Two of the 18 p.R47H carriers did not tolerate the 1.5 T MRI scan because of claustrophobia. Sixteen out of eighteen p.R47H carriers (ADNI1=9; Spanish=7), 74 cognitive impaired p.R47H noncarriers (ADNI1=27; Spanish= 47) and 74 cognitively intact p.R47H noncarriers (ADNI1=27; Spanish=47) underwent MRI scans. MRI studies of the Spanish subjects were all obtained on a 1.5-T Siemens Symphony scanner (Siemens, Erlaghen, Germany). High-resolution volumetric images were acquired in a T1-weighted MR sequence in-plane resolution voxel size 1x1x1. ADNI1 set: The T1-weighted images from ADNI were obtained using three different 1.5 T scanners. Nine AD TREM2 carriers, 12 AD TREM2 noncarriers and 18 cognitively intact p.R47H noncarriers’ images were acquired in a 1.5-T Siemens Symphony scanner. Ten of the remaining AD TREM2 noncarriers and the healthy control images were acquired in a 1.5 TGE Medical Systems equipment. Finally, 5 AD/MCI TREM2 noncarriers and 4 healthy control images were obtained with a Philips Medical Systems. Since the three image collections had different voxel sizes (X1=1.2 mm; Y1=1.2 mm; Z1=1.2 mm; X2=0.92 mm; Y2=0.92 mm; Z2=0.92 mm and X3=0.93 mm; Y3=0.93 mm; Z3=0.93 mm), all T1-weighted images were resized to the sequence in-plane resolution voxel size 1x1x1 using resize_img function with Matlab.
Symphony scanner
Manufactured by Siemens
Sourced in Germany
The Symphony scanner is a laboratory equipment product manufactured by Siemens. It is designed to provide advanced imaging capabilities for scientific and medical research applications. The core function of the Symphony scanner is to capture high-quality images and data through non-invasive scanning techniques.
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Lab products found in correlation
9 protocols using symphony scanner
1
MRI Scanning and Processing for TREM2 Alzheimer's Study
2
Multimodal MRI Neuroimaging Protocol
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The T1-weighted images obtained from five centers used five different 1.5 T scanners. Three FTD/SQSTM1 carriers underwent their MRI scan in 1.5 T GE Medical Systems scanner at two different centers, 5 FTD/SQSTM1 carriers in 1.5-T Siemens Symphony scanner at two different centers, and 2 in 1.5-T Philips Medical Systems at only one center. The MRI scans from Sporadic FTD and 20 HC/SQSTM1 subjects were acquired in 1.5-T Siemens Symphony scanners at two different centers. All T1-weighted images had a voxel size of 1 × 1 × 1 mm.
3
High-Resolution T1-Weighted Brain Imaging
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High-resolution T1-weighted anatomical images were acquired on a 1.5T Siemens Symphony scanner, using a standard 32-channel array head coil and an MPRAGE sequence: 176 sagittal slices (slice thickness = 1.17 mm); TR = 1,700 ms, TE = 3.93 ms, TI = 1,100 ms, flip angle = 15°; in plane matrix size 256 × 256, resampled to 512 × 512, FOV = 246 × 246 mm, in-plane resolution = 0.48 × 0.48 mm.
4
High-Resolution 3D Brain Imaging
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A coronal MP-RAGE sequence from a 1.5-T Siemens Symphony scanner was used in the present study. The acquisition parameters were: echo time = 2.38 ms, field of view = 250 × 203 mm, flip angle = 15 °, inversion time = 820 ms, matrix size = 512 × 416, acquisition pixel spacing = 1.0 × 1.0, reconstruction pixel spacing = 0.49 × 0.49 mm, repetition time = 1610 ms, slice thickness = 1 mm, bandwidth = 220, number of slices = 192, mean acquisition time = 1.97 min and transmit coil = body.
5
Whole-Brain fMRI Acquisition Protocol
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A total of 440 T2*-weighted whole brain volumes were acquired using a 1.5 T Symphony scanner (Siemens, Germany). Each volume consisted of 25 slices of 3 mm with an inter-slice gap of 1 mm. The repetition time was 80 ms per slice with a flip angle of 90°. We further acquired a high-resolution T1-weighted image with a voxel size of 1 × 1 × 1 mm and a repetition time of 2110 ms. The echo time was 3.93 ms with a flip angle of 15°. T1-weighted images were used for neuroanatomical localization and co-registration of the functional data.
6
Hippocampal Volume Measurement via 3D MRI
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Coronal, T1-weighted, 3D IR/GR (inversion recovery/gradient echo) MRI scans, obtained from a 1.5 T Siemens Symphony scanner, were used for the ICV segmentations. The coronal plane was aligned perpendicular to the longitudinal axis of hippocampus during the MRI examinations. All MRI examinations were performed at Sahlgrenska University Hospital, Mölndal radiology department. The acquisition parameters were: echo time = 2.38 ms, field of view = 250 x 203 mm, flip angle = 15°, inversion time = 820 ms, matrix size = 512 × 416, pixel spacing = 0.49 × 0.49 mm, repetition time = 1610 ms, slice thickness = 1 mm, bit depth = 12.
7
Multimodal Neuroimaging of ALS Patients
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Imaging parameters were tailored for acquisition during routine clinical imaging on a 1.5 T Siemens Symphony scanner (Erlangen, Germany) of patients being evaluated for ALS. Clinical T2- and PD-weighted images were obtained to assess CST hyperintensity using dual-echo fast spin echo sequences whose imaging parameters included: slice thickness = 4 mm, in-plane resolution = 0.9 × 0.9 mm; TR = 3900 ms, TEs = 26 ms (for PD) and 104 ms (for T2), total scan time = 3.5 min. DTI data were acquired during routine clinical scanning, which because of time constraints resulted in some compromises although still providing adequate quality data for quantitative analyses. Single shot-echo planar imaging (SS-EPI) sequence was used to acquire 12 diffusion-weighted (b = 1000 s/mm2) images and one b = 0 s/mm2 image. Imaging parameters included: resolution 1.9 × 1.9 × 4 mm3, repetition time TR = 6000 ms, echo time TE = 121 ms, EPI factor = 128, and scan time = 7.5 min. T1-weighted data were obtained using 3D magnetization-prepared rapid gradient echo (M-PRAGE) sequence. Imaging parameters included: 160 slices, voxel resolution of 1.0 × 1.0 × 1.0 mm, TR = 1970 ms, TE = 4.38 ms, and scan time = 6.5 min.
8
High-Resolution Structural and Task-fMRI Acquisition
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The same sequences were used in the three sessions, performed with a 1.5 T Siemens Symphony scanner (Erlangen, Germany), in order to collect the anatomical and functional MRI data. First, a high-resolution structural T1-weighted MPRAGE sequence was acquired (TR = 2200 ms; TE = 3 ms; flip angle 90 • , matrix = 256 × 256 × 160; voxel size = 1 × 1 × 1 mm). Finally, for task-fMRI (n-back), a gradient-echo T2*-weighted echo-planar MR sequence covering the entire brain was used (TR/TE = 2500/49 ms, matrix = 64 × 64 × 28, flip angle = 90 • , voxel size = 3.5 × 3.5 × 4.48; slice thickness = 4 mm; slice gap = 0.48 mm). A total of 260 volumes were recorded for n-back. All the scanner acquisitions were performed in parallel to the anterior commissure-posterior commissure plane (AC-PC), and they covered the entire brain. Participants were placed in a supine position in the MRI scanner, and their heads were immobilized with cushions to reduce involuntary motion. Furthermore, participants were asked to minimize head movement, even while giving the answers.
9
Functional MRI Data Acquisition Protocol
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Functional MRI data were collected on a 1.5T Siemens Symphony scanner (Erlangen, Germany). The same sequences were used in the three sessions. Participants were placed in a supine position in the MRI scanner, and their heads were immobilized with cushions to reduce motion artifacts. For task-fMRI, a gradient-echo T2*-weighted echo-planar MR sequence covering the entire brain was used (TR/TE=2500/49ms, matrix=64x64x28, flip angle = 90°, voxel size=3.5x3.5x4.48; slice thickness = 4 mm; slice gap = 0.48 mm). A total of 270 volumes were recorded. The slices were made parallel to the anteriorposterior commissure plane covering the entire brain. Before the functional magnetic resonance sequences, a high-resolution structural T1-weighted MPRAGE sequence was acquired (TR = 2200 ms; TE = 3 ms; flip angle 90º, matrix = 256 x 256 x 160; voxel size = 1 x 1 x 1 mm).
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