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Tetrodotoxin citrate ttx

Manufactured by Abcam
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Tetrodotoxin citrate (TTX) is a sodium channel blocker that inhibits the entry of sodium ions into excitable cells, including neurons and muscle cells. It is an active ingredient commonly used in research applications to study the role of sodium channels in biological processes.

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Lab products found in correlation

Picrotoxin, by Merck Group (2 mentions) Sonic hedgehog, by R&D Systems (2 mentions) Chloryl hydrate, by Merck Group (2 mentions) K methylsulfate, by Thermo Fisher Scientific (2 mentions) Guanosine 5 triphosphate sodium salt hydrate, by Merck Group (2 mentions) Neurobiotin tracer, by Vector Laboratories (2 mentions) N2 and b27 supplements, by Thermo Fisher Scientific (2 mentions) Insulin like growth factor 1, by R&D Systems (2 mentions) Cell culture media, by Thermo Fisher Scientific (2 mentions) Leukemia inhibitory factor, by Thermo Fisher Scientific (2 mentions) Adenosine 5 triphosphate magnesium salt, by Merck Group (2 mentions) Cyclosporin a, by Thermo Fisher Scientific (2 mentions) Mk 801, by Merck Group (2 mentions) Ethylene glycol tetraacetic acid (egta), by Merck Group (2 mentions) Fibroblast growth factor 2 (fgf2), by R&D Systems (2 mentions) Pentobarbital, by Merck Group (2 mentions) Kynurenic acid, by Merck Group (2 mentions) Lidocaine hydrochloride, by Merck Group (1 mentions) N heptanol, by Merck Group (1 mentions) 6 cyano 7 nitroquinoxaline 2 3 dione cnqx, by Bio-Techne (1 mentions)

4 protocols using tetrodotoxin citrate ttx

1

Neuronal Culture Reagent Procurement

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DNQX, picrotoxin, MK-801, kynurenic acid, guanosine 5′ triphosphate sodium salt hydrate (GTP), adenosine 5′ triphosphate magnesium salt (ATP), EGTA, Pentobarbital, and chloryl hydrate were purchased from Sigma-Aldrich. K-methylsulfate was purchased from Acros Organics. Tetrodotoxin citrate (TTX) was purchased from AbCam. Neurobiotin tracer was purchased from Vector Laboratories. Cell culture media and Leukemia inhibitory factor were purchased from Life Technologies. LDN-193189, Y27632, and XAV939 were purchased from Stemgent. Fibroblast growth factor-2, Insulin-like growth factor-1, and sonic hedgehog were purchased from R&D Systems. N2 and B27 supplements were purchased from Gibco. Cyclosporin A was purchased from Fisher Scientific.
Donegan J.J., Tyson J.A., Branch S.Y., Beckstead M.J., Anderson S.A, & Lodge D.J. (2016). Stem cell derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model. Molecular psychiatry, 22(10), 1492-1501.
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2

Tetrodotoxin and Lidocaine Preparation

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Tetrodotoxin citrate (TTX) was obtained from Abcam (Cambridge, MA, USA), and lidocaine hydrochloride and n-heptanol were obtained from Sigma Chemical Co. (St. Louis, MO, USA). TTX and lidocaine were dissolved in 0.9% saline. The n-heptanol was used undiluted.
Green P.G., Alvarez P, & Levine J.D. (2015). Topical tetrodotoxin attenuates photophobia induced by corneal injury in the rat. The journal of pain : official journal of the American Pain Society, 16(9), 881-886.
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3

Neuronal Culture Reagent Procurement

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DNQX, picrotoxin, MK-801, kynurenic acid, guanosine 5′ triphosphate sodium salt hydrate (GTP), adenosine 5′ triphosphate magnesium salt (ATP), EGTA, Pentobarbital, and chloryl hydrate were purchased from Sigma-Aldrich. K-methylsulfate was purchased from Acros Organics. Tetrodotoxin citrate (TTX) was purchased from AbCam. Neurobiotin tracer was purchased from Vector Laboratories. Cell culture media and Leukemia inhibitory factor were purchased from Life Technologies. LDN-193189, Y27632, and XAV939 were purchased from Stemgent. Fibroblast growth factor-2, Insulin-like growth factor-1, and sonic hedgehog were purchased from R&D Systems. N2 and B27 supplements were purchased from Gibco. Cyclosporin A was purchased from Fisher Scientific.
Donegan J.J., Tyson J.A., Branch S.Y., Beckstead M.J., Anderson S.A, & Lodge D.J. (2016). Stem cell derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model. Molecular psychiatry, 22(10), 1492-1501.
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4

Neurotransmitter Receptor Modulation Assay

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Picrotoxin (PTX), atropine sulfate (atropine), acetylcholine chloride, and 4-aminopyridine (4AP) were obtained from Sigma. 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-(-)−2-amino-5-phosphonopentanoic acid (D-AP5) were obtained from Tocris. QX314 chloride (QX314) was from EMD-Millipore. Tetrodotoxin citrate (TTX) was obtained from Abcam. Nicotine hydrogen tartrate salt was obtained from Glentham Life Sciences. Injectable heparin sodium was from Patterson Veterinary Supply.
Jin X.T., Tucker B.R, & Drenan R.M. (2020). Nicotine Self-Administration Induces Plastic Changes to Nicotinic Receptors in Medial Habenula. eNeuro, 7(4), ENEURO.0197-20.2020.
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