3t discovery

Manufactured by GE Healthcare

Sourced in Germany

The 3T Discovery is a magnetic resonance imaging (MRI) system manufactured by GE Healthcare. It is designed to provide high-quality, 3-tesla (3T) magnetic field strength imaging for various medical applications. The 3T Discovery offers advanced imaging capabilities and is suitable for a wide range of clinical and research purposes.

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Lab products found in correlation

Skyra 3t, by Siemens (3 mentions) Aera 1.5t, by Siemens (2 mentions) Signa 1.5t, by GE Healthcare (2 mentions) 3t intera, by Philips (1 mentions) Excite hdxt 1.5t, by GE Healthcare (1 mentions) 1.5 t espree, by Siemens (1 mentions)

Close spelling variants of this product

Discovery MR750 3T MR system Discovery MR750 3T MRI scanner 3T Discovery 750× scanner Discovery MR750 3T MRI system GE 3T Discovery MR750 scanner GE 3T Discovery 750× scanners GE 3T Discovery MR750w Discovery 3T GE-MR750 Discovery MR750w 3T 3T Discovery MR750w scanner

8 protocols using 3t discovery

Quantifying Brain Perfusion with ASL MRI

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Patient examinations were performed from December 2015 to April 2021 on 3T Discovery (GE Healthcare, Milwaukee, Wisconsin) scanners.
ASL acquisition: ASL was performed using a single-delay pseudocontinuous (pCASL), with 3D eight-stacked spiral fast spin echo readout acquisition with background suppression, with the following imaging parameters: TR: 6512, TE: 10.2, FOV: 24 x 24 cm, slice thickness: 4 mm, scan time: 4 min, labeling duration: 1,500 ms, post-label delay: 2,000 ms, background suppressed three averages per acquisition based on the previously mentioned acquisition time. M0 scans were also acquired. ASL was reconstructed with an interpolated resolution of 1.9 × 1.9 × 4 mm³.
ASL post-processing: ASL post-processing was performed prior to CBF quantification for motion correction.
For generating CBF quantification maps, the previously described one compartment model for standard single delay ASL was utilized in this study (19 (link), 20 (link)).

Yedavalli V.S., Hamam O., Bahouth M., Urrutia V.C., Ahmed A., Lu H., Jones C., Luna L.P., Sair H.I, & Lanzman B. (2022). Arterial Spin Labeling Imaging Characteristics of Anti-leucine-rich Glioma-Inactivated 1 Encephalitis: A Qualitative and Quantitative Analysis. Frontiers in Neurology, 13, 850029.

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Standardized mpMRI-Guided Prostate Biopsy Protocol

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mpMRI and biopsy of the prostate followed a standardized protocol. mpMRI exams were performed on 3T magnets [3T Discovery (GE, Waukesha, WI), MR Magnetom Trio or Skyra (Siemens, Erlagen, Germany)], in accordance with the Prostate Imaging-Reporting and Data System (PIRADS) recommendations. mpMRI was acquired within three months of prostate biopsy and interpreted by one of three fellowship trained radiologists using the most current version of PIRADS at that time. The prostate and any PIRADS 3 or higher regions of suspicion were outlined in Dynacad (InVivo, Gainsville, FL). mpMRI targeted biopsy of the prostate was conducted using a trans-rectal mpMRI-ultrasound fusion platform UroNav (InVivo, Gainsville, FL) with 2 cores taken per target. For MAST patients an additional 12 core extended template biopsy of the prostate was performed. For the BLaStM trial only the suspicious lesions were targeted during fiducial marker placement. All biopsy cores were interpreted by a single pathologist (ONK) with fellowship training in genitourinary pathology.

Punnen S., Stoyanova R., Kwon D., Reis I.M., Soodana-Prakash N., Ritch C.R., Nahar B., Gonzalgo M.L., Kava B., Liu Y., Arora H., Gaston S.M., Acosta R.P., Pra A.D., Abramowitz M., Kryvenko O.N., Davicioni E., Pollack A, & Parekh D.J. (2020). HETEROGENEITY IN GENOMIC RISK ASSESSMENT FROM TISSUE BASED PROGNOSTIC SIGNATURES USED IN THE BIOPSY SETTING AND THE IMPACT OF MRI TARGETED BIOPSY. The Journal of urology, 205(5), 1344-1351.

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Fronto-Parietal Cortex Electrode Implantation

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An electrode array of 36 circular platinum contacts (AdTech, 6 × 6 electrodes, 2.3 mm exposed diameter, 10 mm inter-electrode distance) embedded in a silastic sheet was surgically placed over the fronto-parietal region, including the sensorimotor cortex (Fig. 1A). Electrodes were localized using a high-resolution CT-scan and projected (Hermes et al., 2010 (link)) onto a cortical surface rendering generated from the preoperative anatomical T1 weighted MRI scan (GE 3T Discovery). During recording, all electrodes were referenced to an inactive subgaleal electrode with the recording surface facing away from the brain. The signals were amplified and digitalized at 2048 Hz. Upon inspection of the electrode signals, two channels that contained severe noise were excluded from analysis.

van den Boom M., Miller K.J., Gregg N.M., Ojeda Valencia G., Lee K.H., Richner T.J., Ramsey N.F., Worrell G.A, & Hermes D. (2021). Typical somatomotor physiology of the hand is preserved in a patient with an amputated arm: An ECoG case study. NeuroImage : Clinical, 31, 102728.

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Cortical Electrode Array Placement

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An electrode array of 36 circular platinum contacts (AdTech, 6 x 6 electrodes, 2.3 mm exposed diameter, 10mm inter-electrode distance) embedded in a silastic sheet was surgically placed over the fronto-parietal region, including the sensorimotor cortex (Figure 1A). Electrodes were localized using a high-resolution CT-scan and projected (Hermes et al. 2010 ) onto a cortical surface rendering generated from the preoperative anatomical T1 weighted MRI scan (GE 3T Discovery). During recording, all electrodes were referenced to an inactive subgaleal electrode with the recording surface facing away from the brain. The signals were amplified and digitalized at 2048 Hz. Upon inspection of the electrode signals, two channels that contained severe noise were excluded from analysis.

Boom M.v.d., Miller K.J., Gregg N.M., Ojeda G.R., Lee K.H., Richner T.J., Ramsey N.F., Worrell G.A., & Hermes D. (2021). Typical somatomotor physiology of the hand is preserved in a patient with an amputated arm.

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Standardized Brain Tumor MRI Protocol

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MR imaging was obtained using seven MRI scanners (2 Skyra 3T and 2 Aera 1.5T from Siemens Healthineers, Erlangen Germany; 2 Signa 1.5T and one Discovery 3T from GE Healthcare, Waukesha, WI) within our Radiology Department. Image acquisition was performed using a standardized preoperative brain tumor MRI protocol within our radiology department, including: FLAIR (TR/TE/TI, 8000–12,000/98–130/2400–2700 ms, voxel size: 0.5 × 0.5 × 1 mm³), DWI (TR/TE: 4025-4600/65-82 ms, with b values of 0 and 1000 s/mm², voxel size: 0.9 × 0.9 × 5.0 mm³), and post-contrast T1W imaging (TR/TE, 600–1800/9–19 ms, voxel size: 0.5 × 0.5 × 1 mm³). A total volume of 0.1 mmol/kg of gadobenate dimeglumine was intravenously injected for post-contrast T1W imaging.

Sakai Y., Yang C., Kihira S., Tsankova N., Khan F., Hormigo A., Lai A., Cloughesy T, & Nael K. (2020). MRI Radiomic Features to Predict IDH1 Mutation Status in Gliomas: A Machine Learning Approach using Gradient Tree Boosting. International Journal of Molecular Sciences, 21(21), 8004.

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3T MRI Resting-State fMRI Protocol

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MRI was performed on two 3 Tesla whole‐body units, a GE Discovery 3T (location Amsterdam UMC, VU Medical Center Amsterdam) and a Philips Intera 3T (location University Medical Center Groningen), using a 32‐channel head‐coil. The MRI scanning protocol was part of a larger protocol which comprises structural and functional sequences in the following order: T1, DTI, resting‐state fMRI, and active‐state fMRI. Resting‐state data were acquired using a T2*‐weighted echo‐planar functional scan with 202 volumes, 38 ascending slices with slice thickness of 3 and 0.3 mm gap, matrix size of 64 × 64, TR = 2000 ms, TE = 35 ms, flip angle of 80 degrees and field of view = 211 mm. All scans were acquired with reversed phase‐encode blips which resulted in pairs of images with distortions presenting in opposite directions. From these pairs, the susceptibility‐induced off‐resonance field was estimated which was used to correct the susceptibility‐induced distortions in the data (Smith et al., 2004 (link)).

Meijer A., Königs M., Pouwels P.J., Smith J., Visscher C., Bosker R.J., Hartman E, & Oosterlaan J. (2022). Resting state networks mediate the association between both cardiovascular fitness and gross motor skills with neurocognitive functioning. Child Development, 93(4), e412-e426.

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Standardized Preoperative Brain Tumor MRI Protocol

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MR imaging was obtained using 7 MRI scanners (2 Skyra 3T and 2 Aera 1.5T from Siemens Healthineers, Erlangen Germany; 2 Signa 1.5T and one Discovery 3T from GE Healthcare) within our Radiology Department. Image acquisition was performed using a standardized preoperative brain tumor MRI protocol within our radiology department including: FLAIR (TR/TE/TI, 8000–12,000/98–130/2400–2700 ms, voxel size: 0.5 × 0.5 × 1 mm³), DWI (TR/TE: 4025–4600/65–82 ms, with b values of 0 and 1000 s/mm², voxel size: 0.9 × 0.9 × 5.0 mm³) and post-contrast T1W imaging (TR/TE, 600–1800/9–19 ms, voxel size: 0.5 × 0.5 × 1 mm³). A total volume of 0.1 mmol/kg of gadobenate dimeglumine was injected intravenously for post-contrast T1W imaging.

Kihira S., Tsankova N.M., Bauer A., Sakai Y., Mahmoudi K., Zubizarreta N., Houldsworth J., Khan F., Salamon N., Hormigo A, & Nael K. (2021). Multiparametric MRI texture analysis in prediction of glioma biomarker status: added value of MR diffusion. Neuro-oncology Advances, 3(1), vdab051.

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Multimodal Brain MRI Protocol

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All brain MRI scans were performed on either 1.5T or 3T MRI scanners (EXCITE HDXT 1.5T and DISCOVERY 3T General Electric, Milwaukee, WI, USA, and ESPREE 1.5T and SKYRA 3T Siemens AG, Munich, Germany). Due to the retrospective study design, there was variation in imaging protocols, sequences, and parameters obtained. Scans included a combination of T1, T2, T1 FLAIR, DWI, and SWI sequences. Twenty patients also had a 2D time-of-flight MR venogram available for review.

Benninger K.L., Maitre N.L., Ruess L, & Rusin J.A. (2019). MR Imaging Scoring System for White Matter Injury after Deep Medullary Vein Thrombosis and Infarction in Neonates. AJNR: American Journal of Neuroradiology, 40(2), 347-352.

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