Pvan data analysis software

Manufactured by Millar

Sourced in United States

PVAN data analysis software is a tool designed to analyze and interpret data generated from various experimental procedures. The software provides a platform for users to import, organize, and process data, enabling efficient data management and analysis.

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Lab products found in correlation

Spr 839, by Millar (5 mentions) Pressure volume system mpvs 400, by Millar (2 mentions) Mylab 30cv ultrasound, by Esaote (1 mentions) 10 mhz probe, by Esaote (1 mentions) Mylab 30cv, by Esaote (1 mentions) Mpvs 300, by Millar (1 mentions) Mpvs 400, by Millar (1 mentions)

6 protocols using pvan data analysis software

Cardiac Function Assessment in Mice

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After the mice were anesthetized using isoflurane (1.5%), echocardiography was performed using a MyLab 30CV ultrasound (Esaote SpA, Genoa, Italy) with a 10 MHz linear array ultrasound transducer. The left ventricle (LV) end-systolic diameter (LVESD), LV end-diastolic dimension (LVEDD), LV ejection fraction (EF), and LV fractional shortening (FS) were measured along the short axis of the left ventricle at the level of the papillary muscles.
Hemodynamic variables were analyzed using a Millar catheter transducer (SPR-839; Millar Instruments, Houston, TX). The maximal rate of pressure development (dp/dtmax) and the minimal rate of pressure decay (dp/dtmin) were processed using PVAN data analysis software (Millar, Inc. Houston, TX, USA). All surgeries and analyses were performed in a blinded manner.

Li L.L., Wei L., Zhang N., Wei W.Y., Hu C., Deng W, & Tang Q.Z. (2020). Levosimendan Protects against Doxorubicin-Induced Cardiotoxicity by Regulating the PTEN/Akt Pathway. BioMed Research International, 2020, 8593617.

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Cardiac Hemodynamics Measurement Protocol

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During the hemodynamic measurement, a microtip catheter transducer (SPR-839; Millar, Inc., Houston, TX, USA) was inserted into the right carotid artery and advanced gradually into the left ventricle under anesthesia with 1.5% isoflurane. The signals were continuously recorded using a Millar Pressure-Volume system (MPVS-400; Millar, Inc.) and analyzed using PVAN data analysis software (version 3.5; Millar, Inc.). The cardiac output, end-diastolic pressure, end-diastolic volume and Tau_w (left ventricular relaxation time constant) were measured by pressure volume (PV) loop.

Che Y., Wang Z.P., Yuan Y., Zhang N., Jin Y.G., Wan C.X, & Tang Q.Z. (2018). Role of autophagy in a model of obesity: A long-term high fat diet induces cardiac dysfunction. Molecular Medicine Reports, 18(3), 3251-3261.

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Echocardiography and Hemodynamic Assessment in Mice

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Mouse echocardiography was performed under sedation by 1.5% isoflurane inhalation. Short-axis parasternal views of the left ventricular systolic and diastolic parameters were obtained immediately at the mid-papillary level using a Vivid echocardiography apparatus with a 10-MHz probe (Esaote SpA, Genoa, Italy). M-mode measurements of the magnitude of the LV walls and chamber were achieved by two-dimensional guidance from the left ventricular short-axis view in a blinded manner as described previously [6 (link), 7 (link)]. LV end-diastolic diameter (LVEDd), LV end-systolic diameter (LVESd), and end-diastolic interventricular septal thickness (IVSd) were determined. The LV fractional shortening (FS) was computed using the following formula: FS (%) = (LVEDd-LVESd)/ LVEDd × 100.
For invasive hemodynamic analysis, mice were primarily anesthetized with 1.5% isoflurane inhalation. An incision was subsequently made in the right carotid artery and pressure–volume (PV) loop measurements were performed using a 1.4 Fr micromanometer conductance catheter (Millar, Houston, USA). Hemodynamic data were collected at steady state; PV loop parameters including the maximum rate of pressure development (dp/dt max) and minimum rate of pressure decay (dp/dt min) were calculated using the PVAN data analysis software (Millar, Houston, USA).

Wei W.Y., Zhao Q., Zhang W.Z., Wang M.J., Li Y., Wang S.Z, & Zhang N. (2020). Secreted frizzled-related protein 2 prevents pressure-overload-induced cardiac hypertrophy by targeting the Wnt/β-catenin pathway. Molecular and Cellular Biochemistry, 472(1-2), 241-251.

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Evaluation of Cardiac Function in Rats

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Left ventricular function was evaluated by echocardiography and catheter-based measurements of hemodynamic parameters. Briefly, after each rat was anaesthetized with chloral hydrate 10%, echocardiography was carried out using a Mylab 30CV (ESAOTE SpA; Florence, Italy) equipped with a 10-MHz linear array ultrasound transducer. Left ventricle (LV) dimensions were averaged from more than five cardiac cycles assessed in the parasternal short-axis view during systole or diastole. Interventricular septum thickness at diastole (IVSd) and left ventricular posterior wall thickness (LVPWd) were measured from the M-mode tracing with a sweep speed of 50 mm/s at the mid-papillary muscle level.
For hemodynamic measurements, after the induction of anesthesia with 1.5% isoflurane, a microtip catheter transducer (SPR-839, Millar Instruments; Houston, TX, USA) was inserted into the left ventricle of the rat via the right carotid artery. The signals were recorded using a Millar Pressure-Volume System (MPVS-400, Millar Instruments), and the end-diastolic pressure (EDP), end-systolic volume (ESV), time constant of isovolumic pressure decay (Tau_w), stroke volume (SV), ejection fraction (EF), and cardiac output (CO) were analyzed using PVAN data analysis software (Millar Instruments).

Che Y., Shen D.F., Wang Z.P., Jin Y.G., Wu Q.Q., Wang S.S, & Yuan Y. (2019). Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. BMC Cardiovascular Disorders, 19, 219.

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Cardiac Hemodynamics Monitoring Protocol

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After reperfusion, the pressure-volume tracheal catheter (SPR839, Millar Instruments Inc, USA) was inserted into the right common carotid artery, and then, the left ventricle was inserted using a pressure-volume conductance instrument (MPVS-300, Millar Instruments Inc, USA). Signals were recorded and calculated by a PVAN data analysis software (Millar Instruments Inc, USA). Haemodynamics parameters such as heart rate (HR), left ventricular systolic pressure (LVSP) and LVEF were measured.

Xu M., Li X, & Song L. (2020). Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway. Pharmaceutical Biology, 58(1), 655-663.

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Murine Cardiac Functional Analysis

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Pressure–volume loop analysis was performed in our laboratory according to published methods [18 (link)]. Briefly, mice were anesthetized with 1.5% isoflurane, and then, a microtip catheter transducer (SPR-839, Millar Instruments, Houston, TX) was inserted into the LV to record signals using a pressure–volume system (MPVS-400, Millar Instruments). Heart rate, LV end-diastolic pressure (LVEDP), LV end-systolic pressure (LVESP), LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), LV ejection fraction (LVEF), maximal rate of pressure development (dp/dt_max), minimal rate of pressure decay (dp/dt_min), cardiac output, and stroke work were analyzed using PVAN data analysis software (Millar Instruments).

Feng H., Mou S.Q., Li W.J., Zhang N., Zhou Z.Y., Ding W., Bian Z.Y, & Liao H.H. (2020). Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation. Oxidative Medicine and Cellular Longevity, 2020, 2647807.

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