang W., Wu J, & Wang P. (2022). Mechanism-Based Sonodynamic–Chemo Combinations against Triple-Negative Breast Cancer. International Journal of Molecular Sciences, 23(14), 7981.

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Preparation of Drugs for In Vitro and In Vivo Studies

Cited 2 times

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For in vitro assays, olaparib (#S1060), prexasertib (#S7178), and SRA737 (CCT245737, #S8253) were purchased from Selleck Chemicals. olaparib (100 μM) and 10 μM prexasertib and SRA737 were prepared as stocks in dimethyl sulfoxide (DMSO; #S-002-M, Sigma-Aldrich). All drugs were stored in aliquots at −80°C until use. For in vivo studies, prexasertib mesylate hydrate (prexasertib; #1234015–57-6, InvivoChem LLC) was prepared in 20% CAPTISOL (CyDex Pharmaceuticals Inc.,), whereas olaparib (#V300, InvivoChem LLC) was formulated in phosphate-buffered saline (PBS) containing 10% DMSO and 10% (w/v) 2-hydroxy-propyl-β-cyclodextrin as described previously (18 (link), 58 (link)).

Gupta N., Huang T.T., Nair J.R., An D., Zurcher G., Lampert E.J., McCoy A., Cimino-Mathews A., Swisher E.M., Radke M.R., Lockwood C.M., Reichel J.B., Chiang C.Y., Wilson K.M., Chih-Chien Cheng K., Nousome D, & Lee J.M. (2023). BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA-mutant ovarian cancer. Science translational medicine, 15(701), eadd7872.

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