All rats that underwent OVX or sham surgery were anesthetized with ketamine HCl (80–100 mg/kg, i.m.) and xylazine (8 mg/kg, i.m.). A dorsolateral incision through the skin and peritoneum was made directly above both ovaries. A ligature was then applied to the tip of each uterine horn, and each ovary was removed. For sham surgeries, the incision was made through the skin and peritoneum; however, the ovaries were left intact. The abdominal wall muscle was sutured using coated VICRYL suture (Ethicon), and staples were used to adhere the skin incision above the muscle suturing. Rats were given cefazolin (100 mg/kg, s.c.) and meloxicam (1 mg/kg, s.c.) on the day of surgery and once daily for 3 d during the postsurgical recovery period.
Coated vicryl suture
Manufactured by Johnson & Johnson
Coated VICRYL Suture is a sterile, absorbable surgical suture made of polyglactin 910, a copolymer of glycolide and lactide. The suture is coated to enhance handling characteristics and tissue drag.
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Lab products found in correlation
4 protocols using coated vicryl suture
1
Ovariectomy and Sham Surgery in Rats
2
Ovariectomy Surgery Protocol for Rats
3
Cadaveric Evaluation of Knee Suture Techniques
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A human cadaveric study was performed using 20 fresh-frozen specimens from 10 donors (10 right legs and 10 left legs). The cadaveric specimens were obtained from Science Care (Phoenix, AZ), and all specimens were fully intact lower extremities from donors with no history of inflammatory arthritis, septic arthritis, cancer, knee trauma, radiation therapy, or prior lower extremity surgery. Each cadaver specimen was stored at -20°C and allowed to thaw at room temperature for a minimum of 48 hours before the start of the study. All procedures and arthrotomy closures were performed by an adult reconstruction fellowship-trained orthopedic surgeon. Arthrotomy closure was performed with either the test suture of STRATAFIX Symmetric PDS Plus (Size 1, CT-1 needle; Ethicon Inc, Somerville, NJ) or the control suture of Coated VICRYL Suture (Size 1, CT-1 needle; Ethicon Inc, Somerville, NJ). Using an “out of the hat” randomization, one knee was selected to be closed using the test suture in a continuous pattern, and the contralateral knee from the same donor was closed using the control suture in an inverted figure-8 interrupted pattern.
4
Parabiosis Surgery Protocol for Mouse Studies
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Parabiosis surgery followed previously described procedures45 (link). Mirror-image skin incisions at the left and right flanks were made through the skin, and shorter incisions were made through the peritoneum. The peritoneal openings of the adjacent parabionts were sutured together with chromic gut suture (MYCO Medical, GC635-BRC). Apposing elbow and knee joints from each parabiont were sutured together (Coated VICRYL Suture, Ethicon, J386) and the skin of each mouse was stapled (9-mm Autoclip, Clay Adams, 427631) to the skin of the adjacent parabiont. Each mouse was injected subcutaneously with Carpofen, Enrofloxacin, and Buprenex as directed for pain and monitored during recovery. For overall health and maintenance behavior, several recovery characteristics were analyzed at various times after surgery, including pair weights and grooming behavior.
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