6 gingerol

Manufactured by ChromaDex

Sourced in United States

6-gingerol is a naturally occurring phytochemical compound found in ginger root. It is a white crystalline solid that can be used as a reference standard or analytical tool in laboratory settings. 6-gingerol serves as a marker compound for the identification and quantification of ginger-derived materials through analytical techniques such as high-performance liquid chromatography (HPLC) or gas chromatography-mass spectrometry (GC-MS).

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Lab products found in correlation

3 protocols using 6 gingerol

Quantification of Bioactive Spice Compounds

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All organic solvents were High‐performance liquid chromatography (HPLC) grade (Thermo Fisher Scientific, Fairlawn, N.J., U.S.A.). Deionized water was purified by the Milli‐Q system (Millipore, Bedford, Mass., U.S.A.). Reference standards apigenin, capsaicin, dihydrocapsaicin, cinnamic acid, cinnamaldehyde, p‐coumaric acid, bis demethoxy curcumin, demethoxy curcumin, curcumin, luteolin, luteolin‐3‐glucuronide, piperine, rosmarinic acid, and vanillin were purchased from Sigma‐Aldrich (St. Louis, Mo., U.S.A.). Ferulic acid was purchased from USP (Rockville, Md., U.S.A.) and 6‐gingerol from Chromadex (Irvine, Calif., U.S.A.). They were used for the identification and quantification of spice chemicals.

Lu Q., Summanen P.H., Lee R., Huang J., Henning S.M., Heber D., Finegold S.M, & Li Z. (2017). Prebiotic Potential and Chemical Composition of Seven Culinary Spice Extracts. Journal of Food Science, 82(8), 1807-1813.

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Ginger Phytochemicals and Cell Viability

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LPS from Escherichia coli O55:B5, adenosine 5’-triphosphate (ATP), phorbol 12-myristate 13-acetate (PMA), dimethyl sulfoxide (DMSO), and 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) for cell culture experiment were acquired from Sigma-Aldrich (St. Louis, MO, USA). The ginger phytochemicals, including 6-gingerol (C₁₇H₂₆O₄), 8-gingerol (C₁₉H₃₀O₄), 10-gingerol (C₂₁H₃₄O₄), 6-shogaol (C₁₇H₂₄O₃), 8-shogaol (C₁₉H₂₈O₃), and 10-shogaol (C₂₁H₃₂O₃) with a purity of >99% were procured from ChromaDex (Irvine, CA, USA). Cell culture medium and reagents were obtained from Thermo Fisher Scientific (Grand Island, NE, USA). All other chemicals used were analytical grade.

Ho S.C, & Chang Y.H. (2018). Comparison of Inhibitory Capacities of 6-, 8- and 10-Gingerols/Shogaols on the Canonical NLRP3 Inflammasome-Mediated IL-1β Secretion. Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 23(2), 466.

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Antioxidant Compounds from Ginger

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6-Shogaol, 6-gingerol, 8-gingerol, and 10-gingerol were purchased from Chromadex company (Irvine, CA, USA). Dulbecco's modification of Eagle medium (DMEM), fetal bovine serum (FBS), and Antibiotic-Antimycotic (AA) were purchased from Gibco-BRL (Carlsbad, CA, USA), and 2′,7′-dichlorodihydrofluorescein diacetate (DCF-DA) was obtained from Sigma Aldirch (St. Louis, MO, USA). Nucleospin was purchased from MACH-EREY-NAGEL. (MACHEREY-NAGEL INC, PA, USA), iQ TM SYBR ® Green Supermix, and iScript ™ Reverse Transcription Supermix for RT-qPCR were purchased from Bio-Rad (Hercules, CA, USA). HO-1 antibody was purchased from Enzo Life Science (Farmingdale, USA). NRF-2 antibody was purchased from Abcam (Cambridge, UK).

Hur J., Lee Y., Lee C.J., Park H., & Choi S.Y. (2020). 6-shogaol suppresses oxidative damage in L6 muscle cells. Applied Biological Chemistry, 63(1).

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